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ENZYME entry: EC 5.4.3.2

Accepted Name
Lysine 2,3-aminomutase.
Reaction catalysed
L-lysine <=> (3S)-3,6-diaminohexanoate
Cofactor(s)
Iron-sulfur.
Comment(s)
  • This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
  • It contains pyridoxal phosphate and a [4Fe-4S] cluster and binds an exchangeable S-adenosyl-L-methionine molecule.
  • Activity in vitro requires a strong reductant such as dithionite and strictly anaerobic conditions.
  • A 5'-deoxyadenosyl radical is generated during the reaction cycle by reductive cleavage of S-adenosyl-L-methionine, mediated by the iron- sulfur cluster.
  • S-adenosyl-L-methionine is regenerated at the end of the reaction.
Cross-references
BRENDA5.4.3.2
EC2PDB5.4.3.2
ExplorEnz5.4.3.2
PRIAM enzyme-specific profiles5.4.3.2
KEGG Ligand Database for Enzyme Nomenclature5.4.3.2
IUBMB Enzyme Nomenclature5.4.3.2
IntEnz5.4.3.2
MEDLINEFind literature relating to 5.4.3.2
MetaCyc5.4.3.2
UniProtKB/Swiss-Prot
Q8PYC9, ABLA_METMA;  Q6LYX4, ABLA_METMP;  E3PRJ8, KAMA_ACESD;  
O34676, KAMA_BACSU;  Q9XBQ8, KAMA_CLOSU;  Q8RHX4, KAMA_FUSNN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.-.-
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