ENZYME entry: EC 4.2.3.17
| Accepted Name |
|---|
| Taxadiene synthase.
|
| Alternative Name(s) |
|---|
| Taxa-4(5),11(12)-diene synthase. |
| Taxadiene cyclase. |
| Reaction catalysed |
|---|
| Geranylgeranyl diphosphate <=> taxa-4,11-diene + diphosphate |
| Comment(s) |
|---|
- This is the committed step in the biosynthesis of the diterpenoid
antineoplastic drug Taxol (paclitaxel).
- The cyclization involves a 1,5-hydride shift.
|
| Cross-references |
|---|
| BRENDA | 4.2.3.17 |
| EC2PDB | 4.2.3.17 |
| ExplorEnz | 4.2.3.17 |
| PRIAM enzyme-specific profiles | 4.2.3.17 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.17 |
| IUBMB Enzyme Nomenclature | 4.2.3.17 |
| IntEnz | 4.2.3.17 |
| MEDLINE | Find literature relating to 4.2.3.17 |
| MetaCyc | 4.2.3.17 |
| UniProtKB/Swiss-Prot |
|
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