ENZYME entry: EC 4.2.99.20

Accepted Name
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase.
Alternative Name(s)
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid synthase.
6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate synthase.
SHCHC synthase.
Reaction catalysed
5-enolpyruvoyl-6-hydroxy-2-succinylcyclohex-3-ene-1-carboxylate <=> (1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate + pyruvate
Comment(s)
  • Involved in the biosynthesis of vitamin K2 (menaquinone).
  • In most anaerobes and all Gram-positive aerobes, menaquinone is the sole electron transporter in the respiratory chain and is essential for their survival.
  • It had previously been thought that the reactions carried out by this enzyme and EC 2.2.1.9 were carried out by a single enzyme but this has since been disproved.
  • Formerly EC 2.5.1.64 and EC 4.2.99.n1.
Cross-references
BRENDA4.2.99.20
EC2PDB4.2.99.20
ExplorEnz4.2.99.20
PRIAM enzyme-specific profiles4.2.99.20
KEGG Ligand Database for Enzyme Nomenclature4.2.99.20
IUBMB Enzyme Nomenclature4.2.99.20
IntEnz4.2.99.20
MEDLINEFind literature relating to 4.2.99.20
MetaCyc4.2.99.20
UniProtKB/Swiss-Prot
P23974, MENH_BACSU;  A8ADX0, MENH_CITK8;  A7MHU5, MENH_CROS8;  
A7ZP82, MENH_ECO24;  B7UFS6, MENH_ECO27;  B7MG31, MENH_ECO45;  
B7LAS9, MENH_ECO55;  Q8XDX9, MENH_ECO57;  B5YXQ7, MENH_ECO5E;  
B7NNU3, MENH_ECO7I;  B7MXU6, MENH_ECO81;  B7M5U6, MENH_ECO8A;  
C4ZUA6, MENH_ECOBW;  B1X8X7, MENH_ECODH;  A8A2D1, MENH_ECOHS;  
A1ADB5, MENH_ECOK1;  Q0TFH8, MENH_ECOL5;  Q8FFL2, MENH_ECOL6;  
B1IXS3, MENH_ECOLC;  P37355, MENH_ECOLI;  B7N5M9, MENH_ECOLU;  
B6I7K7, MENH_ECOSE;  B1LLL8, MENH_ECOSM;  Q1R9F0, MENH_ECOUT;  
A4WCP8, MENH_ENT38;  B7LM67, MENH_ESCF3;  P44611, MENH_HAEIN;  
B5XNX1, MENH_KLEP3;  A6TBV7, MENH_KLEP7;  Q6D7W3, MENH_PECAS;  
Q7N2K4, MENH_PHOLL;  B5EZI7, MENH_SALA4;  A9MJB7, MENH_SALAR;  
Q57M48, MENH_SALCH;  B5FPE7, MENH_SALDC;  B5R2Y9, MENH_SALEP;  
B5RCD3, MENH_SALG2;  B4TBH5, MENH_SALHS;  B4SYY0, MENH_SALNS;  
Q5PN75, MENH_SALPA;  A9N5A3, MENH_SALPB;  C0Q060, MENH_SALPC;  
B5BCN7, MENH_SALPK;  B4TPJ1, MENH_SALSV;  Q8Z534, MENH_SALTI;  
Q8ZNE9, MENH_SALTY;  A8GGZ0, MENH_SERP5;  B2TW49, MENH_SHIB3;  
Q31YJ4, MENH_SHIBS;  Q32DS5, MENH_SHIDS;  Q0T2M0, MENH_SHIF8;  
Q83QT4, MENH_SHIFL;  Q3YZU3, MENH_SHISS;  A1JKU0, MENH_YERE8;  
A7FGT3, MENH_YERP3;  Q1C6D8, MENH_YERPA;  B2K7Z2, MENH_YERPB;  
Q7CJ75, MENH_YERPE;  A9R6I9, MENH_YERPG;  Q1CHT0, MENH_YERPN;  
A4TM07, MENH_YERPP;  Q669C8, MENH_YERPS;  B1JH89, MENH_YERPY;  
Q15KI9, PHYLO_ARATH;  

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