ENZYME entry: EC 4.6.1.2

Accepted Name
Guanylate cyclase.
Alternative Name(s)
Guanyl cyclase.
Guanylyl cyclase.
Reaction catalysed
GTP <=> 3',5'-cyclic GMP + diphosphate
Comment(s)
Also acts on ITP and dGTP.
Cross-references
PROSITEPDOC00425
BRENDA4.6.1.2
EC2PDB4.6.1.2
ExplorEnz4.6.1.2
PRIAM enzyme-specific profiles4.6.1.2
KEGG Ligand Database for Enzyme Nomenclature4.6.1.2
IUBMB Enzyme Nomenclature4.6.1.2
IntEnz4.6.1.2
MEDLINEFind literature relating to 4.6.1.2
MetaCyc4.6.1.2
UniProtKB/Swiss-Prot
P16066, ANPRA_HUMAN;  P18293, ANPRA_MOUSE;  P18910, ANPRA_RAT;  
P55202, ANPRB_ANGJA;  P46197, ANPRB_BOVIN;  P20594, ANPRB_HUMAN;  
Q6VVW5, ANPRB_MOUSE;  P16067, ANPRB_RAT;  Q8I4N4, DAF11_CAEEL;  
Q553Y7, GCA_DICDI;  B1Q257, GCY10_CAEEL;  Q18331, GCY11_CAEEL;  
Q19187, GCY12_CAEEL;  Q19768, GCY13_CAEEL;  Q23310, GCY14_CAEEL;  
P91550, GCY15_CAEEL;  X5M8U1, GCY17_CAEEL;  G5EFQ0, GCY18_CAEEL;  
A8XQC7, GCY19_CAEBR;  O16544, GCY19_CAEEL;  Q09435, GCY1_CAEEL;  
O62179, GCY20_CAEEL;  O16715, GCY21_CAEEL;  Q9XTY1, GCY22_CAEEL;  
G5EEE9, GCY23_CAEEL;  A0A078BQP2, GCY25_CAEEL;  Q9XU42, GCY27_CAEEL;  
Q86GV3, GCY28_CAEEL;  O62026, GCY29_CAEEL;  Q10029, GCY2_CAEEL;  
Q86C56, GCY31_CAEEL;  Q6DNF7, GCY32_CAEEL;  P90895, GCY33_CAEEL;  
P92006, GCY34_CAEEL;  O02298, GCY35_CAEEL;  Q6DNF4, GCY36_CAEEL;  
Q6DNF3, GCY37_CAEEL;  Q07553, GCY3E_DROME;  Q10028, GCY3_CAEEL;  
A8WPG9, GCY4_CAEBR;  Q23681, GCY4_CAEEL;  Q23682, GCY5_CAEEL;  
N1NVB7, GCY6_CAEEL;  H2L002, GCY7_CAEEL;  Q8INF0, GCY8E_DROME;  
Q9GYQ4, GCY8_CAEEL;  E7EAU8, GCY9_CAEEL;  P19687, GCYA1_BOVIN;  
P33402, GCYA2_HUMAN;  Q9WVI4, GCYA2_RAT;  Q4ZHS0, GCYA3_CANFA;  
Q02108, GCYA3_HUMAN;  Q9ERL9, GCYA3_MOUSE;  P19686, GCYA3_RAT;  
P16068, GCYB1_BOVIN;  Q4ZHR9, GCYB1_CANFA;  Q02153, GCYB1_HUMAN;  
O54865, GCYB1_MOUSE;  P20595, GCYB1_RAT;  O75343, GCYB2_HUMAN;  
P22717, GCYB2_RAT;  Q9VEU6, GCYDA_DROME;  Q9VEU5, GCYDB_DROME;  
Q07093, GCYH_DROME;  P11528, GCY_ARBPU;  P16065, GCY_STRPU;  
P70106, GUC2C_CAVPO;  P25092, GUC2C_HUMAN;  Q3UWA6, GUC2C_MOUSE;  
P55204, GUC2C_PIG;  P23897, GUC2C_RAT;  P55203, GUC2D_BOVIN;  
O19179, GUC2D_CANFA;  Q02846, GUC2D_HUMAN;  P51839, GUC2D_RAT;  
P52785, GUC2E_MOUSE;  P51840, GUC2E_RAT;  O02740, GUC2F_BOVIN;  
P51841, GUC2F_HUMAN;  Q5SDA5, GUC2F_MOUSE;  P51842, GUC2F_RAT;  
Q6TL19, GUC2G_MOUSE;  P55205, GUC2G_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.6.1.-
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