ENZYME entry: EC 5.3.99.3
| Accepted Name |
|---|
| Prostaglandin-E synthase.
|
| Alternative Name(s) |
|---|
| Endoperoxide isomerase. |
| PGE isomerase. |
| PGH-PGE isomerase. |
| Prostaglandin-H(2) E-isomerase. |
| Reaction catalysed |
|---|
| (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate <=> (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate |
| Cofactor(s) |
|---|
| Glutathione.
|
| Comment(s) |
|---|
| Brings about the opening of the epidioxy bridge.
|
| Cross-references |
|---|
| BRENDA | 5.3.99.3 |
| EC2PDB | 5.3.99.3 |
| ExplorEnz | 5.3.99.3 |
| PRIAM enzyme-specific profiles | 5.3.99.3 |
| KEGG Ligand Database for Enzyme Nomenclature | 5.3.99.3 |
| IUBMB Enzyme Nomenclature | 5.3.99.3 |
| IntEnz | 5.3.99.3 |
| MEDLINE | Find literature relating to 5.3.99.3 |
| MetaCyc | 5.3.99.3 |
| UniProtKB/Swiss-Prot |
| Q66LN0, PGES2_BOVIN; | Q7ZUC7, PGES2_DANRE; | Q9H7Z7, PGES2_HUMAN; |
| Q9N0A4, PGES2_MACFA; | Q8BWM0, PGES2_MOUSE; | Q95L14, PTGES_BOVIN; |
| A0SYQ0, PTGES_CANFA; | Q8HZJ2, PTGES_HORSE; | O14684, PTGES_HUMAN; |
| Q6PWL6, PTGES_MACFA; | Q9JM51, PTGES_MOUSE; | Q3ZBF7, TEBP_BOVIN; |
| Q90955, TEBP_CHICK; | Q15185, TEBP_HUMAN; | Q6PWL5, TEBP_MACFA; |
| Q9R0Q7, TEBP_MOUSE; | Q5NVM4, TEBP_PONAB; | P83868, TEBP_RAT; |
|
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