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ENZYME

ENZYME entry: EC 5.4.4.5

Accepted Name
9,12-octadecadienoate 8-hydroperoxide 8R-isomerase
Alternative Name(s)
(8R,9Z,12Z)-8-hydroperoxy-9,12-octadecadienoate mutase ((5S,8R,9Z,12Z)- 5,8-dihydroxy-9,12-octadecadienoate-forming)
Reaction catalysed
(8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate <=> (5S,8R,9Z,12Z)-5,8-dihydroxyoctadeca-9,12-dienoate
Comment(s)
  • The bifunctional enzyme from Aspergillus nidulans uses different heme domains to catalyze two separate reactions.
  • Linoleic acid is oxidized within the N-terminal heme peroxidase domain to (8R,9Z,12Z)-8-hydroperoxyoctadeca-9,12-dienoate (cf. EC 1.13.11.60), which is subsequently isomerized to (5S,8R,9Z,12Z)- 5,8-dihydroxyoctadeca-9,12-dienoate within the C-terminal P450 heme thiolate domain.
Cross-references
BRENDA5.4.4.5
EC2PDB5.4.4.5
ExplorEnz5.4.4.5
PRIAM enzyme-specific profiles5.4.4.5
KEGG Ligand Database for Enzyme Nomenclature5.4.4.5
IUBMB Enzyme Nomenclature5.4.4.5
IntEnz5.4.4.5
MEDLINEFind literature relating to 5.4.4.5
MetaCyc5.4.4.5
Rhea expert-curated reactions5.4.4.5
UniProtKB/Swiss-Prot
B0Y6R2, PPOA_ASPFCQ4WPX2, PPOA_ASPFUQ6RET3, PPOA_EMEND
G5EB19, PPOA_EMENI

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