ENZYME entry: EC 4.3.1.26
| Accepted Name |
|---|
| Chromopyrrolate synthase.
|
| Reaction catalysed |
|---|
| 2 2-imino-3-(7-chloroindol-3-yl)propanoate <=> dichlorochromopyrrolate + ammonium |
| Cofactor(s) |
|---|
| Heme; Iron.
|
| Comment(s) |
|---|
- This enzyme catalyzes a step in the biosynthesis of rebeccamycin,
an indolocarbazole alkaloid produced by the actinobacterium
Lechevalieria aerocolonigenes.
- The enzyme is a dimeric heme-protein oxidase that catalyzes the
oxidative dimerization of two L-tryptophan-derived molecules to form
dichlorochromopyrrolic acid, the precursor for the fused six-ring
indolocarbazole scaffold of rebeccamycin.
|
| Cross-references |
|---|
| BRENDA | 4.3.1.26 |
| EC2PDB | 4.3.1.26 |
| ExplorEnz | 4.3.1.26 |
| PRIAM enzyme-specific profiles | 4.3.1.26 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.3.1.26 |
| IUBMB Enzyme Nomenclature | 4.3.1.26 |
| IntEnz | 4.3.1.26 |
| MEDLINE | Find literature relating to 4.3.1.26 |
| MetaCyc | 4.3.1.26 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-