ENZYME entry: EC 4.3.99.3

Accepted Name
7-carboxy-7-deazaguanine synthase.
Alternative Name(s)
7-carboxy-7-carbaguanine synthase.
Reaction catalysed
6-carboxy-5,6,7,8-tetrahydropterin <=> 7-carboxy-7-carbaguanine + NH(3)
Cofactor(s)
Iron-sulfur; Magnesium; S-adenosyl-L-methionine.
Comment(s)
  • The enzyme is a member of the superfamily of S-adenosyl-L-methionine- dependent radical (radical AdoMet) enzymes.
  • Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
  • The S-adenosyl-L-methionine is catalytic as it is regenerated at the end of the reaction.
  • The reaction is part of the biosynthesis pathway of queuosine.
Cross-references
BRENDA4.3.99.3
EC2PDB4.3.99.3
ExplorEnz4.3.99.3
PRIAM enzyme-specific profiles4.3.99.3
KEGG Ligand Database for Enzyme Nomenclature4.3.99.3
IUBMB Enzyme Nomenclature4.3.99.3
IntEnz4.3.99.3
MEDLINEFind literature relating to 4.3.99.3
MetaCyc4.3.99.3
UniProtKB/Swiss-Prot
A9CF16, QUEE_AGRT5;  O67826, QUEE_AQUAE;  O29808, QUEE_ARCFU;  
Q81G67, QUEE_BACCR;  O31677, QUEE_BACSU;  Q89ZC3, QUEE_BACTN;  
Q7VVJ8, QUEE_BORPE;  Q89SC0, QUEE_BRADU;  Q8K9D9, QUEE_BUCAP;  
Q0PBX7, QUEE_CAMJE;  Q9A3P3, QUEE_CAUCR;  Q8KFK8, QUEE_CHLTE;  
Q97D55, QUEE_CLOAB;  Q728E5, QUEE_DESVH;  P64555, QUEE_ECO57;  
P64554, QUEE_ECOLI;  A6H1N2, QUEE_FLAPJ;  Q74CF3, QUEE_GEOSL;  
Q7NCE3, QUEE_GLOVI;  P45097, QUEE_HAEIN;  B0R9W6, QUEE_HALS3;  
A2BJ90, QUEE_HYPBU;  Q1IHK7, QUEE_KORVE;  Q8EZ24, QUEE_LEPIN;  
Q8TIF5, QUEE_METAC;  Q2FS67, QUEE_METHJ;  Q59039, QUEE_METJA;  
Q8TX58, QUEE_METKA;  O27295, QUEE_METTH;  Q9K0Q5, QUEE_NEIMB;  
Q7V9H9, QUEE_PROMA;  Q8ZZZ0, QUEE_PYRAE;  Q7UVG8, QUEE_RHOBA;  
Q2RSY6, QUEE_RHORT;  Q9ZCV2, QUEE_RICPR;  P64556, QUEE_SHIFL;  
P73667, QUEE_SYNY3;  Q9HII0, QUEE_THEAC;  Q5JGE6, QUEE_THEKO;  

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