ENZYME entry: EC 4.99.1.8

Accepted Name
Heme ligase.
Alternative Name(s)
Hemozoin synthase.
Reaction catalysed
2 ferriprotoporphyrin IX <=> beta-hematin
Comment(s)
  • This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin.
  • These organisms lack the mammalian heme oxygenase for elimination of heme.
Cross-references
BRENDA4.99.1.8
EC2PDB4.99.1.8
ExplorEnz4.99.1.8
PRIAM enzyme-specific profiles4.99.1.8
KEGG Ligand Database for Enzyme Nomenclature4.99.1.8
IUBMB Enzyme Nomenclature4.99.1.8
IntEnz4.99.1.8
MEDLINEFind literature relating to 4.99.1.8
MetaCyc4.99.1.8
UniProtKB/Swiss-Prot
Q8IL04, HDP_PLAF7

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.99.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.99.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-