ENZYME entry: EC 4.3.2.6

Accepted Name
Gamma-L-glutamyl-butirosin B gamma-glutamyl cyclotransferase.
Reaction catalysed
Gamma-L-glutamyl-butirosin B <=> butirosin B + 5-oxoproline
Comment(s)
  • The enzyme catalyzes the last step in the biosynthesis of the aminoglycoside antibiotic butirosin B.
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the terminal gamma-L- glutamate of the side chain, releasing it as the cyclic 5-oxoproline.
Cross-references
BRENDA4.3.2.6
EC2PDB4.3.2.6
ExplorEnz4.3.2.6
PRIAM enzyme-specific profiles4.3.2.6
KEGG Ligand Database for Enzyme Nomenclature4.3.2.6
IUBMB Enzyme Nomenclature4.3.2.6
IntEnz4.3.2.6
MEDLINEFind literature relating to 4.3.2.6
MetaCyc4.3.2.6
UniProtKB/Swiss-Prot
Q4H4F0, BTRG_BACCI

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-