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ENZYME entry: EC 4.99.1.3

Accepted Name
Sirohydrochlorin cobaltochelatase.
Alternative Name(s)
Anaerobic cobalt chelatase.
Cobaltochelatase.
Reaction catalysed
Cobalt-sirohydrochlorin + 2 H(+) <=> sirohydrochlorin + Co(2+)
Comment(s)
  • This enzyme is a type II chelatase, being either a monomer (CbiX) or a homodimer (CibK) and being ATP-independent.
  • CbiK from Salmonella enterica uses precorrin-2 as the substrate to yield cobalt-precorrin-2.
  • The enzyme contains two histidines at the active site that are thought to be involved in the deprotonation of the tetrapyrrole substrate as well as in metal binding.
  • CbiX from Bacillus megaterium inserts cobalt at the level of sirohydrochlorin (factor-II) rather than precorrin-2.
Cross-references
BRENDA4.99.1.3
EC2PDB4.99.1.3
ExplorEnz4.99.1.3
PRIAM enzyme-specific profiles4.99.1.3
KEGG Ligand Database for Enzyme Nomenclature4.99.1.3
IUBMB Enzyme Nomenclature4.99.1.3
IntEnz4.99.1.3
MEDLINEFind literature relating to 4.99.1.3
MetaCyc4.99.1.3
UniProtKB/Swiss-Prot
Q72CB8, CBIKC_DESVH;  Q72EC8, CBIKP_DESVH;  Q05592, CBIK_SALTY;  
O29537, CBIX_ARCFU;  O87690, CBIX_BACME;  Q9HQM3, CBIX_HALSA;  
A6UWT5, CBIX_META3;  Q8TJZ5, CBIX_METAC;  P61816, CBIX_METBF;  
Q12X56, CBIX_METBU;  Q58380, CBIX_METJA;  Q8TY77, CBIX_METKA;  
Q8PZH6, CBIX_METMA;  P61819, CBIX_METMP;  O27448, CBIX_METTH;  
Q4JAI2, CBIX_SULAC;  C3MZ53, CBIX_SULIA;  C4KID1, CBIX_SULIK;  
C3MR05, CBIX_SULIL;  C3MWZ3, CBIX_SULIM;  C3NGG2, CBIX_SULIN;  
C3N773, CBIX_SULIY;  Q980A7, CBIX_SULSO;  Q975N6, CBIX_SULTO;  
Q55451, CBIX_SYNY3;  

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