ENZYME entry: EC 4.4.1.28

Accepted Name
L-cysteine desulfidase.
Alternative Name(s)
L-cysteine desulfhydrase.
Reaction catalysed
L-cysteine + H(2)O <=> sulfide + NH(3) + pyruvate
Comment(s)
  • The enzyme from the archaeon Methanocaldococcus jannaschii contains a [4Fe-4S] cluster and is specific for L-cysteine (cf. EC 4.4.1.1).
  • It cleaves a carbon-sulfur bond releasing sulfide and the unstable enamine product 2-aminoprop-2-enoate that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The same reaction can also be catalyzed by some pyridoxal-phosphate proteins (cf. EC 4.4.1.1).
Cross-references
BRENDA4.4.1.28
EC2PDB4.4.1.28
ExplorEnz4.4.1.28
PRIAM enzyme-specific profiles4.4.1.28
KEGG Ligand Database for Enzyme Nomenclature4.4.1.28
IUBMB Enzyme Nomenclature4.4.1.28
IntEnz4.4.1.28
MEDLINEFind literature relating to 4.4.1.28
MetaCyc4.4.1.28
UniProtKB/Swiss-Prot
Q58431, CYDE_METJA;  A4FW56, CYDE_METM5;  A9A9J5, CYDE_METM6;  
A6VH54, CYDE_METM7;  Q6LX84, CYDE_METMP;  Q9M1R1, LCYD1_ARATH;  
Q9LGZ2, LCYD1_ORYSJ;  Q5JNT6, LCYD2_ORYSJ;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.4.1.-
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