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ENZYME

ENZYME entry: EC 5.1.1.23

PURL: https://purl.expasy.org/enzyme/EC/5.1.1.23
Accepted Name
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate epimerase
Alternative Name(s)
UDP-MurNAc-L-Ala-L-Glu epimerase
Reaction catalysed
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate + ATP + H2O = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + AMP + diphosphate + H(+)
Comment(s)
  • The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyzes epimerization of the terminal L-glutamate in UDP-N-acetyl- alpha-D-muramoyl-L-alanyl-L-glutamate.
  • The reaction proceeds only in one direction and involves an adenylated intermediate.
  • The combined activity of this enzyme and EC 6.3.2.53 provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3 and EC 6.3.2.9.
Cross-references
BRENDA5.1.1.23
EC2PDB5.1.1.23
ExplorEnz5.1.1.23
KEGG Ligand Database for Enzyme Nomenclature5.1.1.23
IUBMB Enzyme Nomenclature5.1.1.23
MEDLINEFind literature relating to 5.1.1.23
MetaCyc5.1.1.23
Rhea expert-curated reactions5.1.1.23
UniProtKB/Swiss-Prot
C4RJF8, MURL_MICS3A4X982, MURL_SALTOP0DQD8, MURL_XANOM

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