ID   4.99.1.4
DE   sirohydrochlorin ferrochelatase.
CA   2 H(+) + siroheme = Fe(2+) + sirohydrochlorin.
CC   -!- This enzyme catalyzes the third of three steps leading to the
CC       formation of siroheme from uroporphyrinogen III.
CC   -!- The first step involves the donation of two S-adenosyl-L-methionine-
CC       derived methyl groups to carbons 2 and 7 of uroporphyrinogen III to
CC       form precorrin-2 (EC 2.1.1.107) and the second step involves an
CC       NAD(+)-dependent dehydrogenation to form sirohydrochlorin from
CC       precorrin-2 (EC 1.3.1.76).
CC   -!- In Saccharomyces cerevisiae, the last two steps are carried out by a
CC       single bifunctional enzyme, Met8p.
CC   -!- In some bacteria, steps 1-3 are catalyzed by a single multifunctional
CC       protein called CysG, whereas in Bacillus megaterium, three separate
CC       enzymes carry out each of the steps, with SirB being responsible for
CC       the above reaction.
DR   Q72CB8, CBIKC_DESVH;  Q72EC8, CBIKP_DESVH;  A0KLD7, CYSG1_AERHH;
DR   A4SHL4, CYSG1_AERS4;  A7MJ67, CYSG1_CROS8;  A1WWP8, CYSG1_HALHL;
DR   A6TD45, CYSG1_KLEP7;  Q6D1A4, CYSG1_PECAS;  A8G9Y3, CYSG1_SERP5;
DR   A1JJS8, CYSG1_YERE8;  A7FLY4, CYSG1_YERP3;  Q1CLS2, CYSG1_YERPN;
DR   A4TGU8, CYSG1_YERPP;  Q66EC9, CYSG1_YERPS;  A0KP37, CYSG2_AERHH;
DR   A4SRH0, CYSG2_AERS4;  A7MKK9, CYSG2_CROS8;  A1WYD5, CYSG2_HALHL;
DR   A6TF07, CYSG2_KLEP7;  Q6CZS0, CYSG2_PECAS;  A8GKQ1, CYSG2_SERP5;
DR   A1JSB7, CYSG2_YERE8;  A7FNS9, CYSG2_YERP3;  Q1CCP6, CYSG2_YERPN;
DR   A4TPZ1, CYSG2_YERPP;  Q664M6, CYSG2_YERPS;  A0KQJ4, CYSG3_AERHH;
DR   Q6F8G6, CYSG_ACIAD ;  B3GZA0, CYSG_ACTP7 ;  B0BTC2, CYSG_ACTPJ ;
DR   A6VPZ6, CYSG_ACTSZ ;  Q0VQ05, CYSG_ALCBS ;  Q0A812, CYSG_ALKEH ;
DR   C1DKY7, CYSG_AZOVD ;  Q1LTP4, CYSG_BAUCH ;  Q7VQG9, CYSG_BLOFL ;
DR   Q493N1, CYSG_BLOPB ;  Q2KWB0, CYSG_BORA1 ;  Q7WMM4, CYSG_BORBR ;
DR   Q7WB57, CYSG_BORPA ;  A9HZV6, CYSG_BORPD ;  Q7VZ77, CYSG_BORPE ;
DR   P57500, CYSG_BUCAI ;  Q7NZV7, CYSG_CHRVO ;  A8AQS4, CYSG_CITK8 ;
DR   A7ZSP4, CYSG_ECO24 ;  B7UK79, CYSG_ECO27 ;  B7MCY5, CYSG_ECO45 ;
DR   B7L4P2, CYSG_ECO55 ;  P0AEA9, CYSG_ECO57 ;  B5YTS6, CYSG_ECO5E ;
DR   B7NMD7, CYSG_ECO7I ;  B7N1F1, CYSG_ECO81 ;  B7M1S1, CYSG_ECO8A ;
DR   C4ZUM4, CYSG_ECOBW ;  B1X716, CYSG_ECODH ;  A8A5H5, CYSG_ECOHS ;
DR   A1AGQ2, CYSG_ECOK1 ;  Q0TC92, CYSG_ECOL5 ;  Q8FCW8, CYSG_ECOL6 ;
DR   B1IP96, CYSG_ECOLC ;  P0AEA8, CYSG_ECOLI ;  B7NDX8, CYSG_ECOLU ;
DR   B6I2S7, CYSG_ECOSE ;  B1LHG9, CYSG_ECOSM ;  Q1R5R3, CYSG_ECOUT ;
DR   C5BGP8, CYSG_EDWI9 ;  A4WFH1, CYSG_ENT38 ;  B7LS75, CYSG_ESCF3 ;
DR   A9H259, CYSG_GLUDA ;  Q5FP95, CYSG_GLUOX ;  Q2SJB7, CYSG_HAHCH ;
DR   Q31GG8, CYSG_HYDCU ;  Q65T49, CYSG_MANSM ;  Q606C9, CYSG_METCA ;
DR   Q1H3L5, CYSG_METFK ;  A9LZ77, CYSG_NEIM0 ;  P57001, CYSG_NEIMA ;
DR   P95370, CYSG_NEIMB ;  A1KU10, CYSG_NEIMF ;  Q0AHC1, CYSG_NITEC ;
DR   Q820Q4, CYSG_NITEU ;  Q2Y6L7, CYSG_NITMU ;  Q3JCS0, CYSG_NITOC ;
DR   Q7N8L2, CYSG_PHOLL ;  Q6LM67, CYSG_PHOPR ;  Q48H75, CYSG_PSE14 ;
DR   Q15YU1, CYSG_PSEA6 ;  A6V4H6, CYSG_PSEA7 ;  B7UW11, CYSG_PSEA8 ;
DR   Q02NA3, CYSG_PSEAB ;  Q9I0M7, CYSG_PSEAE ;  Q1IBC9, CYSG_PSEE4 ;
DR   Q4K9V8, CYSG_PSEF5 ;  C3JY53, CYSG_PSEFS ;  A4XUX3, CYSG_PSEMY ;
DR   A5W1H7, CYSG_PSEP1 ;  Q3KA85, CYSG_PSEPF ;  Q88FT3, CYSG_PSEPK ;
DR   B1JBD9, CYSG_PSEPW ;  Q87ZT0, CYSG_PSESM ;  Q3ILQ9, CYSG_PSET1 ;
DR   Q4ZRL6, CYSG_PSEU2 ;  Q4FSU1, CYSG_PSYA2 ;  Q1QAX7, CYSG_PSYCK ;
DR   A1SRP9, CYSG_PSYIN ;  A5WEG6, CYSG_PSYWF ;  A1AVU5, CYSG_RUTMC ;
DR   Q21K21, CYSG_SACD2 ;  B5F8J0, CYSG_SALA4 ;  A9MME5, CYSG_SALAR ;
DR   Q57IZ5, CYSG_SALCH ;  B5FJQ1, CYSG_SALDC ;  B5R2C7, CYSG_SALEP ;
DR   B5R7N6, CYSG_SALG2 ;  B4TKQ4, CYSG_SALHS ;  B4SVI1, CYSG_SALNS ;
DR   Q5PLV8, CYSG_SALPA ;  A9MT45, CYSG_SALPB ;  C0Q0F3, CYSG_SALPC ;
DR   B5BH22, CYSG_SALPK ;  B4TY38, CYSG_SALSV ;  Q8Z201, CYSG_SALTI ;
DR   P25924, CYSG_SALTY ;  B2U3H4, CYSG_SHIB3 ;  Q31VS0, CYSG_SHIBS ;
DR   Q32AZ8, CYSG_SHIDS ;  Q0SZU8, CYSG_SHIF8 ;  Q83JB3, CYSG_SHIFL ;
DR   Q3YWQ3, CYSG_SHISS ;  Q2NVN0, CYSG_SODGM ;  A4VLU6, CYSG_STUS1 ;
DR   Q3SG32, CYSG_THIDA ;  B8GUD3, CYSG_THISH ;  C4LAG5, CYSG_TOLAT ;
DR   A5CXE4, CYSG_VESOH ;  B2I985, CYSG_XYLF2 ;  Q9PF46, CYSG_XYLFA ;
DR   B0U4X0, CYSG_XYLFM ;  Q87AI5, CYSG_XYLFT ;  Q1C2P9, CYSG_YERPA ;
DR   Q74Y23, CYSG_YERPE ;  Q5NRM4, CYSG_ZYMMO ;  Q59292, HEMA_RUMJO ;
DR   O14172, MET8_SCHPO ;  P15807, MET8_YEAST ;  Q84JH7, SIRB_ARATH ;
DR   O34632, SIRB_BACSU ;  P61817, SIRB_PRIMG ;
//