ID   4.2.3.152
DE   2-epi-5-epi-valiolone synthase.
AN   C7-cyclitol synthase.
CA   D-sedoheptulose 7-phosphate = 2-epi-5-epi-valiolone + phosphate.
CC   -!- The enzyme is highly specific for alpha-D-sedoheptulopyranose
CC       7-phosphate.
CC   -!- It requires a divalent metal ion (Zn(2+) or Co(2+)) and an NAD(+)
CC       cofactor, which is transiently reduced during the reaction.
CC   -!- The enzyme is involved in the biosynthesis of C7N-aminocyclitol
CC       natural products, such as the valienamine moiety of the antidiabetic
CC       drug acarbose and the crop protectant validamycin A. cf. EC 4.2.3.154
CC       and EC 4.2.3.155.
DR   Q9ZAE9, ACBC_ACTS5 ;  A1YPR2, CETA_ACTSX ;  E3FKM2, EEVS_STIAD ;
DR   B0B0T7, EEVS_STRGA ;  A8D7K2, SALQ_STRA4 ;  H2K887, VALA_STRHJ ;
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