ENZYME entry: EC 4.2.3.98

Accepted Name
(+)-T-muurolol synthase.
Reaction catalysed
(2E,6E)-farnesyl diphosphate + H(2)O <=> (+)-T-muurolol + diphosphate
Comment(s)
  • The cyclization mechanism involves an intermediate nerolidyl diphosphate leading to a helminthogermacradienyl cation.
  • After a 1,3-hydride shift of the original 1-pro-(S) hydrogen of farnesyl diphosphate, cyclization and deprotonation result in (+)-T- muurolol.
Cross-references
BRENDA4.2.3.98
EC2PDB4.2.3.98
ExplorEnz4.2.3.98
PRIAM enzyme-specific profiles4.2.3.98
KEGG Ligand Database for Enzyme Nomenclature4.2.3.98
IUBMB Enzyme Nomenclature4.2.3.98
IntEnz4.2.3.98
MEDLINEFind literature relating to 4.2.3.98
MetaCyc4.2.3.98
UniProtKB/Swiss-Prot
B5GW45, TMUUS_STRC2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
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