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ENZYME entry: EC 4.6.1.16

Accepted Name
tRNA-intron lyase.
Alternative Name(s)
PretRNA lyase (intron-removing; cyclic-2',3'-phosphate-forming).
tRNA splicing endonuclease.
Reaction catalysed
PretRNA <=> a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus
Comment(s)
  • The enzyme catalyzes the final stage in the maturation of tRNA molecules.
  • Formerly EC 3.1.27.9.
Cross-references
BRENDA4.6.1.16
EC2PDB4.6.1.16
ExplorEnz4.6.1.16
PRIAM enzyme-specific profiles4.6.1.16
KEGG Ligand Database for Enzyme Nomenclature4.6.1.16
IUBMB Enzyme Nomenclature4.6.1.16
IntEnz4.6.1.16
MEDLINEFind literature relating to 4.6.1.16
MetaCyc4.6.1.16
UniProtKB/Swiss-Prot
Q9YBF1, ENDA_AERPE;  O29362, ENDA_ARCFU;  Q5UYF6, ENDA_HALMA;  
B0R7C0, ENDA_HALS3;  Q9HN82, ENDA_HALSA;  O07118, ENDA_HALVD;  
A2BIW2, ENDA_HYPBU;  Q8TGX1, ENDA_METAC;  Q46FK9, ENDA_METBF;  
Q12X51, ENDA_METBU;  Q58819, ENDA_METJA;  Q8TGZ7, ENDA_METKA;  
Q8PZI1, ENDA_METMA;  Q6LY59, ENDA_METMP;  O07165, ENDA_METTH;  
A6UPD9, ENDA_METVS;  Q74MP4, ENDA_NANEQ;  Q3IU70, ENDA_NATPD;  
Q6L1P9, ENDA_PICTO;  Q9UY33, ENDA_PYRAB;  Q8ZVI1, ENDA_PYRAE;  
A4WLV3, ENDA_PYRAR;  Q8U429, ENDA_PYRFU;  O58033, ENDA_PYRHO;  
A1RSY7, ENDA_PYRIL;  B1Y9D1, ENDA_PYRNV;  Q4JAF4, ENDA_SULAC;  
C3N6N2, ENDA_SULIA;  C4KIA4, ENDA_SULIK;  C3MQX7, ENDA_SULIL;  
C3MWW5, ENDA_SULIM;  C3NGJ0, ENDA_SULIN;  C3N746, ENDA_SULIY;  
Q97ZY3, ENDA_SULSO;  Q975R3, ENDA_SULTO;  Q9HIY5, ENDA_THEAC;  
C5A2D9, ENDA_THEGJ;  Q5JHP5, ENDA_THEKO;  B6YXU4, ENDA_THEON;  
Q97BQ3, ENDA_THEVO;  Q9M1E8, SEN21_ARATH;  Q9LSS3, SEN22_ARATH;  
Q74ZY5, SEN2_ASHGO;  Q5ZIN2, SEN2_CHICK;  Q8NCE0, SEN2_HUMAN;  
Q6P7W5, SEN2_MOUSE;  Q9P6Y2, SEN2_NEUCR;  Q5Z6B1, SEN2_ORYSJ;  
Q5M954, SEN2_RAT;  Q8TFH7, SEN2_SCHPO;  P16658, SEN2_YEAST;  
Q754T3, SEN34_ASHGO;  Q9BSV6, SEN34_HUMAN;  Q8BMZ5, SEN34_MOUSE;  
Q7SAK9, SEN34_NEUCR;  O60156, SEN34_SCHPO;  P39707, SEN34_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-