ENZYME entry: EC 5.3.3.12

Accepted Name
L-dopachrome isomerase.
Alternative Name(s)
DCF.
DCT.
Dopachrome conversion factor.
Dopachrome Delta(7),Delta(2)-isomerase.
Dopachrome Delta-isomerase.
Dopachrome isomerase.
Dopachrome keto-enol isomerase.
Dopachrome oxidoreductase.
Dopachrome rearranging enzyme.
Dopachrome tautomerase.
L-dopachrome-methyl ester tautomerase.
TRP.
Tyrosinase-related protein 2.
Reaction catalysed
L-dopachrome <=> 5,6-dihydroxyindole-2-carboxylate
Cofactor(s)
Zn(2+).
Comment(s)
  • Stereospecific for L-dopachrome (5,6-dioxo-2,3-5,6-tetrahydroindole- 2-carboxylate).
  • Dopachrome methyl ester is a substrate, but dopaminochrome (2,3- dihydroxyindolyl-5,6-quinone) is not (see also EC 4.1.1.84).
Cross-references
PROSITEPDOC00398
BRENDA5.3.3.12
EC2PDB5.3.3.12
ExplorEnz5.3.3.12
PRIAM enzyme-specific profiles5.3.3.12
KEGG Ligand Database for Enzyme Nomenclature5.3.3.12
IUBMB Enzyme Nomenclature5.3.3.12
IntEnz5.3.3.12
MEDLINEFind literature relating to 5.3.3.12
MetaCyc5.3.3.12
UniProtKB/Swiss-Prot
P91850, MIFH_BRUMA;  P81530, MIFH_TRIMR;  P81529, MIFH_TRISP;  
P81748, MIFH_TRITR;  O44786, MIFH_WUCBA;  P80177, MIF_BOVIN;  
Q02960, MIF_CHICK;  P14174, MIF_HUMAN;  Q4R549, MIF_MACFA;  
Q6DN04, MIF_MACMU;  O55052, MIF_MERUN;  P34884, MIF_MOUSE;  
P80928, MIF_PIG;  P30904, MIF_RAT;  Q1ZZU7, MIF_SHEEP;  
Q76BK2, MIF_XENLA;  A9JSE7, MIF_XENTR;  Q95119, TYRP2_BOVIN;  
O93505, TYRP2_CHICK;  P40126, TYRP2_HUMAN;  P29812, TYRP2_MOUSE;  
Q4R1H1, TYRP2_PIG;  

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