ENZYME entry: EC 4.2.3.22

Accepted Name
Germacradienol synthase.
Alternative Name(s)
Germacradienol/germacrene-D synthase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + H(2)O <=> (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
Cofactor(s)
Magnesium.
Comment(s)
  • H-1si of farnesyl diphosphate is lost in the formation of (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol.
  • Formation of (-)-germacrene D involves a stereospecific 1,3-hydride shift of H-1si of farnesyl diphosphate.
  • Both products are formed from a common intermediate.
  • The enzyme mediates a key step in the biosynthesis of geosmin (see EC 4.1.99.16), a widely occurring metabolite of many streptomycetes, bacteria and fungi.
  • Also catalyzes the reaction of EC 4.2.3.75.
Cross-references
BRENDA4.2.3.22
EC2PDB4.2.3.22
ExplorEnz4.2.3.22
PRIAM enzyme-specific profiles4.2.3.22
KEGG Ligand Database for Enzyme Nomenclature4.2.3.22
IUBMB Enzyme Nomenclature4.2.3.22
IntEnz4.2.3.22
MEDLINEFind literature relating to 4.2.3.22
MetaCyc4.2.3.22
UniProtKB/Swiss-Prot
Q9X839, CYC2_STRCO;  Q6Q3H3, TPSGD_VITVI;  

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