ENZYME entry: EC 4.2.3.17

Accepted Name
Taxadiene synthase.
Alternative Name(s)
Taxa-4(5),11(12)-diene synthase.
Taxadiene cyclase.
Reaction catalysed
Geranylgeranyl diphosphate <=> taxa-4,11-diene + diphosphate
Comment(s)
  • This is the committed step in the biosynthesis of the diterpenoid antineoplastic drug Taxol (paclitaxel).
  • The cyclization involves a 1,5-hydride shift.
Cross-references
BRENDA4.2.3.17
EC2PDB4.2.3.17
ExplorEnz4.2.3.17
PRIAM enzyme-specific profiles4.2.3.17
KEGG Ligand Database for Enzyme Nomenclature4.2.3.17
IUBMB Enzyme Nomenclature4.2.3.17
IntEnz4.2.3.17
MEDLINEFind literature relating to 4.2.3.17
MetaCyc4.2.3.17
UniProtKB/Swiss-Prot
Q93YA3, TASY_TAXBA;  Q41594, TASY_TAXBR;  Q9FT37, TASY_TAXWC;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
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