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ENZYME entry: EC

Accepted Name
2-hydroxymuconate tautomerase.
Alternative Name(s)
4-oxalocrotonate isomerase.
4-oxalocrotonate tautomerase.
Reaction catalysed
(2Z,4E)-2-hydroxyhexa-2,4-dienedioate <=> (3E)-2-oxohex-3-enedioate
  • Involved in the meta-cleavage pathway for the degradation of phenols, modified phenols and catechols.
  • The enol form (2Z,4E)-2-hydroxyhexa-2,4-dienedioate is produced as part of this pathway and is converted to the keto form (3E)-2-oxohex- 3-enedioate by the enzyme.
  • Another keto form, (4E)-2-oxohex-4-enedioate (4-oxalocrotonate), was originally thought to be produced by the enzyme but later shown to be produced non-enzymatically.
PRIAM enzyme-specific profiles5.3.2.6
KEGG Ligand Database for Enzyme Nomenclature5.3.2.6
IUBMB Enzyme Nomenclature5.3.2.6
MEDLINEFind literature relating to
Q01468, 4OT1_PSEPU;  Q8RQD2, 4OT2_PSEPU;  Q9Z431, 4OT3_PSEPU;  
Q93JW0, 4OT4_PSEPU;  P70994, 4OT_BACSU;  Q9RHM8, 4OT_COMTE;  
Q8KRR5, 4OT_PSEFL;  Q9ZI54, 4OT_PSEST;  P49172, 4OT_PSEUF;  

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