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ENZYME

ENZYME entry: EC 4.99.1.8

Accepted Name
heme ligase
Alternative Name(s)
hemozoin synthase
Reaction catalysed
2 Fe(III)-heme b <=> beta-hematin
Comment(s)
  • This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin.
  • These organisms lack the mammalian heme oxygenase for elimination of heme.
Cross-references
BRENDA4.99.1.8
EC2PDB4.99.1.8
ExplorEnz4.99.1.8
PRIAM enzyme-specific profiles4.99.1.8
KEGG Ligand Database for Enzyme Nomenclature4.99.1.8
IUBMB Enzyme Nomenclature4.99.1.8
IntEnz4.99.1.8
MEDLINEFind literature relating to 4.99.1.8
MetaCyc4.99.1.8
Rhea expert-curated reactions4.99.1.8
UniProtKB/Swiss-Prot
Q8IL04, HDP_PLAF7

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