ENZYME entry: EC 5.3.3.14

Accepted Name
Trans-2-decenoyl-[acyl-carrier-protein] isomerase.
Alternative Name(s)
Beta-hydroxydecanoyl thioester dehydrase.
Trans-2,cis-3-decenoyl-ACP isomerase.
Trans-2-decenoyl-ACP isomerase.
Reaction catalysed
Trans-dec-2-enoyl-[acyl-carrier-protein] <=> cis-dec-3-enoyl-[acyl-carrier-protein]
Comment(s)
  • While the enzyme from Escherichia coli is highly specific for the 10-carbon enoyl-ACP, the enzyme from Streptococcus pneumoniae can also use the 12-carbon enoyl-ACP as substrate in vitro but not 14- or 16-carbon enoyl-ACPs.
  • ACP can be replaced by either CoA or N-acetylcysteamine thioesters.
  • The cis-3-enoyl product is required to form unsaturated fatty acids, such as palmitoleic acid and cis-vaccenic acid, in dissociated (or type II) fatty-acid biosynthesis.
Cross-references
BRENDA5.3.3.14
EC2PDB5.3.3.14
ExplorEnz5.3.3.14
PRIAM enzyme-specific profiles5.3.3.14
KEGG Ligand Database for Enzyme Nomenclature5.3.3.14
IUBMB Enzyme Nomenclature5.3.3.14
IntEnz5.3.3.14
MEDLINEFind literature relating to 5.3.3.14
MetaCyc5.3.3.14
UniProtKB/Swiss-Prot
A3N3I3, FABA_ACTP2;  B3H2V8, FABA_ACTP7;  B0BTG8, FABA_ACTPJ;  
A6VPA5, FABA_ACTSZ;  B9JGS3, FABA_AGRRK;  Q7D235, FABA_AGRT5;  
B9JYL4, FABA_AGRVS;  Q0VRB5, FABA_ALCBS;  B6ELS3, FABA_ALISL;  
Q0A8W4, FABA_ALKEH;  C1DLY7, FABA_AZOVD;  Q1LT61, FABA_BAUCH;  
Q7U352, FABA_BLOFL;  Q492P4, FABA_BLOPB;  Q89WC3, FABA_BRADU;  
A5E877, FABA_BRASB;  A4YJF9, FABA_BRASO;  B2S9G5, FABA_BRUA1;  
Q2YQQ8, FABA_BRUA2;  Q57A93, FABA_BRUAB;  A9MA02, FABA_BRUC2;  
C0RG54, FABA_BRUMB;  P64103, FABA_BRUME;  A5VTB9, FABA_BRUO2;  
B0CK19, FABA_BRUSI;  P64104, FABA_BRUSU;  B8GVZ8, FABA_CAUCN;  
Q9A246, FABA_CAUCR;  B0T7B6, FABA_CAUSK;  B3PK88, FABA_CELJU;  
Q1R0D9, FABA_CHRSD;  A8AIC5, FABA_CITK8;  Q47Z14, FABA_COLP3;  
A7MEX0, FABA_CROS8;  A7ZK57, FABA_ECO24;  B7UN33, FABA_ECO27;  
B7MHQ6, FABA_ECO45;  B7LE54, FABA_ECO55;  P0A6Q4, FABA_ECO57;  
B5YT84, FABA_ECO5E;  B7NM20, FABA_ECO7I;  B7MS65, FABA_ECO81;  
B7M883, FABA_ECO8A;  C4ZQ80, FABA_ECOBW;  B1X8Q8, FABA_ECODH;  
A7ZYQ6, FABA_ECOHS;  Q0TJA7, FABA_ECOL5;  Q8FJ83, FABA_ECOL6;  
B1IVX8, FABA_ECOLC;  P0A6Q3, FABA_ECOLI;  B7N3B6, FABA_ECOLU;  
B6I928, FABA_ECOSE;  B1LJQ9, FABA_ECOSM;  Q1RDR0, FABA_ECOUT;  
C5BD83, FABA_EDWI9;  A4W8W6, FABA_ENT38;  B2VDE7, FABA_ERWT9;  
B7LNW4, FABA_ESCF3;  Q7U343, FABA_HAEDU;  Q4QKK1, FABA_HAEI8;  
A5UEY7, FABA_HAEIG;  P45159, FABA_HAEIN;  B8F8M2, FABA_HAEPS;  
Q2S8H5, FABA_HAHCH;  A1WT00, FABA_HALHL;  C4K8W9, FABA_HAMD5;  
Q0I3F9, FABA_HISS1;  Q0BWN5, FABA_HYPNA;  Q5QYY0, FABA_IDILO;  
B5XY51, FABA_KLEP3;  A6T748, FABA_KLEP7;  Q65TA9, FABA_MANSM;  
Q0AK52, FABA_MARMM;  A6W357, FABA_MARMS;  Q11BB9, FABA_MESSB;  
Q603C9, FABA_METCA;  Q1H026, FABA_METFK;  Q1QS54, FABA_NITHX;  
Q3J9C3, FABA_NITOC;  Q3SWN9, FABA_NITWN;  A6WWV7, FABA_OCHA4;  
B6JCR2, FABA_OLICO;  Q9CNE8, FABA_PASMU;  Q6D6D7, FABA_PECAS;  
C6DKY2, FABA_PECCP;  Q7MB46, FABA_PHOLL;  Q6LR96, FABA_PHOPR;  
B4EVD3, FABA_PROMH;  Q48K61, FABA_PSE14;  Q15UB1, FABA_PSEA6;  
A6V7I3, FABA_PSEA7;  B7UVB1, FABA_PSEA8;  Q02K95, FABA_PSEAB;  
O33877, FABA_PSEAE;  Q1I7M6, FABA_PSEE4;  Q4KFX0, FABA_PSEF5;  
C3K743, FABA_PSEFS;  Q3IGG9, FABA_PSEHT;  A4XV59, FABA_PSEMY;  
A5W140, FABA_PSEP1;  Q3K8F5, FABA_PSEPF;  B0KNV6, FABA_PSEPG;  
Q88FC4, FABA_PSEPK;  B1JAU1, FABA_PSEPW;  Q883Y6, FABA_PSESM;  
Q4ZUV9, FABA_PSEU2;  A4VKR6, FABA_PSEU5;  Q98BH8, FABA_RHILO;  
Q92SV8, FABA_RHIME;  C3MC75, FABA_RHISN;  Q2J2I6, FABA_RHOP2;  
Q07V18, FABA_RHOP5;  P61450, FABA_RHOPA;  Q21CG2, FABA_RHOPB;  
Q13EM9, FABA_RHOPS;  B3QAA3, FABA_RHOPT;  Q21M18, FABA_SACD2;  
B5F1V1, FABA_SALA4;  A9MHT5, FABA_SALAR;  Q57QT6, FABA_SALCH;  
B5FQZ7, FABA_SALDC;  B5QZF7, FABA_SALEP;  B5R6C0, FABA_SALG2;  
B4TDZ4, FABA_SALHS;  B4T1Z7, FABA_SALNS;  Q5PGD2, FABA_SALPA;  
A9N6X4, FABA_SALPB;  C0Q8D8, FABA_SALPC;  B5BBL3, FABA_SALPK;  
B4TSI0, FABA_SALSV;  P64106, FABA_SALTI;  P64105, FABA_SALTY;  
A8GCL5, FABA_SERP5;  A1S606, FABA_SHEAM;  B8E711, FABA_SHEB2;  
A3D5P5, FABA_SHEB5;  A6WPK1, FABA_SHEB8;  A9L586, FABA_SHEB9;  
Q12LD1, FABA_SHEDO;  Q07ZR8, FABA_SHEFN;  B0TIX2, FABA_SHEHH;  
A3QDY5, FABA_SHELP;  Q8EFV9, FABA_SHEON;  A8H3Y6, FABA_SHEPA;  
A4Y5X9, FABA_SHEPC;  B8CPF2, FABA_SHEPW;  A0KVM1, FABA_SHESA;  
A8FW54, FABA_SHESH;  Q0HJZ4, FABA_SHESM;  Q0HW95, FABA_SHESR;  
A1RKL7, FABA_SHESW;  B1KDN5, FABA_SHEWM;  B2TTU1, FABA_SHIB3;  
Q31YL7, FABA_SHIBS;  Q32HV2, FABA_SHIDS;  P0A6Q5, FABA_SHIFL;  
Q3Z3G7, FABA_SHISS;  A6UF38, FABA_SINMW;  Q2NU74, FABA_SODGM;  
B4SIF4, FABA_STRM5;  B2FLR1, FABA_STRMK;  C5BQA1, FABA_TERTT;  
Q31E87, FABA_THICR;  A5F850, FABA_VIBC3;  A7N0M3, FABA_VIBCB;  
Q9KS00, FABA_VIBCH;  C3LMG6, FABA_VIBCM;  Q5E5A9, FABA_VIBF1;  
B5FE24, FABA_VIBFM;  Q87PC5, FABA_VIBPA;  Q8D9H3, FABA_VIBVU;  
Q7M7J5, FABA_VIBVY;  Q8D2Q4, FABA_WIGBR;  Q8PGJ2, FABA_XANAC;  
Q3BP41, FABA_XANC5;  Q4UQI1, FABA_XANC8;  B0RVP4, FABA_XANCB;  
Q8PCW9, FABA_XANCP;  Q2P7N0, FABA_XANOM;  Q5H4V4, FABA_XANOR;  
B2I7H0, FABA_XYLF2;  Q9PFT5, FABA_XYLFA;  B0U452, FABA_XYLFM;  
Q87B86, FABA_XYLFT;  A1JMS5, FABA_YERE8;  A7FJT3, FABA_YERP3;  
Q1CA31, FABA_YERPA;  Q8ZG80, FABA_YERPE;  A9R7H1, FABA_YERPG;  
Q1CGK4, FABA_YERPN;  Q66CF3, FABA_YERPS;  Q8DSN0, FABM_STRMU;  
Q8DR19, FABM_STRR6;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.3.3.-
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