ENZYME entry: EC 4.3.1.18

Accepted Name
D-serine ammonia-lyase.
Alternative Name(s)
D-hydroxy amino acid dehydratase.
D-serine deaminase.
D-serine dehydrase.
D-serine dehydratase.
D-serine dehydratase (deaminating).
D-serine hydro-lyase (deaminating).
D-serine hydrolase.
Reaction catalysed
D-serine <=> pyruvate + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme cleaves a carbon-oxygen bond, releasing a water molecule (hence the enzyme's original classification as EC 4.2.1.14) and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Also acts, slowly, on D-threonine.
  • Formerly EC 4.2.1.14.
Cross-references
BRENDA4.3.1.18
EC2PDB4.3.1.18
ExplorEnz4.3.1.18
PRIAM enzyme-specific profiles4.3.1.18
KEGG Ligand Database for Enzyme Nomenclature4.3.1.18
IUBMB Enzyme Nomenclature4.3.1.18
IntEnz4.3.1.18
MEDLINEFind literature relating to 4.3.1.18
MetaCyc4.3.1.18
UniProtKB/Swiss-Prot
Q9US35, DSD1_SCHPO;  P53095, DSD1_YEAST;  Q0TF95, SDHD1_ECOL5;  
Q1R901, SDHD1_ECOUT;  Q0T953, SDHD2_ECOL5;  Q1R2Q6, SDHD2_ECOUT;  
A1TPW5, SDHD_ACIAC;  Q6FDC1, SDHD_ACIAD;  B7I8P7, SDHD_ACIB5;  
B2HVC6, SDHD_ACIBC;  A3M3B1, SDHD_ACIBT;  B9MIR7, SDHD_ACIET;  
A1W838, SDHD_ACISJ;  A0KI76, SDHD_AERHH;  A4SPX2, SDHD_AERS4;  
C3L7G5, SDHD_BACAC;  A0RCF8, SDHD_BACAH;  Q81S85, SDHD_BACAN;  
Q73AC5, SDHD_BACC1;  B7IR88, SDHD_BACC2;  C1EPF1, SDHD_BACC3;  
B7HID8, SDHD_BACC4;  B7HMG6, SDHD_BACC7;  Q81F73, SDHD_BACCR;  
Q63D23, SDHD_BACCZ;  Q9KC12, SDHD_BACHD;  Q6HKG3, SDHD_BACHK;  
Q5WGL6, SDHD_BACSK;  P54555, SDHD_BACSU;  A9VPH9, SDHD_BACWK;  
A3P975, SDHD_BURP0;  Q3JJ76, SDHD_BURP1;  A3NNQ0, SDHD_BURP6;  
Q63IF8, SDHD_BURPS;  Q396Y3, SDHD_BURS3;  Q2T8Q2, SDHD_BURTA;  
Q3AFZ5, SDHD_CARHZ;  Q7NUP9, SDHD_CHRVO;  A8ACI7, SDHD_CITK8;  
Q47V69, SDHD_COLP3;  Q46X58, SDHD_CUPPJ;  Q24WR0, SDHD_DESHY;  
A7ZPH2, SDHD_ECO24;  B7MH26, SDHD_ECO45;  B7LBR9, SDHD_ECO55;  
Q8XCK5, SDHD_ECO57;  B5YYW7, SDHD_ECO5E;  B7MY25, SDHD_ECO81;  
B7M6N5, SDHD_ECO8A;  C4ZVQ3, SDHD_ECOBW;  B1X9N9, SDHD_ECODH;  
A8A2M0, SDHD_ECOHS;  A1ADP3, SDHD_ECOK1;  Q8FFF4, SDHD_ECOL6;  
B1IX96, SDHD_ECOLC;  P00926, SDHD_ECOLI;  B7N5W6, SDHD_ECOLU;  
B6I6R7, SDHD_ECOSE;  B7LK20, SDHD_ESCF3;  Q8RFX6, SDHD_FUSNN;  
Q75TC9, SDHD_GEOKA;  Q75TH5, SDHD_GEOSE;  Q2SHX7, SDHD_HAHCH;  
Q0I5V1, SDHD_HISS1;  B0UWV3, SDHD_HISS2;  B2GBP8, SDHD_LACF3;  
Q88TY1, SDHD_LACPL;  Q04G28, SDHD_OENOB;  Q03DF6, SDHD_PEDPA;  
Q7N5H9, SDHD_PHOLL;  Q6LHF5, SDHD_PHOPR;  A1VWK8, SDHD_POLNA;  
A6V271, SDHD_PSEA7;  B7V2Y0, SDHD_PSEA8;  Q02QJ1, SDHD_PSEAB;  
Q9HYN9, SDHD_PSEAE;  A4XXF3, SDHD_PSEMY;  A5W4Y8, SDHD_PSEP1;  
B0KGK3, SDHD_PSEPG;  B3PYT5, SDHD_RHIE6;  B5ZNC1, SDHD_RHILW;  
B5EY75, SDHD_SALA4;  A9MKH2, SDHD_SALAR;  Q57I32, SDHD_SALCH;  
B5FMC1, SDHD_SALDC;  B5QU31, SDHD_SALEP;  B5RG23, SDHD_SALG2;  
B4TA53, SDHD_SALHS;  B4SY68, SDHD_SALNS;  Q5PKR3, SDHD_SALPA;  
A9MWI4, SDHD_SALPB;  C0Q241, SDHD_SALPC;  B5BII6, SDHD_SALPK;  
B4TMW9, SDHD_SALSV;  Q8Z2L4, SDHD_SALTI;  Q8ZL08, SDHD_SALTY;  
A8GES6, SDHD_SERP5;  Q31YA5, SDHD_SHIBS;  Q32DH8, SDHD_SHIDS;  
Q0T2D1, SDHD_SHIF8;  Q83MK8, SDHD_SHIFL;  Q3YZG4, SDHD_SHISS;  
A6UB95, SDHD_SINMW;  Q4A041, SDHD_STAS1;  A5F0M6, SDHD_VIBC3;  
A7MYG2, SDHD_VIBCB;  Q9KL72, SDHD_VIBCH;  C3LWD9, SDHD_VIBCM;  
Q87QA2, SDHD_VIBPA;  A1JJW5, SDHD_YERE8;  Q2PGG3, SRR_ARATH;  
A0JNI4, SRR_BOVIN;  Q54HH2, SRR_DICDI;  Q9GZT4, SRR_HUMAN;  
Q9QZX7, SRR_MOUSE;  A2XWA9, SRR_ORYSI;  Q7XSN8, SRR_ORYSJ;  
Q76EQ0, SRR_RAT;  O59791, SRR_SCHPO;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
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