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ENZYME entry: EC 4.2.3.132

Accepted Name
Neoabietadiene synthase.
Reaction catalysed
(+)-copalyl diphosphate <=> neoabietadiene + diphosphate
Comment(s)
  • Isolated from Abies grandis (grand fir).
  • This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene; see also EC 4.2.3.18 and EC 4.2.3.32.
  • An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while EC 5.5.1.12 activity (a class II activity) is in the beta and gamma domains.
  • In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene.
Cross-references
BRENDA4.2.3.132
EC2PDB4.2.3.132
ExplorEnz4.2.3.132
PRIAM enzyme-specific profiles4.2.3.132
KEGG Ligand Database for Enzyme Nomenclature4.2.3.132
IUBMB Enzyme Nomenclature4.2.3.132
IntEnz4.2.3.132
MEDLINEFind literature relating to 4.2.3.132
MetaCyc4.2.3.132
UniProtKB/Swiss-Prot
H8ZM70, LAS_ABIBA;  M4HXU6, TPSD1_PINBN;  M4HY05, TPSD1_PINCO;  
Q50EK2, TPSD1_PINTA;  M4HYC6, TPSD2_PINCO;  Q38710, TPSDV_ABIGR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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