ENZYME entry: EC 4.7.1.1

Accepted Name
Alpha-D-ribose 1-methylphosphonate 5-phosphate C-P-lyase.
Reaction catalysed
Alpha-D-ribose 1-methylphosphonate 5-phosphate + S-adenosyl-L-methionine + reduced electron acceptor <=> alpha-D-ribose 1,2-cyclic phosphate 5-phosphate + methane + L-methionine + 5'-deoxyadenosine + electron acceptor
Cofactor(s)
Iron-sulfur; S-adenosyl-L-methionine.
Comment(s)
  • This radical SAM (AdoMet) enzyme is part of the C-P lyase complex, which is responsible for processing phophonates into usable phosphate.
  • The enzyme from the bacterium Escherichia coli can act on additional alpha-D-ribose phosphonate substrates with different substituents attached to the phosphonate phosphorus (e.g. alpha-D-ribose-1- (N-(phosphonomethyl)glycine)-5-phosphate and alpha-D-ribose-1-(2-N- acetamidomethylphosphonate)-5-phosphate).
Cross-references
BRENDA4.7.1.1
EC2PDB4.7.1.1
ExplorEnz4.7.1.1
PRIAM enzyme-specific profiles4.7.1.1
KEGG Ligand Database for Enzyme Nomenclature4.7.1.1
IUBMB Enzyme Nomenclature4.7.1.1
IntEnz4.7.1.1
MEDLINEFind literature relating to 4.7.1.1
MetaCyc4.7.1.1
UniProtKB/Swiss-Prot
P16688, PHNJ_ECOLI;  Q52987, PHNJ_RHIME;  

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