ENZYME entry: EC 5.4.2.2

Accepted Name
Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).
Alternative Name(s)
Glucose phosphomutase.
Phosphoglucose mutase.
Reaction catalysed
Alpha-D-glucose 1-phosphate <=> alpha-D-glucose 6-phosphate
Comment(s)
  • Maximum activity is only obtained in the presence of alpha-D-glucose 1,6-bisphosphate.
  • This bisphosphate is an intermediate in the reaction, being formed by transfer of a phosphate residue from the enzyme to the substrate, but the dissociation of bisphosphate from the enzyme complex is much slower than the overall isomerization.
  • Also, more slowly, catalyzes the interconversion of 1-phosphate and 6-phosphate isomers of many other alpha-D-hexoses, and the interconversion of alpha-D-ribose 1-phosphate and 5-phosphate.
  • Cf. EC 5.4.2.5.
  • Formerly EC 2.7.5.1.
Cross-references
PROSITEPDOC00589
BRENDA5.4.2.2
EC2PDB5.4.2.2
ExplorEnz5.4.2.2
PRIAM enzyme-specific profiles5.4.2.2
KEGG Ligand Database for Enzyme Nomenclature5.4.2.2
IUBMB Enzyme Nomenclature5.4.2.2
IntEnz5.4.2.2
MEDLINEFind literature relating to 5.4.2.2
MetaCyc5.4.2.2
UniProtKB/Swiss-Prot
Q02E40, ALGC_PSEAB;  P26276, ALGC_PSEAE;  Q88C93, ALGC_PSEPK;  
Q88BD4, ALGC_PSESM;  P18159, PGCA_BACSU;  Q2FE11, PGCA_STAA3;  
Q2FVC1, PGCA_STAA8;  Q2YW66, PGCA_STAAB;  Q5HD61, PGCA_STAAC;  
Q99RE2, PGCA_STAAM;  Q7A3K7, PGCA_STAAN;  Q6GDU9, PGCA_STAAR;  
Q6G6I3, PGCA_STAAS;  Q8NUV4, PGCA_STAAW;  Q5HLD2, PGCA_STAEQ;  
Q8CN38, PGCA_STAES;  Q4L9R5, PGCA_STAHJ;  Q49WH7, PGCA_STAS1;  
Q08DP0, PGM1_BOVIN;  Q23919, PGM1_DICDI;  P36871, PGM1_HUMAN;  
Q4R5E4, PGM1_MACFA;  Q9D0F9, PGM1_MOUSE;  P47244, PGM1_PARTE;  
P00949, PGM1_RABIT;  P38652, PGM1_RAT;  P33401, PGM1_YEAST;  
Q54UQ2, PGM2_DICDI;  Q96G03, PGM2_HUMAN;  Q7TSV4, PGM2_MOUSE;  
O02606, PGM2_PARTE;  Q5RFI8, PGM2_PONAB;  P37012, PGM2_YEAST;  
O49299, PGMC1_ARATH;  P93804, PGMC1_MAIZE;  Q9SGC1, PGMC2_ARATH;  
P93805, PGMC2_MAIZE;  Q9SNX2, PGMC_BROIN;  P93262, PGMC_MESCR;  
Q9SM60, PGMC_PEA;  Q9ZSQ4, PGMC_POPTN;  Q9M4G4, PGMC_SOLTU;  
Q68BJ6, PGMMM_THEKO;  Q9SCY0, PGMP_ARATH;  Q9SMM0, PGMP_BRANA;  
Q9SM59, PGMP_PEA;  Q9M4G5, PGMP_SOLTU;  Q4WY53, PGM_ASPFU;  
P57749, PGM_ASPOR;  Q9VUY9, PGM_DROME;  Q7KHA1, PGM_DROSI;  
P36938, PGM_ECOLI;  Q9P931, PGM_EMENI;  O18719, PGM_ENTDI;  
O15820, PGM_ENTHI;  P38569, PGM_KOMXY;  P40390, PGM_NEIGO;  
P57002, PGM_NEIMA;  P40391, PGM_NEIMB;  P39671, PGM_RHIRD;  
O74374, PGM_SCHPO;  B0RVK5, XANA_XANCB;  P0C7J2, XANA_XANCP;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-