ENZYME entry: EC 5.4.2.12

Accepted Name
Phosphoglycerate mutase (2,3-diphosphoglycerate-independent).
Alternative Name(s)
2,3-diphosphoglycerate-independent phosphoglycerate mutase.
Cofactor independent phosphoglycerate mutase.
Phosphoglycerate phosphomutase.
Phosphoglyceromutase.
Reaction catalysed
2-phospho-D-glycerate <=> 3-phospho-D-glycerate
Cofactor(s)
Cobalt cation or Mn(2+).
Comment(s)
  • The enzymes from higher plants, algae, fungi, nematodes, sponges, coelenterates, myriapods, arachnids, echinoderms, archaea and some bacteria (particularly Gram-positive) have maximum activity in the absence of 2,3-bisphospho-D-glycerate.
  • Cf. EC 5.4.2.11.
  • The reaction involves a phosphotransferase reaction to serine followed by transfer back to the glycerate at the other position.
  • Both metal ions are involved in the reaction.
  • Formerly EC 2.7.5.3 and EC 5.4.2.1.
Cross-references
PROSITEPDOC00158
BRENDA5.4.2.12
EC2PDB5.4.2.12
ExplorEnz5.4.2.12
PRIAM enzyme-specific profiles5.4.2.12
KEGG Ligand Database for Enzyme Nomenclature5.4.2.12
IUBMB Enzyme Nomenclature5.4.2.12
IntEnz5.4.2.12
MEDLINEFind literature relating to 5.4.2.12
MetaCyc5.4.2.12
UniProtKB/Swiss-Prot
O28523, APGM1_ARCFU;  Q59007, APGM1_METJA;  O27628, APGM1_METTH;  
O28847, APGM2_ARCFU;  Q60326, APGM2_METJA;  O26518, APGM2_METTH;  
Q9YBI2, APGM_AERPE;  O66820, APGM_AQUAE;  Q1IW58, APGM_DEIGD;  
Q9RSA0, APGM_DEIRA;  Q74C57, APGM_GEOSL;  A8AC98, APGM_IGNH4;  
A6UTF2, APGM_META3;  P58812, APGM_METAC;  Q46E58, APGM_METBF;  
Q12UL5, APGM_METBU;  P58813, APGM_METKA;  A2SR62, APGM_METLZ;  
A4FW85, APGM_METM5;  A9A9M4, APGM_METM6;  A6VH25, APGM_METM7;  
Q8PX04, APGM_METMA;  A3CSK8, APGM_METMJ;  Q6LXB3, APGM_METMP;  
B8GFN7, APGM_METPE;  A5UKY4, APGM_METS3;  A4YIX4, APGM_METS5;  
Q2NES7, APGM_METST;  A0B6L2, APGM_METTP;  A6UQ84, APGM_METVS;  
Q6KZJ6, APGM_PICTO;  Q9V2M6, APGM_PYRAB;  Q8ZVE4, APGM_PYRAE;  
A4WL27, APGM_PYRAR;  A3MWR8, APGM_PYRCJ;  P58814, APGM_PYRFU;  
O57742, APGM_PYRHO;  A1RTD5, APGM_PYRIL;  B1Y9H0, APGM_PYRNV;  
Q4JAH5, APGM_SULAC;  C3MZ46, APGM_SULIA;  C4KIC4, APGM_SULIK;  
C3MQZ8, APGM_SULIL;  C3MWY6, APGM_SULIM;  C3NGG9, APGM_SULIN;  
C3N766, APGM_SULIY;  Q980A0, APGM_SULSO;  Q975P3, APGM_SULTO;  
B7IDT4, APGM_THEAB;  Q9HL27, APGM_THEAC;  C5A4S1, APGM_THEGJ;  
Q5JI21, APGM_THEKO;  A6LMV5, APGM_THEM4;  Q9X295, APGM_THEMA;  
B9K857, APGM_THENN;  A5ILK6, APGM_THEP1;  B1LAP9, APGM_THESQ;  
Q72GG0, APGM_THET2;  Q5SM27, APGM_THET8;  Q979H8, APGM_THEVO;  
Q8TMI6, GPMI1_METAC;  Q46D52, GPMI1_METBF;  Q8TIY2, GPMI2_METAC;  
Q46AE4, GPMI2_METBF;  B0CA77, GPMI_ACAM1;  A9NF91, GPMI_ACHLI;  
Q6FFD5, GPMI_ACIAD;  A4ST23, GPMI_AERS4;  Q8UAA5, GPMI_AGRFC;  
B2UMU5, GPMI_AKKM8;  Q5PAE9, GPMI_ANAMM;  Q2GKV7, GPMI_ANAPZ;  
Q3MF89, GPMI_ANAVT;  Q06464, GPMI_ANTSP;  A8EW05, GPMI_ARCB4;  
Q2NJ40, GPMI_AYWBP;  A0RKS4, GPMI_BACAH;  Q81X77, GPMI_BACAN;  
Q72XY4, GPMI_BACC1;  A7GUR8, GPMI_BACCN;  Q815K7, GPMI_BACCR;  
Q631M1, GPMI_BACCZ;  Q5LIL0, GPMI_BACFN;  Q64ZN5, GPMI_BACFR;  
Q9K716, GPMI_BACHD;  Q6HBF2, GPMI_BACHK;  Q65EN1, GPMI_BACLD;  
D5DNA8, GPMI_BACMD;  A7Z8Y2, GPMI_BACMF;  D5DVF4, GPMI_BACMQ;  
A8FHJ1, GPMI_BACP2;  Q5WDK8, GPMI_BACSK;  P39773, GPMI_BACSU;  
Q8A287, GPMI_BACTN;  A6L050, GPMI_BACV8;  Q4VWF8, GPMI_BRUMA;  
G5EFZ1, GPMI_CAEEL;  A8FKM1, GPMI_CAMJ8;  A7H4U3, GPMI_CAMJD;  
Q9PI71, GPMI_CAMJE;  A1VYF1, GPMI_CAMJJ;  Q5HW32, GPMI_CAMJR;  
B3PGV8, GPMI_CELJU;  A9WJ95, GPMI_CHLAA;  B8GBF7, GPMI_CHLAD;  
B9LBA2, GPMI_CHLSY;  Q1R1J7, GPMI_CHRSD;  Q7NSR8, GPMI_CHRVO;  
Q97L53, GPMI_CLOAB;  A7FQN9, GPMI_CLOB1;  A6LR07, GPMI_CLOB8;  
A7G9Y2, GPMI_CLOBL;  A5N2N6, GPMI_CLOK5;  A0PYP3, GPMI_CLONN;  
Q0TQY9, GPMI_CLOP1;  Q8XKU2, GPMI_CLOPE;  A9KPF4, GPMI_CLOPH;  
Q0STD7, GPMI_CLOPS;  Q898R1, GPMI_CLOTE;  A3DBQ2, GPMI_CLOTH;  
Q47VY2, GPMI_COLP3;  A9KF70, GPMI_COXBN;  A9N970, GPMI_COXBR;  
Q83BH2, GPMI_COXBU;  A7MID1, GPMI_CROS8;  B8HVP2, GPMI_CYAP4;  
B7KGG1, GPMI_CYAP7;  B7K189, GPMI_CYAP8;  B1I0X9, GPMI_DESAP;  
Q72BL6, GPMI_DESVH;  A8LKJ5, GPMI_DINSH;  A7ZTG6, GPMI_ECO24;  
Q8XDE9, GPMI_ECO57;  A8A677, GPMI_ECOHS;  A1AHE9, GPMI_ECOK1;  
Q0TBJ4, GPMI_ECOL5;  Q8FCA6, GPMI_ECOL6;  B1IZH8, GPMI_ECOLC;  
P37689, GPMI_ECOLI;  Q3YRU6, GPMI_EHRCJ;  Q2GGW3, GPMI_EHRCR;  
Q5FFL8, GPMI_EHRRG;  Q5HB16, GPMI_EHRRW;  A4W533, GPMI_ENT38;  
A5FJ26, GPMI_FLAJ1;  A6H1H2, GPMI_FLAPJ;  B0TYM8, GPMI_FRAP2;  
Q14GR4, GPMI_FRAT1;  A7NDJ7, GPMI_FRATF;  Q2A2B1, GPMI_FRATH;  
A0Q5M6, GPMI_FRATN;  Q0BKX8, GPMI_FRATO;  Q5NFB1, GPMI_FRATT;  
A4IZ68, GPMI_FRATW;  Q5KVE6, GPMI_GEOKA;  Q9X519, GPMI_GEOSE;  
Q747Q8, GPMI_GEOSL;  A4ISP5, GPMI_GEOTN;  Q7NMK9, GPMI_GLOVI;  
Q5FU33, GPMI_GLUOX;  Q6B8L5, GPMI_GRATL;  Q2SMA7, GPMI_HAHCH;  
Q5UXB9, GPMI_HALMA;  B8CYG0, GPMI_HALOH;  Q9HNY7, GPMI_HALSA;  
Q18GK9, GPMI_HALWD;  Q17X03, GPMI_HELAH;  Q7VGZ8, GPMI_HELHP;  
Q1CSQ0, GPMI_HELPH;  Q9ZKM7, GPMI_HELPJ;  P56196, GPMI_HELPY;  
A9AYE8, GPMI_HERA2;  Q5QZA9, GPMI_IDILO;  Q1ISS4, GPMI_KORVE;  
C1DDB1, GPMI_LARHH;  Q1MPK8, GPMI_LAWIP;  Q5X7P2, GPMI_LEGPA;  
A5IH96, GPMI_LEGPC;  Q5ZY71, GPMI_LEGPH;  Q5WZ43, GPMI_LEGPL;  
Q72VB8, GPMI_LEPIC;  P59173, GPMI_LEPIN;  Q928I2, GPMI_LISIN;  
Q71WX0, GPMI_LISMF;  Q8Y4I4, GPMI_LISMO;  A0ALE0, GPMI_LISW6;  
A0LDF3, GPMI_MAGMM;  Q6F0W3, GPMI_MESFL;  Q12UT0, GPMI_METBU;  
Q1GZ82, GPMI_METFK;  Q8PYF8, GPMI_METMA;  B0JLN5, GPMI_MICAN;  
Q2RLT9, GPMI_MOOTA;  Q49006, GPMI_MYCCT;  Q7NAQ5, GPMI_MYCGA;  
P47669, GPMI_MYCGE;  Q5ZZU2, GPMI_MYCH2;  Q4A7D1, GPMI_MYCH7;  
Q4A992, GPMI_MYCHJ;  Q6Y8Q8, GPMI_MYCHP;  Q6KHV9, GPMI_MYCMO;  
Q6MSF0, GPMI_MYCMS;  Q8EW33, GPMI_MYCPE;  P75167, GPMI_MYCPN;  
Q98QA7, GPMI_MYCPU;  Q4A5A8, GPMI_MYCS5;  Q1DCX8, GPMI_MYXXD;  
Q3IS17, GPMI_NATPD;  Q3JF23, GPMI_NITOC;  B2ITL6, GPMI_NOSP7;  
Q8YPL2, GPMI_NOSS1;  P59174, GPMI_OCEIH;  I6LDA6, GPMI_ONCVO;  
Q6YQT8, GPMI_ONYPE;  A6LFB1, GPMI_PARD8;  A1B4Z9, GPMI_PARDP;  
Q3A1E5, GPMI_PELCD;  Q181T7, GPMI_PEPD6;  Q6LVL2, GPMI_PHOPR;  
P51379, GPMI_PORPU;  A2C4I0, GPMI_PROM1;  A2C700, GPMI_PROM3;  
Q7VA78, GPMI_PROMA;  Q7V5U5, GPMI_PROMM;  Q7V051, GPMI_PROMP;  
Q46J72, GPMI_PROMT;  Q48C87, GPMI_PSE14;  Q15PS5, GPMI_PSEA6;  
A6VDP9, GPMI_PSEA7;  Q02EN5, GPMI_PSEAB;  Q9HU53, GPMI_PSEAE;  
Q1IG62, GPMI_PSEE4;  Q4KJR8, GPMI_PSEF5;  Q3IIE4, GPMI_PSEHT;  
A4Y077, GPMI_PSEMY;  A5WA89, GPMI_PSEP1;  Q3KJH9, GPMI_PSEPF;  
B0KN11, GPMI_PSEPG;  Q88CX4, GPMI_PSEPK;  P52832, GPMI_PSESM;  
Q4ZLR0, GPMI_PSEU2;  Q4FTU8, GPMI_PSYA2;  A1SZI3, GPMI_PSYIN;  
Q1XDA8, GPMI_PYRYE;  Q7UFG7, GPMI_RHOBA;  Q6NCX7, GPMI_RHOPA;  
A3PMX9, GPMI_RHOS1;  Q3IZB8, GPMI_RHOS4;  A4WWV3, GPMI_RHOS5;  
B9KN62, GPMI_RHOSK;  Q16D84, GPMI_ROSDO;  Q5LLW1, GPMI_RUEPO;  
Q1GCX7, GPMI_RUEST;  A1AXW7, GPMI_RUTMC;  Q21NH1, GPMI_SACD2;  
Q57IC9, GPMI_SALCH;  Q5PBZ2, GPMI_SALPA;  A9MVK6, GPMI_SALPB;  
Q2S026, GPMI_SALRD;  Q8Z2F0, GPMI_SALTI;  Q8ZL56, GPMI_SALTY;  
A8GLC2, GPMI_SERP5;  A1S1L6, GPMI_SHEAM;  A3DAN0, GPMI_SHEB5;  
A6WHC7, GPMI_SHEB8;  A9KUB8, GPMI_SHEB9;  Q12HV5, GPMI_SHEDO;  
Q07VW8, GPMI_SHEFN;  B0TLE6, GPMI_SHEHH;  A3QJM4, GPMI_SHELP;  
P59175, GPMI_SHEON;  A8HAE0, GPMI_SHEPA;  A4Y1E3, GPMI_SHEPC;  
A0KR77, GPMI_SHESA;  A8G1U9, GPMI_SHESH;  Q0HP91, GPMI_SHESM;  
Q0I0Q6, GPMI_SHESR;  A1RQ95, GPMI_SHESW;  Q31V09, GPMI_SHIBS;  
Q329P2, GPMI_SHIDS;  P59176, GPMI_SHIFL;  Q3YVX7, GPMI_SHISS;  
Q5HHP2, GPMI_STAAC;  P64269, GPMI_STAAM;  P64270, GPMI_STAAN;  
Q6GIL5, GPMI_STAAR;  Q6GB55, GPMI_STAAS;  Q8NXL5, GPMI_STAAW;  
Q5HQV1, GPMI_STAEQ;  Q8CPY4, GPMI_STAES;  Q4L4K6, GPMI_STAHJ;  
Q49W02, GPMI_STAS1;  Q9L214, GPMI_STRCO;  Q30Q40, GPMI_SULDN;  
Q67SW0, GPMI_SYMTH;  Q31R18, GPMI_SYNE7;  Q2JSV1, GPMI_SYNJA;  
Q2JIE9, GPMI_SYNJB;  B1XJ47, GPMI_SYNP2;  Q5N381, GPMI_SYNP6;  
Q7U8U2, GPMI_SYNPX;  P74507, GPMI_SYNY3;  P59177, GPMI_THEEB;  
B9KYT9, GPMI_THERP;  Q31E77, GPMI_THICR;  Q3SGA3, GPMI_THIDA;  
Q8L2S1, GPMI_TOBBP;  Q117D6, GPMI_TRIEI;  B1AIH0, GPMI_UREP2;  
Q9PQW1, GPMI_UREPA;  B5ZAY8, GPMI_UREU1;  A5CVF0, GPMI_VESOH;  
A5F3N4, GPMI_VIBC3;  A7MX70, GPMI_VIBCB;  Q9KV22, GPMI_VIBCH;  
C3LR68, GPMI_VIBCM;  Q5E8E9, GPMI_VIBF1;  B5FFX7, GPMI_VIBFM;  
Q87KZ5, GPMI_VIBPA;  B7VHQ4, GPMI_VIBTL;  Q8DCW1, GPMI_VIBVU;  
Q7MGZ2, GPMI_VIBVY;  Q73GR4, GPMI_WOLPM;  Q7M7W9, GPMI_WOLSU;  
Q5GSN3, GPMI_WOLTR;  A1JHY1, GPMI_YERE8;  A7FCU8, GPMI_YERP3;  
Q1C282, GPMI_YERPA;  Q8ZJN0, GPMI_YERPE;  Q1CD17, GPMI_YERPN;  
A4TSC2, GPMI_YERPP;  Q66GC2, GPMI_YERPS;  O04499, PMG1_ARATH;  
Q9M9K1, PMG2_ARATH;  P30792, PMGI_MAIZE;  Q42908, PMGI_MESCR;  
O24246, PMGI_PRUDU;  P35493, PMGI_RICCO;  P35494, PMGI_TOBAC;  

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