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ENZYME

ENZYME entry: EC 4.2.3.132

Accepted Name
neoabietadiene synthase
Reaction catalysed
(+)-copalyl diphosphate <=> diphosphate + neoabietadiene
Comment(s)
  • Isolated from Abies grandis (grand fir).
  • This class I enzyme forms about equal proportions of abietadiene, levopimaradiene and neoabietadiene; see also EC 4.2.3.18 and EC 4.2.3.32.
  • An X-ray study of this multifunctional enzyme showed that the class I activity is in the alpha domain, while EC 5.5.1.12 activity (a class II activity) is in the beta and gamma domains.
  • In Pinus taeda (loblolly pine) the major product is levopimaradiene, with less abietadiene and neoabietadiene.
Cross-references
BRENDA4.2.3.132
EC2PDB4.2.3.132
ExplorEnz4.2.3.132
PRIAM enzyme-specific profiles4.2.3.132
KEGG Ligand Database for Enzyme Nomenclature4.2.3.132
IUBMB Enzyme Nomenclature4.2.3.132
IntEnz4.2.3.132
MEDLINEFind literature relating to 4.2.3.132
MetaCyc4.2.3.132
Rhea expert-curated reactions4.2.3.132
UniProtKB/Swiss-Prot
H8ZM70, LAS_ABIBAM4HXU6, TPSD1_PINBNM4HY05, TPSD1_PINCO
Q50EK2, TPSD1_PINTAM4HYC6, TPSD2_PINCOQ38710, TPSDV_ABIGR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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