Expasy logo

ENZYME

ENZYME entry: EC 4.4.1.25

Accepted Name
L-cysteate sulfo-lyase
Reaction catalysed
H2O + L-cysteate <=> H(+) + NH4(+) + pyruvate + sulfite
Comment(s)
  • The enzyme cleaves a carbon-sulfur bond, releasing bisulfite and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • D-Cysteine can also act as a substrate, but more slowly.
  • It is converted into pyruvate, sulfide and ammonia.
  • The inducible enzyme from Silicibacter pomeroyi DSS-3 forms part of the cysteate-degradation pathway.
Cross-references
BRENDA4.4.1.25
EC2PDB4.4.1.25
ExplorEnz4.4.1.25
PRIAM enzyme-specific profiles4.4.1.25
KEGG Ligand Database for Enzyme Nomenclature4.4.1.25
IUBMB Enzyme Nomenclature4.4.1.25
IntEnz4.4.1.25
MEDLINEFind literature relating to 4.4.1.25
MetaCyc4.4.1.25
Rhea expert-curated reactions4.4.1.25
UniProtKB/Swiss-Prot
A3SQG3, CUYA_ROSNIQ5LL69, CUYA_RUEPO

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-