ENZYME entry: EC 4.5.1.2

Accepted Name
3-chloro-D-alanine dehydrochlorinase.
Reaction catalysed
3-chloro-D-alanine + H(2)O <=> pyruvate + chloride + NH(3)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme cleaves a carbon-chlorine bond, releasing a chloride and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • The enzyme's activity can also result in beta-replacement reactions, e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D- alanine into D-cysteine and chloride.
Cross-references
BRENDA4.5.1.2
EC2PDB4.5.1.2
ExplorEnz4.5.1.2
PRIAM enzyme-specific profiles4.5.1.2
KEGG Ligand Database for Enzyme Nomenclature4.5.1.2
IUBMB Enzyme Nomenclature4.5.1.2
IntEnz4.5.1.2
MEDLINEFind literature relating to 4.5.1.2
MetaCyc4.5.1.2

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-