ENZYME entry: EC 4.3.1.17

Accepted Name
L-serine ammonia-lyase.
Alternative Name(s)
L-hydroxyaminoacid dehydratase.
L-serine deaminase.
L-serine dehydratase.
L-serine hydro-lyase (deaminating).
Serine deaminase.
Reaction catalysed
L-serine <=> pyruvate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • This reaction is also carried out by EC 4.3.1.19 from a number of sources.
  • The reaction catalyzed probably involves initial elimination of water (hence the enzyme's original classification as EC 4.2.1.13), followed by isomerization and hydrolysis of the product with C-N bond breakage.
  • Formerly EC 4.2.1.13.
Cross-references
PROSITEPDOC00149
BRENDA4.3.1.17
EC2PDB4.3.1.17
ExplorEnz4.3.1.17
PRIAM enzyme-specific profiles4.3.1.17
KEGG Ligand Database for Enzyme Nomenclature4.3.1.17
IUBMB Enzyme Nomenclature4.3.1.17
IntEnz4.3.1.17
MEDLINEFind literature relating to 4.3.1.17
MetaCyc4.3.1.17
UniProtKB/Swiss-Prot
P0CF21, SDH1_YEAST;  P0CF23, SDH1_YEASX;  O34607, SDHA_BACSU;  
P80212, SDHA_CLOPR;  Q48838, SDHA_LACSK;  P33073, SDHA_PEPAS;  
O34635, SDHB_BACSU;  P80213, SDHB_CLOPR;  P33074, SDHB_PEPAS;  
Q0VCW4, SDHL_BOVIN;  Q86B06, SDHL_DICDI;  P16095, SDHL_ECOLI;  
P71349, SDHL_HAEIN;  Q9ZMU7, SDHL_HELPJ;  P56072, SDHL_HELPY;  
P20132, SDHL_HUMAN;  Q8VBT2, SDHL_MOUSE;  P66774, SDHL_MYCBO;  
P66773, SDHL_MYCTU;  P09367, SDHL_RAT;  O86564, SDHL_STRCO;  
B3LU13, SDHL_YEAS1;  B5VKE8, SDHL_YEAS6;  A6ZVB1, SDHL_YEAS7;  
C8ZAU6, SDHL_YEAS8;  P30744, SDHM_ECOLI;  Q96GA7, SDSL_HUMAN;  
Q8R238, SDSL_MOUSE;  A0JNI4, SRR_BOVIN;  Q54HH2, SRR_DICDI;  
Q9GZT4, SRR_HUMAN;  Q9QZX7, SRR_MOUSE;  Q76EQ0, SRR_RAT;  
O59791, SRR_SCHPO;  P25379, STDH_YEAST;  P42630, TDCG_ECOLI;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-