ENZYME entry: EC 4.3.1.3

Accepted Name
Histidine ammonia-lyase.
Alternative Name(s)
Histidase.
Histidinase.
Histidine alpha-deaminase.
Reaction catalysed
L-histidine <=> urocanate + NH(3)
Comment(s)
  • Member of the aromatic amino acid lyase family, other members of which are EC 4.3.1.23, EC 4.3.1.24 and EC 4.3.1.25.
  • Catalyzes the first step in the degradation of histidine and the product, urocanic acid, is further metabolized to glutamate.
Cross-references
PROSITEPDOC00424
BRENDA4.3.1.3
EC2PDB4.3.1.3
ExplorEnz4.3.1.3
PRIAM enzyme-specific profiles4.3.1.3
KEGG Ligand Database for Enzyme Nomenclature4.3.1.3
IUBMB Enzyme Nomenclature4.3.1.3
IntEnz4.3.1.3
MEDLINEFind literature relating to 4.3.1.3
MetaCyc4.3.1.3
UniProtKB/Swiss-Prot
Q556V9, HALL_DICDI;  Q8RFC2, HUTH1_FUSNN;  Q8RDU4, HUTH2_FUSNN;  
A1TRE4, HUTH_ACIAC;  A5FZB9, HUTH_ACICJ;  Q9KWE4, HUTH_AGRRH;  
B9JDC0, HUTH_AGRRK;  Q8U8Z7, HUTH_AGRT5;  B9K288, HUTH_AGRVS;  
A6TSX0, HUTH_ALKMQ;  A8MF64, HUTH_ALKOO;  B8J950, HUTH_ANAD2;  
Q2IIV4, HUTH_ANADE;  B4UC43, HUTH_ANASK;  Q5NZX8, HUTH_AROAE;  
A7ZAE4, HUTH_BACA2;  C3P4M2, HUTH_BACAA;  C3L982, HUTH_BACAC;  
A0RH39, HUTH_BACAH;  Q81Y45, HUTH_BACAN;  B7JI80, HUTH_BACC0;  
Q733H8, HUTH_BACC1;  B7ISJ2, HUTH_BACC2;  C1EN93, HUTH_BACC3;  
B7HCD0, HUTH_BACC4;  B7HKJ1, HUTH_BACC7;  A7GR00, HUTH_BACCN;  
B9IUH0, HUTH_BACCQ;  Q81AC6, HUTH_BACCR;  Q637H8, HUTH_BACCZ;  
Q9KBE6, HUTH_BACHD;  Q6HFE9, HUTH_BACHK;  Q5WAZ6, HUTH_BACSK;  
P10944, HUTH_BACSU;  A9VPT8, HUTH_BACWK;  Q6G3U8, HUTH_BARHE;  
Q6FZP9, HUTH_BARQU;  A9IVW5, HUTH_BART1;  A7YWP4, HUTH_BOVIN;  
Q89GV3, HUTH_BRADU;  A5EQB7, HUTH_BRASB;  A4YNK7, HUTH_BRASO;  
B2SD96, HUTH_BRUA1;  Q2YIL6, HUTH_BRUA2;  Q579E8, HUTH_BRUAB;  
A9MCL0, HUTH_BRUC2;  A5VVJ6, HUTH_BRUO2;  A9WVU3, HUTH_BRUSI;  
Q8FVB4, HUTH_BRUSU;  B1YT80, HUTH_BURA4;  Q1BHY5, HUTH_BURCA;  
B1JV50, HUTH_BURCC;  A0K8U6, HUTH_BURCH;  B4EDX5, HUTH_BURCJ;  
Q0BDK6, HUTH_BURCM;  A9AGP7, HUTH_BURM1;  A3MLT7, HUTH_BURM7;  
A2SA96, HUTH_BURM9;  Q62LJ6, HUTH_BURMA;  A3NXA3, HUTH_BURP0;  
A3NBH0, HUTH_BURP6;  B2T2Y2, HUTH_BURPP;  Q63SH6, HUTH_BURPS;  
Q39EP0, HUTH_BURS3;  A4JG46, HUTH_BURVG;  Q20502, HUTH_CAEEL;  
B8H2S1, HUTH_CAUCN;  P58082, HUTH_CAUCR;  B0SYU6, HUTH_CAUSK;  
Q11E18, HUTH_CHESB;  A9WHT8, HUTH_CHLAA;  B9LLY0, HUTH_CHLSY;  
Q7P188, HUTH_CHRVO;  A8AJ15, HUTH_CITK8;  Q891Q1, HUTH_CLOTE;  
C1CWB4, HUTH_DEIDV;  Q9RZ06, HUTH_DEIRA;  Q6AKP3, HUTH_DESPS;  
Q54JI7, HUTH_DICDI;  A4W8B5, HUTH_ENT38;  Q5L310, HUTH_GEOKA;  
C5D4K1, HUTH_GEOSW;  A4IK90, HUTH_GEOTN;  Q7NCB3, HUTH_GLOVI;  
A9H863, HUTH_GLUDA;  Q5FRR8, HUTH_GLUOX;  B0R544, HUTH_HALS3;  
Q9HQD5, HUTH_HALSA;  P42357, HUTH_HUMAN;  Q0BZK2, HUTH_HYPNA;  
Q5QV30, HUTH_IDILO;  B5XZ79, HUTH_KLEP3;  A6T6L1, HUTH_KLEP7;  
Q1IRT8, HUTH_KORVE;  Q5X5I5, HUTH_LEGPA;  A5IBM2, HUTH_LEGPC;  
Q5ZVR0, HUTH_LEGPH;  Q5WWW8, HUTH_LEGPL;  B9E7E0, HUTH_MACCJ;  
Q0AP92, HUTH_MARMM;  B8II08, HUTH_METNO;  B0UQ15, HUTH_METS4;  
P35492, HUTH_MOUSE;  Q1D6R1, HUTH_MYXXD;  B2A3D9, HUTH_NATTJ;  
A6WYU8, HUTH_OCHA4;  A1AZX9, HUTH_PARDP;  B4RED8, HUTH_PHEZH;  
Q7N296, HUTH_PHOLL;  Q6LQ56, HUTH_PHOPR;  Q15X40, HUTH_PSEA6;  
B7V3J1, HUTH_PSEA8;  Q02ER8, HUTH_PSEAB;  Q9HU85, HUTH_PSEAE;  
Q8VMR3, HUTH_PSEFS;  Q3KJE6, HUTH_PSEPF;  Q88CZ7, HUTH_PSEPK;  
P21310, HUTH_PSEPU;  Q87UM1, HUTH_PSESM;  Q1Q9E4, HUTH_PSYCK;  
A1STQ3, HUTH_PSYIN;  A5WDR1, HUTH_PSYWF;  Q8XW29, HUTH_RALSO;  
P21213, HUTH_RAT;  Q983I0, HUTH_RHILO;  O31197, HUTH_RHIME;  
B6IWC6, HUTH_RHOCS;  Q2RUU3, HUTH_RHORT;  A3PK23, HUTH_RHOS1;  
Q3J289, HUTH_RHOS4;  B9KSW6, HUTH_RHOSK;  Q162E2, HUTH_ROSDO;  
Q5LRD8, HUTH_RUEPO;  B5F069, HUTH_SALA4;  A9MJE9, HUTH_SALAR;  
Q57RG6, HUTH_SALCH;  B5FP58, HUTH_SALDC;  B5QX62, HUTH_SALEP;  
B5R758, HUTH_SALG2;  B4TC45, HUTH_SALHS;  B4SZJ4, HUTH_SALNS;  
Q5PG61, HUTH_SALPA;  A9MTJ1, HUTH_SALPB;  C0PWX9, HUTH_SALPC;  
B5BC34, HUTH_SALPK;  B4TQT6, HUTH_SALSV;  Q8Z896, HUTH_SALTI;  
Q8ZQQ9, HUTH_SALTY;  Q8EKJ4, HUTH_SHEON;  A8HA91, HUTH_SHEPA;  
B8CGY5, HUTH_SHEPW;  A8G1S5, HUTH_SHESH;  B1KP55, HUTH_SHEWM;  
A9GFW6, HUTH_SORC5;  Q1GSH0, HUTH_SPHAL;  A6TXF8, HUTH_STAA2;  
Q2FKP8, HUTH_STAA3;  Q2G2P7, HUTH_STAA8;  A5INP9, HUTH_STAA9;  
Q2YUR3, HUTH_STAAB;  Q5HJY8, HUTH_STAAC;  A6QD47, HUTH_STAAE;  
P64415, HUTH_STAAM;  P64416, HUTH_STAAN;  Q6GKT7, HUTH_STAAR;  
Q6GD82, HUTH_STAAS;  A8YYT1, HUTH_STAAT;  Q8NYY3, HUTH_STAAW;  
Q4A173, HUTH_STAS1;  Q93TX3, HUTH_STIAU;  Q82I33, HUTH_STRAW;  
Q9EWW1, HUTH_STRCO;  A8AZ70, HUTH_STRGC;  P24221, HUTH_STRGR;  
P58083, HUTH_STRP1;  P0DB74, HUTH_STRP3;  Q5X9K4, HUTH_STRP6;  
Q8NZ46, HUTH_STRP8;  A2RGS5, HUTH_STRPG;  P0DB75, HUTH_STRPQ;  
B5XIY2, HUTH_STRPZ;  A3CL24, HUTH_STRSV;  Q67JH4, HUTH_SYMTH;  
Q9HLI6, HUTH_THEAC;  Q8RBH4, HUTH_THETN;  Q978N8, HUTH_THEVO;  
Q73Q56, HUTH_TREDE;  Q9KSQ4, HUTH_VIBCH;  Q5E0C6, HUTH_VIBF1;  
B5ETN1, HUTH_VIBFM;  Q87Q77, HUTH_VIBPA;  Q8DA21, HUTH_VIBVU;  
Q7MK58, HUTH_VIBVY;  Q8PLZ8, HUTH_XANAC;  Q4UTB9, HUTH_XANC8;  
B0RUX3, HUTH_XANCB;  Q8PAA7, HUTH_XANCP;  A1JSW6, HUTH_YERE8;  
Q8ZA10, HUTH_YERPE;  Q664B8, HUTH_YERPS;  Q8YD09, HUTIH_BRUME;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-