ENZYME entry: EC 5.1.3.17

Accepted Name
Heparosan-N-sulfate-glucuronate 5-epimerase.
Reaction catalysed
Epimerization of D-glucuronate in heparosan-N-sulfate to L-iduronate
Comment(s)
  • The enzyme acts on D-glucosyluronate residues in N-sulfated heparosan polymers, converting them to L-iduronate, thus modifying the polymer to heparan-N-sulfate.
  • The enzyme requires that at least the N-acetylglucosamine residue linked to C-4 of the substrate has been deacetylated and N-sulfated, and activity is highest with fully N-sulfated substrate.
  • It does not act on glucuronate residues that are O-sulfated or are adjacent to N-acetylglucosamine residues that are O-sulfated at the 6 position.
  • Thus the epimerization from D-glucuronate to L-iduronate occurs after N-sulfation of glucosamine residues but before O-sulfation.
  • Not identical with EC 5.1.3.19 or with EC 5.1.3.36.
Cross-references
BRENDA5.1.3.17
EC2PDB5.1.3.17
ExplorEnz5.1.3.17
PRIAM enzyme-specific profiles5.1.3.17
KEGG Ligand Database for Enzyme Nomenclature5.1.3.17
IUBMB Enzyme Nomenclature5.1.3.17
IntEnz5.1.3.17
MEDLINEFind literature relating to 5.1.3.17
MetaCyc5.1.3.17
UniProtKB/Swiss-Prot
O18756, GLCE_BOVIN;  P46555, GLCE_CAEEL;  O94923, GLCE_HUMAN;  
Q9EPS3, GLCE_MOUSE;  

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