ENZYME entry: EC 5.1.99.6

Accepted Name
NAD(P)H-hydrate epimerase.
Alternative Name(s)
NAD(P)HX epimerase.
Reaction catalysed
  • (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide <=> (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
  • (6R)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate <=> (6S)-6-beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate
Comment(s)
  • The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.
  • Its physiological role is to convert the (R) forms to the (S) forms, which could then be restored to active dinucleotides by EC 4.2.1.93.
Cross-references
BRENDA5.1.99.6
EC2PDB5.1.99.6
ExplorEnz5.1.99.6
PRIAM enzyme-specific profiles5.1.99.6
KEGG Ligand Database for Enzyme Nomenclature5.1.99.6
IUBMB Enzyme Nomenclature5.1.99.6
IntEnz5.1.99.6
MEDLINEFind literature relating to 5.1.99.6
MetaCyc5.1.99.6
UniProtKB/Swiss-Prot
E3HVU4, NNRE_ACHXA;  Q17GW6, NNRE_AEDAE;  C0NNH7, NNRE_AJECG;  
C7RGH4, NNRE_ANAPD;  E3XA68, NNRE_ANODA;  Q7Q0G5, NNRE_ANOGA;  
Q4WUG4, NNRE_ASPFU;  Q7WGX4, NNRE_BORBR;  Q7W9T3, NNRE_BORPA;  
F4LHM0, NNRE_BORPC;  A9IJP4, NNRE_BORPD;  Q7VVH8, NNRE_BORPE;  
Q6QRN6, NNRE_BOVIN;  C3YDS7, NNRE_BRAFL;  A8X5H6, NNRE_CAEBR;  
Q9XW15, NNRE_CAEEL;  Q59VX9, NNRE_CANAL;  C4YF50, NNRE_CANAW;  
E2QRY6, NNRE_CANFA;  A0RY06, NNRE_CENSY;  A5CSB9, NNRE_CLAM3;  
B0RHY9, NNRE_CLAMS;  Q5KJ55, NNRE_CRYNJ;  Q6DHK1, NNRE_DANRE;  
E9HCD7, NNRE_DAPPU;  D8K3Q1, NNRE_DEHLB;  Q55CV0, NNRE_DICDI;  
B3N0Q8, NNRE_DROAN;  B3NW64, NNRE_DROER;  B4JJQ3, NNRE_DROGR;  
Q9W2Y3, NNRE_DROME;  B4L8C7, NNRE_DROMO;  B4GWP5, NNRE_DROPE;  
Q29FV5, NNRE_DROPS;  B4IDM2, NNRE_DROSE;  B4M2R8, NNRE_DROVI;  
B4NEH6, NNRE_DROWI;  B4PXF5, NNRE_DROYA;  B2KES3, NNRE_ELUMP;  
C4M2B8, NNRE_ENTHI;  B0RZQ3, NNRE_FINM2;  A8BQZ5, NNRE_GIAIC;  
Q8NCW5, NNRE_HUMAN;  E8R1E4, NNRE_ISOPI;  B7QDG3, NNRE_IXOSC;  
Q03NP0, NNRE_LACBA;  F4FTW6, NNRE_LACBN;  B2GER9, NNRE_LACF3;  
A5VML0, NNRE_LACRD;  B2G9W3, NNRE_LACRJ;  F8DQP1, NNRE_LACRS;  
D5TAM8, NNRE_LEGP2;  Q5X170, NNRE_LEGPA;  A5IHZ5, NNRE_LEGPC;  
Q5ZRQ9, NNRE_LEGPH;  B1MW95, NNRE_LEUCK;  D8MHV4, NNRE_LEUGT;  
D5T3F2, NNRE_LEUKI;  Q03UV9, NNRE_LEUMM;  F8HWV7, NNRE_LEUS2;  
E8N877, NNRE_MICTS;  F7FIH8, NNRE_MONDO;  Q8K4Z3, NNRE_MOUSE;  
C7Z508, NNRE_NECH7;  A7RPT4, NNRE_NEMVE;  Q7SGL3, NNRE_NEUCR;  
A9A432, NNRE_NITMS;  Q04HC3, NNRE_OENOB;  A0E3W6, NNRE_PARTE;  
E0V9D8, NNRE_PEDHC;  Q0UZH1, NNRE_PHANO;  Q0PIT9, NNRE_PIG;  
D2QYP6, NNRE_PIRSD;  F0SLK8, NNRE_PLABD;  Q8IKN4, NNRE_PLAF7;  
B3L9G8, NNRE_PLAKH;  D5SRZ4, NNRE_PLAL2;  A5K3F9, NNRE_PLAVS;  
E3KGP2, NNRE_PUCGT;  B0BNM1, NNRE_RAT;  Q7ULX4, NNRE_RHOBA;  
D5ATX8, NNRE_RHOCB;  B9KJP6, NNRE_RHOSK;  F7ZKE9, NNRE_ROSLO;  
O13725, NNRE_SCHPO;  A7F1E9, NNRE_SCLS1;  B8LCD8, NNRE_THAPS;  
D7CWZ0, NNRE_TRURR;  Q4PB52, NNRE_USTMA;  F8I1D0, NNRE_WEIKK;  
F7DL67, NNRE_XENTR;  Q6CDL0, NNRE_YARLI;  P40165, NNRE_YEAST;  
O67377, NNR_AQUAE;  O29407, NNR_ARCFU;  Q8NSS3, NNR_CORGL;  
Q83CM5, NNR_COXBU;  B8E2P6, NNR_DICTD;  P31806, NNR_ECOLI;  
Q7NIE6, NNR_GLOVI;  Q9ZJM4, NNR_HELPJ;  P56176, NNR_HELPY;  
A2BLC0, NNR_HYPBU;  B1L3W1, NNR_KORCO;  A4H7T9, NNR_LEIBR;  
A4HW65, NNR_LEIIN;  Q4QFL5, NNR_LEIMA;  Q2FT57, NNR_METHJ;  
Q58981, NNR_METJA;  Q8TX67, NNR_METKA;  O27324, NNR_METTH;  
Q2RGI2, NNR_MOOTA;  P37391, NNR_MYCLE;  P9WF10, NNR_MYCTO;  
P9WF11, NNR_MYCTU;  Q8ZV04, NNR_PYRAE;  Q2S580, NNR_SALRD;  
P74217, NNR_SYNY3;  D1BAA5, NNR_THEAS;  Q8DGC3, NNR_THEEB;  
Q9X024, NNR_THEMA;  A1S0R2, NNR_THEPD;  B5YIM0, NNR_THEYD;  
Q9KMX5, NNR_VIBCH;  

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