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ENZYME entry: EC 4.4.1.13

Accepted Name
Cysteine-S-conjugate beta-lyase.
Alternative Name(s)
L-cysteine-S-conjugate thiol-lyase (deaminating).
Reaction catalysed
An L-cysteine-S-conjugate + H(2)O <=> RSH + NH(3) + pyruvate
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme can act on a broad range of L-cysteine-S-conjugates, including aromatic conjugates such as 4-bromobenzene and 2,4- dinitrobenzene.
  • The enzyme cleaves a carbon-sulfur bond, releasing a thiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
Cross-references
BRENDA4.4.1.13
EC2PDB4.4.1.13
ExplorEnz4.4.1.13
PRIAM enzyme-specific profiles4.4.1.13
KEGG Ligand Database for Enzyme Nomenclature4.4.1.13
IUBMB Enzyme Nomenclature4.4.1.13
IntEnz4.4.1.13
MEDLINEFind literature relating to 4.4.1.13
MetaCyc4.4.1.13
UniProtKB/Swiss-Prot
Q16773, KAT1_HUMAN;  Q8BTY1, KAT1_MOUSE;  Q08415, KAT1_RAT;  
Q0P5G4, KAT3_BOVIN;  Q7T3E5, KAT3_DANRE;  Q6YP21, KAT3_HUMAN;  
Q71RI9, KAT3_MOUSE;  Q58FK9, KAT3_RAT;  Q54KM6, KAT_DICDI;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-