ENZYME entry: EC 4.3.3.6

Accepted Name
Pyridoxal 5'-phosphate synthase (glutamine hydrolyzing).
Reaction catalysed
D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine <=> pyridoxal 5'-phosphate + L-glutamate + 3 H(2)O + phosphate
Comment(s)
  • The ammonia is provided by the glutaminase subunit and channeled to the active site of the lyase subunit by a 100 A tunnel.
  • The enzyme can also use ribulose 5-phosphate and dihydroxyacetone phosphate.
  • The enzyme complex is found in aerobic bacteria, archeae, fungi and plants.
Cross-references
BRENDA4.3.3.6
EC2PDB4.3.3.6
ExplorEnz4.3.3.6
PRIAM enzyme-specific profiles4.3.3.6
KEGG Ligand Database for Enzyme Nomenclature4.3.3.6
IUBMB Enzyme Nomenclature4.3.3.6
IntEnz4.3.3.6
MEDLINEFind literature relating to 4.3.3.6
MetaCyc4.3.3.6
UniProtKB/Swiss-Prot
O80448, PDX11_ARATH;  Q69LA6, PDX11_ORYSJ;  Q8W3D0, PDX12_ORYSJ;  
Q8L940, PDX13_ARATH;  O59905, PDX1_CERNC;  Q54J47, PDX1_DICDI;  
Q9UW83, PDX1_EMENI;  Q9AT63, PDX1_GINBI;  Q39963, PDX1_HEVBR;  
Q9C1K6, PDX1_NEUCR;  Q9FT25, PDX1_PHAVU;  P0DMS0, PDX1_PLABE;  
C6KT50, PDX1_PLAF7;  O14027, PDX1_SCHPO;  Q41348, PDX1_STELP;  
Q8WPW2, PDX1_SUBDO;  Q8LAD0, PDX2_ARATH;  Q54J48, PDX2_DICDI;  
Q4PJX5, PDX2_PLABE;  Q8IIK4, PDX2_PLAF7;  A3MZT8, PDXS_ACTP2;  
B3GXB6, PDXS_ACTP7;  B0BUD0, PDXS_ACTPJ;  Q9YFK2, PDXS_AERPE;  
B7GFL8, PDXS_ANOFW;  O29742, PDXS_ARCFU;  A7Z0D3, PDXS_BACA2;  
C3P8Q3, PDXS_BACAA;  C3LIY7, PDXS_BACAC;  Q81W27, PDXS_BACAN;  
B7JJC6, PDXS_BACC0;  Q73FJ5, PDXS_BACC1;  B7IS29, PDXS_BACC2;  
C1ES17, PDXS_BACC3;  B7HII3, PDXS_BACC4;  B7HPS6, PDXS_BACC7;  
Q8L1A8, PDXS_BACCI;  A7GJS8, PDXS_BACCN;  B9IYH8, PDXS_BACCQ;  
Q81JC6, PDXS_BACCR;  Q63HF8, PDXS_BACCZ;  Q9KGN6, PDXS_BACHD;  
Q6HQ05, PDXS_BACHK;  Q65PL2, PDXS_BACLD;  A8FAD5, PDXS_BACP2;  
Q5WKW2, PDXS_BACSK;  P37527, PDXS_BACSU;  A9VM99, PDXS_BACWK;  
B8DWP6, PDXS_BIFA0;  A1A3A5, PDXS_BIFAA;  B3DT80, PDXS_BIFLD;  
Q8G574, PDXS_BIFLO;  B7GUB5, PDXS_BIFLS;  Q8RBJ3, PDXS_CALS4;  
A9WFT9, PDXS_CHLAA;  B8G663, PDXS_CHLAD;  B9LIK3, PDXS_CHLSY;  
Q97LG7, PDXS_CLOAB;  A7GH18, PDXS_CLOBL;  B1KYX5, PDXS_CLOBM;  
B8I363, PDXS_CLOCE;  Q84IL8, PDXS_CLONO;  P81356, PDXS_CLOPA;  
P60800, PDXS_CORDI;  Q8FPJ9, PDXS_COREF;  P82134, PDXS_CORGL;  
B1VDJ3, PDXS_CORU7;  Q3Z9H3, PDXS_DEHM1;  A5FS82, PDXS_DEHMB;  
Q3ZZB8, PDXS_DEHMC;  Q9RUL7, PDXS_DEIRA;  B8J2D5, PDXS_DESDA;  
B8FZR3, PDXS_DESHD;  Q24PK7, PDXS_DESHY;  B8D3X7, PDXS_DESK1;  
B5YF85, PDXS_DICT6;  B8E121, PDXS_DICTD;  B0TZ17, PDXS_FRAP2;  
Q14IU8, PDXS_FRAT1;  A7NDQ3, PDXS_FRATF;  Q2A260, PDXS_FRATH;  
B2SDL5, PDXS_FRATM;  A0Q5I1, PDXS_FRATN;  Q0BKT2, PDXS_FRATO;  
Q5NHE6, PDXS_FRATT;  O69190, PDXS_FRATU;  A4IZB5, PDXS_FRATW;  
Q8RDP7, PDXS_FUSNN;  Q5L3Y2, PDXS_GEOKA;  C5D337, PDXS_GEOSW;  
A4IJ94, PDXS_GEOTN;  Q7VL86, PDXS_HAEDU;  Q4QJU5, PDXS_HAEI8;  
A5UBN2, PDXS_HAEIE;  A5UF86, PDXS_HAEIG;  P45293, PDXS_HAEIN;  
B9LRS6, PDXS_HALLT;  Q5V1G7, PDXS_HALMA;  B0R6D5, PDXS_HALS3;  
Q9HP57, PDXS_HALSA;  Q18F41, PDXS_HALWD;  B0TAQ4, PDXS_HELMI;  
A9B891, PDXS_HERA2;  A2BLL5, PDXS_HYPBU;  Q6AFB9, PDXS_LEIXX;  
Q929R9, PDXS_LISIN;  C1KX53, PDXS_LISMC;  Q71XR3, PDXS_LISMF;  
B8DH17, PDXS_LISMH;  Q8Y5G2, PDXS_LISMO;  A0AKK8, PDXS_LISW6;  
B9E8T2, PDXS_MACCJ;  A6UWM0, PDXS_META3;  Q8TQH6, PDXS_METAC;  
Q58090, PDXS_METJA;  Q8TVL8, PDXS_METKA;  A2SPJ9, PDXS_METLZ;  
A4G086, PDXS_METM5;  A9A8I8, PDXS_METM6;  A6VI92, PDXS_METM7;  
Q8PUA5, PDXS_METMA;  Q6M115, PDXS_METMP;  A4YI11, PDXS_METS5;  
Q2NI73, PDXS_METST;  O26762, PDXS_METTH;  Q50841, PDXS_METVA;  
A6UR91, PDXS_METVS;  A0QIC8, PDXS_MYCA1;  P60795, PDXS_MYCBO;  
A1KLV6, PDXS_MYCBP;  C1AF77, PDXS_MYCBT;  B8ZUG3, PDXS_MYCLB;  
O07145, PDXS_MYCLE;  Q73WF0, PDXS_MYCPA;  A0QWG8, PDXS_MYCS2;  
A5U5V7, PDXS_MYCTA;  P9WII8, PDXS_MYCTO;  P9WII9, PDXS_MYCTU;  
Q3INE8, PDXS_NATPD;  B2A2Z7, PDXS_NATTJ;  Q5YTD8, PDXS_NOCFA;  
Q8EN03, PDXS_OCEIH;  Q6MEN8, PDXS_PARUW;  Q9CLJ6, PDXS_PASMU;  
Q6L2D8, PDXS_PICTO;  Q6A948, PDXS_PROAC;  Q9V0J7, PDXS_PYRAB;  
Q8ZUF0, PDXS_PYRAE;  A4WHH6, PDXS_PYRAR;  A3MSN0, PDXS_PYRCJ;  
Q8U0Q6, PDXS_PYRFU;  O59080, PDXS_PYRHO;  A7NQB8, PDXS_ROSCS;  
A5UY94, PDXS_ROSS1;  A8LWZ4, PDXS_SALAI;  A4X5V3, PDXS_SALTO;  
A7WYT1, PDXS_STAA1;  A6TYZ5, PDXS_STAA2;  Q2FJC1, PDXS_STAA3;  
Q2G0Q1, PDXS_STAA8;  A5IQ72, PDXS_STAA9;  Q5HIF5, PDXS_STAAC;  
A6QEH1, PDXS_STAAE;  P60797, PDXS_STAAM;  P60798, PDXS_STAAN;  
Q6GJF0, PDXS_STAAR;  Q6GBW9, PDXS_STAAS;  A8YZL5, PDXS_STAAT;  
P60799, PDXS_STAAW;  B9DKX7, PDXS_STACT;  Q5HRN5, PDXS_STAEQ;  
Q8CQV7, PDXS_STAES;  Q4L3H8, PDXS_STAHJ;  Q49V28, PDXS_STAS1;  
Q827U0, PDXS_STRAW;  Q9L286, PDXS_STRCO;  Q04JN5, PDXS_STRP2;  
B5E5W1, PDXS_STRP4;  C1C863, PDXS_STRP7;  B1ICP9, PDXS_STRPI;  
B8ZL14, PDXS_STRPJ;  Q97PX2, PDXS_STRPN;  Q8DP71, PDXS_STRR6;  
C1CF50, PDXS_STRZJ;  C1CLG7, PDXS_STRZP;  C1CQQ0, PDXS_STRZT;  
Q4J8L3, PDXS_SULAC;  C3N6C8, PDXS_SULIA;  C4KHU3, PDXS_SULIK;  
C3MQK8, PDXS_SULIL;  C3MW86, PDXS_SULIM;  C3NGV8, PDXS_SULIN;  
C3NET6, PDXS_SULIY;  Q9UWX3, PDXS_SULSO;  Q971B3, PDXS_SULTO;  
Q2LXR2, PDXS_SYNAS;  Q9HKS5, PDXS_THEAC;  C5A4G9, PDXS_THEGJ;  
Q5JFR1, PDXS_THEKO;  Q9WYU4, PDXS_THEMA;  B6YVQ7, PDXS_THEON;  
A5IJU8, PDXS_THEP1;  B0KAS1, PDXS_THEP3;  B0K4N7, PDXS_THEPX;  
B1L920, PDXS_THESQ;  Q72KG1, PDXS_THET2;  Q5SKD9, PDXS_THET8;  
Q979Y3, PDXS_THEVO;  Q73QI7, PDXS_TREDE;  Q83HM5, PDXS_TROW8;  
Q83MZ9, PDXS_TROWT;  A0LUK9, PDXT_ACIC1;  A3MZT9, PDXT_ACTP2;  
B3GXB7, PDXT_ACTP7;  B0BUD1, PDXT_ACTPJ;  Q9YFK4, PDXT_AERPE;  
B7GFL9, PDXT_ANOFW;  O29741, PDXT_ARCFU;  A1R728, PDXT_ARTAT;  
B8H9E0, PDXT_ARTCA;  A0JXB5, PDXT_ARTS2;  B6YQU3, PDXT_AZOPC;  
A7Z0D4, PDXT_BACA2;  C3P8Q4, PDXT_BACAA;  C3LIY8, PDXT_BACAC;  
A0R890, PDXT_BACAH;  Q81W26, PDXT_BACAN;  B7JJC7, PDXT_BACC0;  
Q73FJ4, PDXT_BACC1;  B7IS30, PDXT_BACC2;  C1ES18, PDXT_BACC3;  
B7HII4, PDXT_BACC4;  B7HPS7, PDXT_BACC7;  Q8L1A7, PDXT_BACCI;  
A7GJS9, PDXT_BACCN;  B9IYH9, PDXT_BACCQ;  Q81JC5, PDXT_BACCR;  
Q63HF7, PDXT_BACCZ;  Q9KGN5, PDXT_BACHD;  Q6HQ04, PDXT_BACHK;  
Q65PL1, PDXT_BACLD;  A8FAD6, PDXT_BACP2;  Q5WKW1, PDXT_BACSK;  
P37528, PDXT_BACSU;  A9VMA0, PDXT_BACWK;  A1A3A4, PDXT_BIFAA;  
Q8G575, PDXT_BIFLO;  C0ZH53, PDXT_BREBN;  B9MKY8, PDXT_CALBD;  
A8MAY1, PDXT_CALMQ;  Q8RBJ4, PDXT_CALS4;  A4XIB6, PDXT_CALS8;  
Q3A8Q0, PDXT_CARHZ;  A0RTP4, PDXT_CENSY;  A9WFU0, PDXT_CHLAA;  
B8G664, PDXT_CHLAD;  B9LIK4, PDXT_CHLSY;  A5CS10, PDXT_CLAM3;  
B0REB6, PDXT_CLAMS;  Q97LG6, PDXT_CLOAB;  A6M3G5, PDXT_CLOB8;  
B1KYX4, PDXT_CLOBM;  B8I364, PDXT_CLOCE;  B9E3V5, PDXT_CLOK1;  
A5MZY0, PDXT_CLOK5;  Q6NK10, PDXT_CORDI;  A4QCC4, PDXT_CORGB;  
Q8NS90, PDXT_CORGL;  Q4JVD5, PDXT_CORJK;  Q3Z8V9, PDXT_DEHM1;  
A5FRL6, PDXT_DEHMB;  Q3ZX06, PDXT_DEHMC;  Q1IZC9, PDXT_DEIGD;  
Q9RUL8, PDXT_DEIRA;  B1I158, PDXT_DESAP;  B8FZR4, PDXT_DESHD;  
Q24PK8, PDXT_DESHY;  A4J0G0, PDXT_DESRM;  B5YF84, PDXT_DICT6;  
B8E120, PDXT_DICTD;  B1YGC2, PDXT_EXIS2;  A7HNV0, PDXT_FERNB;  
Q0RNV0, PDXT_FRAAA;  B0TZ16, PDXT_FRAP2;  Q2JD98, PDXT_FRASC;  
A8KZF0, PDXT_FRASN;  Q14IU7, PDXT_FRAT1;  A7NDQ2, PDXT_FRATF;  
Q2A261, PDXT_FRATH;  B2SDL4, PDXT_FRATM;  A0Q5I2, PDXT_FRATN;  
Q0BKT3, PDXT_FRATO;  Q5NHE5, PDXT_FRATT;  A4IZB4, PDXT_FRATW;  
Q5L3Y1, PDXT_GEOKA;  P83813, PDXT_GEOSE;  C5D338, PDXT_GEOSW;  
A4IJ95, PDXT_GEOTN;  Q7VL87, PDXT_HAEDU;  Q4QJU4, PDXT_HAEI8;  
A5UBN1, PDXT_HAEIE;  A5UF87, PDXT_HAEIG;  P45294, PDXT_HAEIN;  
B9LSC8, PDXT_HALLT;  Q5UZW7, PDXT_HALMA;  B0R879, PDXT_HALS3;  
Q9HMD2, PDXT_HALSA;  Q18KL6, PDXT_HALWD;  A9B890, PDXT_HERA2;  
A2BLL6, PDXT_HYPBU;  A8A8T7, PDXT_IGNH4;  A6WCI3, PDXT_KINRD;  
B1L4Z3, PDXT_KORCO;  Q1IQH8, PDXT_KORVE;  C5CG73, PDXT_KOSOT;  
Q6AFB8, PDXT_LEIXX;  Q929R8, PDXT_LISIN;  C1KX54, PDXT_LISMC;  
Q71XR2, PDXT_LISMF;  B8DH16, PDXT_LISMH;  Q8Y5G1, PDXT_LISMO;  
A0AKK9, PDXT_LISW6;  A6UWZ3, PDXT_META3;  Q8TQH7, PDXT_METAC;  
A7I472, PDXT_METB6;  Q465J4, PDXT_METBF;  Q12YR6, PDXT_METBU;  
Q2FTH1, PDXT_METHJ;  Q59055, PDXT_METJA;  Q8TWH2, PDXT_METKA;  
A2SPK0, PDXT_METLZ;  A4G0R6, PDXT_METM5;  A9A909, PDXT_METM6;  
A6VHR9, PDXT_METM7;  Q8PUA4, PDXT_METMA;  A3CRE5, PDXT_METMJ;  
P0C036, PDXT_METMP;  B8GE19, PDXT_METPE;  A5UK48, PDXT_METS3;  
A4YI12, PDXT_METS5;  Q2NGI4, PDXT_METST;  O26292, PDXT_METTH;  
A0B7N4, PDXT_METTP;  A6UQT7, PDXT_METVS;  Q2RMI9, PDXT_MOOTA;  
A0QIC6, PDXT_MYCA1;  B1MCJ8, PDXT_MYCA9;  Q7TY92, PDXT_MYCBO;  
A1KLV4, PDXT_MYCBP;  C1AF75, PDXT_MYCBT;  Q9CCT5, PDXT_MYCLE;  
B2HN48, PDXT_MYCMM;  Q73WF2, PDXT_MYCPA;  A0QWH0, PDXT_MYCS2;  
A3PYU8, PDXT_MYCSJ;  A1UF87, PDXT_MYCSK;  Q1B9S6, PDXT_MYCSS;  
A5U5V5, PDXT_MYCTA;  P9WII6, PDXT_MYCTO;  P9WII7, PDXT_MYCTU;  
A0PSY6, PDXT_MYCUA;  A1T876, PDXT_MYCVP;  Q3IU60, PDXT_NATPD;  
A9A4S0, PDXT_NITMS;  Q5YTE0, PDXT_NOCFA;  A1SJA2, PDXT_NOCSJ;  
Q8EN04, PDXT_OCEIH;  Q04F27, PDXT_OENOB;  Q6MEN7, PDXT_PARUW;  
Q9CLJ5, PDXT_PASMU;  A5D6D2, PDXT_PELTS;  Q6L1R3, PDXT_PICTO;  
Q6A947, PDXT_PROAC;  Q9V0J6, PDXT_PYRAB;  Q8ZUE9, PDXT_PYRAE;  
A4WHH5, PDXT_PYRAR;  A3MSM9, PDXT_PYRCJ;  Q8TH23, PDXT_PYRFU;  
O59079, PDXT_PYRHO;  A1RU67, PDXT_PYRIL;  B1YB90, PDXT_PYRNV;  
A9WSE8, PDXT_RENSM;  Q0S1D2, PDXT_RHOJR;  C1B4C5, PDXT_RHOOB;  
A7NQB7, PDXT_ROSCS;  A5UY93, PDXT_ROSS1;  Q1AWE7, PDXT_RUBXD;  
A4FBA2, PDXT_SACEN;  A8LWZ5, PDXT_SALAI;  A4X5V4, PDXT_SALTO;  
Q02CB5, PDXT_SOLUE;  A7WYT2, PDXT_STAA1;  A6TYZ6, PDXT_STAA2;  
Q2FJC0, PDXT_STAA3;  Q2G0Q0, PDXT_STAA8;  A5IQ73, PDXT_STAA9;  
Q2YSE1, PDXT_STAAB;  Q5HIF4, PDXT_STAAC;  A6QEH2, PDXT_STAAE;  
Q99W83, PDXT_STAAM;  Q7A7A1, PDXT_STAAN;  Q6GJE9, PDXT_STAAR;  
Q6GBW8, PDXT_STAAS;  A8YZL6, PDXT_STAAT;  Q7A1R6, PDXT_STAAW;  
B9DKX8, PDXT_STACT;  Q5HRN4, PDXT_STAEQ;  Q8CQV8, PDXT_STAES;  
Q4L3H9, PDXT_STAHJ;  A3DM32, PDXT_STAMF;  Q49V29, PDXT_STAS1;  
Q81ZV5, PDXT_STRAW;  Q9L287, PDXT_STRCO;  B1W3G0, PDXT_STRGG;  
Q04JN6, PDXT_STRP2;  B5E5W0, PDXT_STRP4;  C1C862, PDXT_STRP7;  
B1ICP8, PDXT_STRPI;  B8ZL13, PDXT_STRPJ;  Q97PX3, PDXT_STRPN;  
B2IQT4, PDXT_STRPS;  Q8DP72, PDXT_STRR6;  C1CF49, PDXT_STRZJ;  
C1CLG6, PDXT_STRZP;  C1CQQ1, PDXT_STRZT;  Q4J8L2, PDXT_SULAC;  
C3N6C7, PDXT_SULIA;  C4KHU2, PDXT_SULIK;  C3MQK7, PDXT_SULIL;  
C3MW85, PDXT_SULIM;  C3NGV9, PDXT_SULIN;  C3NET5, PDXT_SULIY;  
Q9UWX4, PDXT_SULSO;  Q971B2, PDXT_SULTO;  Q2LXR3, PDXT_SYNAS;  
B7IEZ6, PDXT_THEAB;  Q9HM60, PDXT_THEAC;  Q47N39, PDXT_THEFY;  
C5A4H0, PDXT_THEGJ;  Q5JFR2, PDXT_THEKO;  A8F840, PDXT_THELT;  
A6LP41, PDXT_THEM4;  Q9WYU3, PDXT_THEMA;  B9KBI1, PDXT_THENN;  
B6YVQ8, PDXT_THEON;  A5IJU9, PDXT_THEP1;  B0KAS0, PDXT_THEP3;  
B0K4N6, PDXT_THEPX;  B1L921, PDXT_THESQ;  Q72KF8, PDXT_THET2;  
Q5SKD6, PDXT_THET8;  Q97CP5, PDXT_THEVO;  Q83HM6, PDXT_TROW8;  
Q83GK3, PDXT_TROWT;  Q0W8A8, PDXT_UNCMA;  Q03144, SNO1_YEAST;  
P53823, SNO2_YEAST;  P43544, SNO3_YEAST;  Q03148, SNZ1_YEAST;  
P53824, SNZ2_YEAST;  P43545, SNZ3_YEAST;  

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