Due to maintenance work, this service will not be available on Monday December 12th between 07.00 am and 9.00 am CEST.

ENZYME entry: EC

Accepted Name
3-chloro-D-alanine dehydrochlorinase.
Reaction catalysed
3-chloro-D-alanine + H(2)O <=> pyruvate + chloride + NH(3)
Pyridoxal 5'-phosphate.
  • The enzyme cleaves a carbon-chlorine bond, releasing a chloride and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC
  • The enzyme's activity can also result in beta-replacement reactions, e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D- alanine into D-cysteine and chloride.
PRIAM enzyme-specific profiles4.5.1.2
KEGG Ligand Database for Enzyme Nomenclature4.5.1.2
IUBMB Enzyme Nomenclature4.5.1.2
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-