ENZYME entry: EC 4.2.3.22
| Accepted Name |
|---|
| Germacradienol synthase.
|
| Alternative Name(s) |
|---|
| Germacradienol/germacrene-D synthase. |
| Reaction catalysed |
|---|
| (2E,6E)-farnesyl diphosphate + H(2)O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate |
| Cofactor(s) |
|---|
| Magnesium.
|
| Comment(s) |
|---|
- H-1si of farnesyl diphosphate is lost in the formation of
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol.
- Formation of (-)-germacrene D involves a stereospecific 1,3-hydride
shift of H-1si of farnesyl diphosphate.
- Both products are formed from a common intermediate.
- The enzyme mediates a key step in the biosynthesis of geosmin (see
EC 4.1.99.16), a widely occurring metabolite of many streptomycetes,
bacteria and fungi.
- Also catalyzes the reaction of EC 4.2.3.75.
|
| Cross-references |
|---|
| BRENDA | 4.2.3.22 |
| EC2PDB | 4.2.3.22 |
| ExplorEnz | 4.2.3.22 |
| PRIAM enzyme-specific profiles | 4.2.3.22 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.2.3.22 |
| IUBMB Enzyme Nomenclature | 4.2.3.22 |
| IntEnz | 4.2.3.22 |
| MEDLINE | Find literature relating to 4.2.3.22 |
| MetaCyc | 4.2.3.22 |
| UniProtKB/Swiss-Prot |
|
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