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ENZYME entry: EC 5.3.99.4

Accepted Name
Prostaglandin-I synthase.
Alternative Name(s)
PGI(2) synthase.
PGI(2) synthetase.
Prostacyclin synthase.
Reaction catalysed
(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate <=> (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate
Cofactor(s)
Heme-thiolate.
Comment(s)
Converts prostaglandin H(2) into prostaglandin I(2) (prostacyclin).
Cross-references
PROSITEPDOC00081
BRENDA5.3.99.4
EC2PDB5.3.99.4
ExplorEnz5.3.99.4
PRIAM enzyme-specific profiles5.3.99.4
KEGG Ligand Database for Enzyme Nomenclature5.3.99.4
IUBMB Enzyme Nomenclature5.3.99.4
IntEnz5.3.99.4
MEDLINEFind literature relating to 5.3.99.4
MetaCyc5.3.99.4
UniProtKB/Swiss-Prot
Q29626, PTGIS_BOVIN;  F1RE08, PTGIS_DANRE;  Q16647, PTGIS_HUMAN;  
O35074, PTGIS_MOUSE;  Q62969, PTGIS_RAT;  

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