ENZYME entry: EC 5.1.3.24

Accepted Name
N-acetylneuraminate epimerase.
Alternative Name(s)
Alpha-N-acetylneuraminic acid epimerase.
Sialic acid epimerase.
Sialic acid mutarotase.
Reaction catalysed
N-acetyl-alpha-neuraminate <=> N-acetyl-beta-neuraminate
Comment(s)
  • Sialoglycoconjugates present in vertebrates are linked exclusively by alpha-linkages and are released in alpha form during degradation.
  • This enzyme accelerates maturotation to the beta form (which also occurs as a slow spontaneous reaction), which is necessary for further metabolism by the bacteria.
  • Formerly EC 5.1.3.n1.
Cross-references
BRENDA5.1.3.24
EC2PDB5.1.3.24
ExplorEnz5.1.3.24
PRIAM enzyme-specific profiles5.1.3.24
KEGG Ligand Database for Enzyme Nomenclature5.1.3.24
IUBMB Enzyme Nomenclature5.1.3.24
IntEnz5.1.3.24
MEDLINEFind literature relating to 5.1.3.24
MetaCyc5.1.3.24
UniProtKB/Swiss-Prot
Q8CVR2, NANM1_ECOL6;  Q8CVG5, NANM2_ECOL6;  Q2YK69, NANM_BRUA2;  
Q577K1, NANM_BRUAB;  Q8YBP3, NANM_BRUME;  A5VU94, NANM_BRUO2;  
A9WYA0, NANM_BRUSI;  A7ZVK8, NANM_ECO24;  Q8X554, NANM_ECO57;  
A8A834, NANM_ECOHS;  A1AJH6, NANM_ECOK1;  Q0T900, NANM_ECOL5;  
P39371, NANM_ECOLI;  Q1R2K5, NANM_ECOUT;  Q4QP39, NANM_HAEI8;  
A5UB03, NANM_HAEIE;  A5UFV3, NANM_HAEIG;  P44544, NANM_HAEIN;  
Q9CKB7, NANM_PASMU;  A9MH34, NANM_SALAR;  Q57QM5, NANM_SALCH;  
B5R066, NANM_SALEP;  B4T2W1, NANM_SALNS;  A9N6P2, NANM_SALPB;  
B4TSP0, NANM_SALSV;  Q8Z7N0, NANM_SALTI;  Q8ZQ34, NANM_SALTY;  
Q31T32, NANM_SHIBS;  Q0SXL5, NANM_SHIF8;  Q83IN1, NANM_SHIFL;  
Q3YU63, NANM_SHISS;  A5F7B3, NANM_VIBC3;  Q9KR69, NANM_VIBCH;  
Q7MD39, NANM_VIBVY;  A1JMV0, NANM_YERE8;  A7FJ01, NANM_YERP3;  
Q1C8L8, NANM_YERPA;  Q7CI10, NANM_YERPE;  Q1CHD7, NANM_YERPN;  
A4TK48, NANM_YERPP;  Q66BP2, NANM_YERPS;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-