ENZYME entry: EC 4.4.1.1
| Accepted Name |
|---|
| Cystathionine gamma-lyase.
|
| Alternative Name(s) |
|---|
| Cystathionase. |
| Cystathioninase. |
| Cysteine desulfhydrase. |
| Cystine desulfhydrase. |
| Gamma-cystathionase. |
| Homoserine deaminase. |
| Homoserine dehydratase. |
| Reaction catalysed |
|---|
| L-cystathionine + H(2)O <=> L-cysteine + NH(3) + 2-oxobutanoate |
| Cofactor(s) |
|---|
| Pyridoxal 5'-phosphate.
|
| Comment(s) |
|---|
- Also catalyzes elimination reactions of L-homoserine to form H(2)O,
NH(3) and 2-oxobutanoate, of L-cystine, producing thiocysteine,
pyruvate and NH(3), and of L-cysteine producing pyruvate, NH(3) and
H(2)S.
- Formerly EC 4.2.1.15.
|
| Cross-references |
|---|
| PROSITE | PDOC00677 |
| BRENDA | 4.4.1.1 |
| EC2PDB | 4.4.1.1 |
| ExplorEnz | 4.4.1.1 |
| PRIAM enzyme-specific profiles | 4.4.1.1 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.4.1.1 |
| IUBMB Enzyme Nomenclature | 4.4.1.1 |
| IntEnz | 4.4.1.1 |
| MEDLINE | Find literature relating to 4.4.1.1 |
| MetaCyc | 4.4.1.1 |
| UniProtKB/Swiss-Prot |
| P55216, CGL2_CAEEL; | Q58DW2, CGL_BOVIN; | Q55DV9, CGL_DICDI; |
| P32929, CGL_HUMAN; | Q60HG7, CGL_MACFA; | Q8VCN5, CGL_MOUSE; |
| Q19QT7, CGL_PIG; | P18757, CGL_RAT; | P31373, CYS3_YEAST; |
| Q59829, CYSA_STRCO; | O05394, MCCB_BACSU; |
|
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