ENZYME entry: EC 4.6.1.14

Accepted Name
Glycosylphosphatidylinositol diacylglycerol-lyase.
Alternative Name(s)
(Glycosyl)phosphatidylinositol-specific phospholipase C.
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol diacylglycerol- lyase (1,2-cyclic-phosphate-forming).
Glycosyl inositol phospholipid anchor-hydrolyzing enzyme.
Glycosylphosphatidylinositol-phospholipase C.
Glycosylphosphatidylinositol-specific phospholipase C.
GPI-PLC.
GPI-specific phospholipase C.
Variant-surface-glycoprotein phospholipase C.
VSG-lipase.
Reaction catalysed
6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol <=> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol
Comment(s)
  • This enzyme is also active when O-4 of the glucosamine is substituted by carrying the oligosaccharide that can link a protein to the structure.
  • It therefore cleaves proteins from the lipid part of the glycosylphostphatidylinositol (GPI) anchors.
  • In some cases, the long-chain acyl group at the sn-1 position of glycerol is replaced by an alkyl or alk-1-enyl group.
  • In other cases, the diacylglycerol is replaced by ceramide.
  • The only characterized enzyme with this specificity is from Trypanosoma brucei, where the acyl groups are myristoyl, but the function of the trypanosome enzyme is unknown.
  • Substitution on O-2 of the inositol blocks action of this enzyme.
  • It is not identical with EC 3.1.4.50.
  • Formerly EC 3.1.4.47.
Cross-references
BRENDA4.6.1.14
EC2PDB4.6.1.14
ExplorEnz4.6.1.14
PRIAM enzyme-specific profiles4.6.1.14
KEGG Ligand Database for Enzyme Nomenclature4.6.1.14
IUBMB Enzyme Nomenclature4.6.1.14
IntEnz4.6.1.14
MEDLINEFind literature relating to 4.6.1.14
MetaCyc4.6.1.14
UniProtKB/Swiss-Prot
P09194, PHLC_TRYBB;  O15886, PHLC_TRYCR;  

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