ENZYME entry: EC 5.1.3.23

Accepted Name
UDP-2,3-diacetamido-2,3-dideoxyglucuronic acid 2-epimerase.
Alternative Name(s)
2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronic acid 2-epimerase.
UDP-alpha-D-GlcNAc3NAcA 2-epimerase.
UDP-GlcNAc3NAcA 2-epimerase.
Reaction catalysed
UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate <=> UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronate
Comment(s)
  • Participates in the biosynthetic pathway for UDP-alpha-D-ManNAc3NAcA (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-mannuronic acid), an important precursor of the B-band lipopolysaccharide of Pseudomonas aeroginosa serotype O5 and of the band-A trisaccharide of Bordetella pertussis, both important respiratory pathogens.
  • Highly specific as UDP-alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2- acetamido-2-deoxy-alpha-D-glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucose) cannot act as substrates.
Cross-references
BRENDA5.1.3.23
EC2PDB5.1.3.23
ExplorEnz5.1.3.23
PRIAM enzyme-specific profiles5.1.3.23
KEGG Ligand Database for Enzyme Nomenclature5.1.3.23
IUBMB Enzyme Nomenclature5.1.3.23
IntEnz5.1.3.23
MEDLINEFind literature relating to 5.1.3.23
MetaCyc5.1.3.23
UniProtKB/Swiss-Prot
G3XD61, WBPI_PSEAE

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