ENZYME entry: EC 5.4.99.25

Accepted Name
tRNA pseudouridine(55) synthase.
Alternative Name(s)
Psi(55) synthase.
Psi(55) tRNA pseudouridine synthase.
tRNA pseudouridine 55 synthase.
tRNA Psi(55) synthase.
Reaction catalysed
tRNA uridine(55) <=> tRNA pseudouridine(55)
Comment(s)
  • Pseudourine synthase TruB from Escherichia coli specifically modifies uridine(55) in tRNA molecules.
  • The bifunctional archaeal enzyme also catalyzes the pseudouridylation of uridine(54).
  • It is not known whether the enzyme from Escherichia coli can also act on position 54 in vitro, since this position is occupied in E.coli tRNAs by thymine.
Cross-references
BRENDA5.4.99.25
EC2PDB5.4.99.25
ExplorEnz5.4.99.25
PRIAM enzyme-specific profiles5.4.99.25
KEGG Ligand Database for Enzyme Nomenclature5.4.99.25
IUBMB Enzyme Nomenclature5.4.99.25
IntEnz5.4.99.25
MEDLINEFind literature relating to 5.4.99.25
MetaCyc5.4.99.25
UniProtKB/Swiss-Prot
O59721, PUS4_SCHPO;  P48567, PUS4_YEAST;  B0CCH1, TRUB_ACAM1;  
A9NGE6, TRUB_ACHLI;  Q6F7I5, TRUB_ACIAD;  A3N007, TRUB_ACTP2;  
A6VNE2, TRUB_ACTSZ;  Q9YDC3, TRUB_AERPE;  A4SJR7, TRUB_AERS4;  
Q8UJ53, TRUB_AGRT5;  B6ENE4, TRUB_ALISL;  A8MFB1, TRUB_ALKOO;  
Q5PAY2, TRUB_ANAMM;  Q2GJV3, TRUB_ANAPZ;  Q3M356, TRUB_ANAVT;  
O66922, TRUB_AQUAE;  O30001, TRUB_ARCFU;  Q5NZR9, TRUB_AROAE;  
A1R520, TRUB_ARTAT;  A0JUU8, TRUB_ARTS2;  Q2NIZ2, TRUB_AYWBP;  
A1K7B7, TRUB_AZOSB;  A7Z4T7, TRUB_BACA2;  A0RHI1, TRUB_BACAH;  
P59873, TRUB_BACAN;  Q732R2, TRUB_BACC1;  A7GRE0, TRUB_BACCN;  
Q812X9, TRUB_BACCR;  Q636L6, TRUB_BACCZ;  Q5LJ29, TRUB_BACFN;  
Q650L8, TRUB_BACFR;  Q9KA80, TRUB_BACHD;  Q6HF05, TRUB_BACHK;  
Q65JH8, TRUB_BACLD;  A8FDD4, TRUB_BACP2;  Q5WFU5, TRUB_BACSK;  
P32732, TRUB_BACSU;  Q8A2U2, TRUB_BACTN;  A6KZJ9, TRUB_BACV8;  
A1UU52, TRUB_BARBK;  Q6G5F5, TRUB_BARHE;  Q6G0P4, TRUB_BARQU;  
A9IMS8, TRUB_BART1;  Q1LSL0, TRUB_BAUCH;  Q6MMS4, TRUB_BDEBA;  
B3DQF2, TRUB_BIFLD;  Q8CY45, TRUB_BIFLO;  B7GNA1, TRUB_BIFLS;  
P59877, TRUB_BLOFL;  Q493T5, TRUB_BLOPB;  Q2KXZ0, TRUB_BORA1;  
Q0SM48, TRUB_BORAP;  P65853, TRUB_BORBR;  O51743, TRUB_BORBU;  
B7J0P9, TRUB_BORBZ;  Q65ZX0, TRUB_BORGA;  P59874, TRUB_BORPA;  
P65852, TRUB_BORPE;  Q89WB1, TRUB_BRADU;  Q2YQR5, TRUB_BRUA2;  
Q57A98, TRUB_BRUAB;  A9M9Z6, TRUB_BRUC2;  Q8YEB5, TRUB_BRUME;  
A5VTB4, TRUB_BRUO2;  B0CK13, TRUB_BRUSI;  P59876, TRUB_BRUSU;  
P57456, TRUB_BUCAI;  Q8K9H3, TRUB_BUCAP;  Q89AF6, TRUB_BUCBP;  
A3MJW6, TRUB_BURM7;  Q62KL1, TRUB_BURMA;  A3NUL2, TRUB_BURP0;  
Q3JSY7, TRUB_BURP1;  A3N8W0, TRUB_BURP6;  Q63TQ0, TRUB_BURPS;  
Q39H28, TRUB_BURS3;  A4XL67, TRUB_CALS8;  A7ZE50, TRUB_CAMC1;  
A7GZ93, TRUB_CAMC5;  A8FMF5, TRUB_CAMJ8;  A7H2Q5, TRUB_CAMJD;  
Q9PNJ2, TRUB_CAMJE;  A1W089, TRUB_CAMJJ;  Q5HU02, TRUB_CAMJR;  
Q3ABA1, TRUB_CARHZ;  P58063, TRUB_CAUCR;  B0T173, TRUB_CAUSK;  
Q11BC6, TRUB_CHESB;  Q5L629, TRUB_CHLAB;  Q3AQK9, TRUB_CHLCH;  
Q254H2, TRUB_CHLFF;  Q9PKU2, TRUB_CHLMU;  Q9Z8L9, TRUB_CHLPN;  
B0B9K2, TRUB_CHLT2;  B3QZ05, TRUB_CHLT3;  B0BB81, TRUB_CHLTB;  
Q8KFS9, TRUB_CHLTE;  O84096, TRUB_CHLTR;  Q1QSZ2, TRUB_CHRSD;  
Q7MBF7, TRUB_CHRVO;  A8AQ55, TRUB_CITK8;  Q97I48, TRUB_CLOAB;  
A7GG03, TRUB_CLOBL;  A5N845, TRUB_CLOK5;  A0Q0Q4, TRUB_CLONN;  
Q0TPS0, TRUB_CLOP1;  Q8XJS1, TRUB_CLOPE;  A9KNW1, TRUB_CLOPH;  
Q0SSD7, TRUB_CLOPS;  Q895J5, TRUB_CLOTE;  Q482T7, TRUB_COLP3;  
C3PH13, TRUB_CORA7;  P60343, TRUB_CORDI;  Q8FPB3, TRUB_COREF;  
A4QEY6, TRUB_CORGB;  Q8NP46, TRUB_CORGL;  Q4JV56, TRUB_CORJK;  
A9KBM3, TRUB_COXBN;  A9N8V4, TRUB_COXBR;  Q4AAX7, TRUB_COXBU;  
A7MQD9, TRUB_CROS8;  Q46ZP3, TRUB_CUPPJ;  B3R1E2, TRUB_CUPTR;  
B7KGX7, TRUB_CYAP7;  Q47D96, TRUB_DECAR;  Q3Z7U5, TRUB_DEHM1;  
A5FQR4, TRUB_DEHMB;  Q3ZXU5, TRUB_DEHMC;  C1D1L3, TRUB_DEIDV;  
Q1J0C1, TRUB_DEIGD;  Q9RUQ9, TRUB_DEIRA;  Q30WI7, TRUB_DESAG;  
Q6AJY7, TRUB_DESPS;  Q72ER4, TRUB_DESVH;  B8DN09, TRUB_DESVM;  
A8LL26, TRUB_DINSH;  A7ZS63, TRUB_ECO24;  P60342, TRUB_ECO57;  
A8A4Y2, TRUB_ECOHS;  A1AG71, TRUB_ECOK1;  Q0TCU3, TRUB_ECOL5;  
P60341, TRUB_ECOL6;  B1IQV5, TRUB_ECOLC;  P60340, TRUB_ECOLI;  
Q1R6H2, TRUB_ECOUT;  Q3YSC6, TRUB_EHRCJ;  Q2GGA2, TRUB_EHRCR;  
Q5FHK7, TRUB_EHRRG;  Q5HBH8, TRUB_EHRRW;  A4WEY1, TRUB_ENT38;  
Q9RB36, TRUB_FLAJ1;  B0TXH9, TRUB_FRAP2;  Q14G67, TRUB_FRAT1;  
A7NAR1, TRUB_FRATF;  Q2A4N1, TRUB_FRATH;  A0Q7W5, TRUB_FRATN;  
Q0BN06, TRUB_FRATO;  Q5NER4, TRUB_FRATT;  A4IWL0, TRUB_FRATW;  
Q8R5X8, TRUB_FUSNN;  Q5L0I5, TRUB_GEOKA;  Q39VA3, TRUB_GEOMG;  
P60344, TRUB_GEOSL;  A4IME0, TRUB_GEOTN;  A5GF89, TRUB_GEOUR;  
Q7MBB8, TRUB_GLOVI;  A9HF26, TRUB_GLUDA;  Q5FQM1, TRUB_GLUOX;  
P59878, TRUB_HAEDU;  Q4QK43, TRUB_HAEI8;  A5UBU2, TRUB_HAEIE;  
A5UF28, TRUB_HAEIG;  P45142, TRUB_HAEIN;  Q2SML1, TRUB_HAHCH;  
A1WXU9, TRUB_HALHL;  Q5UXH1, TRUB_HALMA;  B0R686, TRUB_HALS3;  
Q9HPA4, TRUB_HALSA;  C4K3E8, TRUB_HAMD5;  Q7U330, TRUB_HELHP;  
B0THR7, TRUB_HELMI;  Q8GB99, TRUB_HELMO;  Q0I3P3, TRUB_HISS1;  
B0UU15, TRUB_HISS2;  Q5QTZ0, TRUB_IDILO;  Q28K11, TRUB_JANSC;  
A6TEI5, TRUB_KLEP7;  B1L793, TRUB_KORCO;  Q5FJN8, TRUB_LACAC;  
Q03QT7, TRUB_LACBA;  Q038M8, TRUB_LACC3;  B3WER2, TRUB_LACCB;  
Q1G9Q1, TRUB_LACDA;  Q049V7, TRUB_LACDB;  Q044B5, TRUB_LACGA;  
Q74IT0, TRUB_LACJO;  Q9CGH0, TRUB_LACLA;  A2RL47, TRUB_LACLM;  
Q02Z55, TRUB_LACLS;  Q88VL5, TRUB_LACPL;  A5VJE2, TRUB_LACRD;  
Q1WUF2, TRUB_LACS1;  Q38W87, TRUB_LACSS;  Q5X1C5, TRUB_LEGPA;  
A5IHU5, TRUB_LEGPC;  Q5ZRV6, TRUB_LEGPH;  Q5WT38, TRUB_LEGPL;  
Q6AG41, TRUB_LEIXX;  Q72NX5, TRUB_LEPIC;  Q8CXU1, TRUB_LEPIN;  
Q92C26, TRUB_LISIN;  Q71ZZ4, TRUB_LISMF;  Q8Y7F3, TRUB_LISMO;  
A0AIC9, TRUB_LISW6;  Q65SL2, TRUB_MANSM;  A1U5Z8, TRUB_MARAV;  
Q0AK64, TRUB_MARMM;  A6VU31, TRUB_MARMS;  Q6F1I4, TRUB_MESFL;  
A6UWC6, TRUB_META3;  Q8TRR5, TRUB_METAC;  Q46GC3, TRUB_METBF;  
Q609C2, TRUB_METCA;  Q1GXD4, TRUB_METFK;  Q57612, TRUB_METJA;  
Q8TZ08, TRUB_METKA;  A4G0N3, TRUB_METM5;  A9A8X7, TRUB_METM6;  
A6VHV2, TRUB_METM7;  Q8PV20, TRUB_METMA;  Q6LWM3, TRUB_METMP;  
O26140, TRUB_METTH;  B0JJJ5, TRUB_MICAN;  Q2RJM2, TRUB_MOOTA;  
A0QIX1, TRUB_MYCA1;  B1MD72, TRUB_MYCA9;  P62189, TRUB_MYCBO;  
A1KMD6, TRUB_MYCBP;  Q2SSF2, TRUB_MYCCT;  P59879, TRUB_MYCGA;  
Q601U7, TRUB_MYCH2;  Q9Z5I4, TRUB_MYCLE;  Q6KHH8, TRUB_MYCMO;  
Q6MTR0, TRUB_MYCMS;  Q73VW3, TRUB_MYCPA;  Q8CXQ2, TRUB_MYCPE;  
Q98Q19, TRUB_MYCPU;  A3PY88, TRUB_MYCSJ;  A1UET1, TRUB_MYCSK;  
Q1BA81, TRUB_MYCSS;  A5U6E6, TRUB_MYCTA;  P9WHP6, TRUB_MYCTO;  
P9WHP7, TRUB_MYCTU;  A0PQD9, TRUB_MYCUA;  P60346, TRUB_NANEQ;  
Q5F8W8, TRUB_NEIG1;  B4RMB1, TRUB_NEIG2;  Q9JTX5, TRUB_NEIMA;  
Q9JYY1, TRUB_NEIMB;  Q820P2, TRUB_NITEU;  Q2Y7W4, TRUB_NITMU;  
Q3J9B8, TRUB_NITOC;  A6Q522, TRUB_NITSB;  Q3SWP7, TRUB_NITWN;  
Q5YSE0, TRUB_NOCFA;  Q8YWR1, TRUB_NOSS1;  Q2G5F3, TRUB_NOVAD;  
Q8CXG9, TRUB_OCEIH;  A6WWW3, TRUB_OCHA4;  Q04ED7, TRUB_OENOB;  
Q6YQY6, TRUB_ONYPE;  B1ZX46, TRUB_OPITP;  A6LEL7, TRUB_PARD8;  
A1B5U1, TRUB_PARDP;  Q6MD66, TRUB_PARUW;  Q9CMQ7, TRUB_PASMU;  
Q6D9A3, TRUB_PECAS;  Q03FS1, TRUB_PEDPA;  Q3A4A3, TRUB_PELCD;  
Q3B200, TRUB_PELLD;  A5D2S3, TRUB_PELTS;  Q18BH7, TRUB_PEPD6;  
Q7MAY1, TRUB_PHOLL;  Q6LUJ0, TRUB_PHOPR;  Q6L1A0, TRUB_PICTO;  
Q6A7P0, TRUB_PROAC;  A3PEI1, TRUB_PROM0;  A2C4C0, TRUB_PROM1;  
A8G6F8, TRUB_PROM2;  A2BY54, TRUB_PROM5;  Q319E0, TRUB_PROM9;  
P59880, TRUB_PROMA;  P59881, TRUB_PROMM;  P59882, TRUB_PROMP;  
A2BSS0, TRUB_PROMS;  Q46JB9, TRUB_PROMT;  A4SGG0, TRUB_PROVI;  
Q48E79, TRUB_PSE14;  Q15V70, TRUB_PSEA6;  A6VCJ9, TRUB_PSEA7;  
Q02FT0, TRUB_PSEAB;  P72154, TRUB_PSEAE;  Q1IF41, TRUB_PSEE4;  
Q4KIF4, TRUB_PSEF5;  Q3IJ75, TRUB_PSEHT;  A4XYD8, TRUB_PSEMY;  
A5W985, TRUB_PSEP1;  Q3KI82, TRUB_PSEPF;  B0KHX6, TRUB_PSEPG;  
Q4ZNR4, TRUB_PSEU2;  A4VPN8, TRUB_PSEU5;  Q4FVL3, TRUB_PSYA2;  
Q1QEP3, TRUB_PSYCK;  A1ST47, TRUB_PSYIN;  Q9V1A5, TRUB_PYRAB;  
Q8ZYB3, TRUB_PYRAE;  A4WH37, TRUB_PYRAR;  A3MS77, TRUB_PYRCJ;  
Q7LWY0, TRUB_PYRFU;  O59357, TRUB_PYRHO;  A1RTL7, TRUB_PYRIL;  
B1YA64, TRUB_PYRNV;  Q1LLR8, TRUB_RALME;  B2UAA5, TRUB_RALPJ;  
Q8XZV4, TRUB_RALSO;  Q2KDZ7, TRUB_RHIEC;  Q1MN41, TRUB_RHIL3;  
Q98BI6, TRUB_RHILO;  Q92SW2, TRUB_RHIME;  P59883, TRUB_RHOBA;  
P60345, TRUB_RHOPA;  Q2RMR8, TRUB_RHORT;  A3PNF6, TRUB_RHOS1;  
Q3IYU1, TRUB_RHOS4;  A4WWP4, TRUB_RHOS5;  Q0S212, TRUB_RHOSR;  
C3PNK4, TRUB_RICAE;  A8GNM0, TRUB_RICAH;  A8GWV0, TRUB_RICB8;  
Q1RIG2, TRUB_RICBR;  A8EYU0, TRUB_RICCK;  Q92HV5, TRUB_RICCN;  
Q4ULJ9, TRUB_RICFE;  Q9ZD46, TRUB_RICPR;  C4K0F2, TRUB_RICPU;  
B0BXR2, TRUB_RICRO;  A8GS98, TRUB_RICRS;  Q68WN3, TRUB_RICTY;  
Q16CE8, TRUB_ROSDO;  Q5LLT4, TRUB_RUEPO;  Q1GKJ9, TRUB_RUEST;  
Q21H63, TRUB_SACD2;  A9MP38, TRUB_SALAR;  Q57JI1, TRUB_SALCH;  
Q5PLB2, TRUB_SALPA;  A9N730, TRUB_SALPB;  Q8Z3H9, TRUB_SALTI;  
Q8ZLT2, TRUB_SALTY;  A8G909, TRUB_SERP5;  A1S464, TRUB_SHEAM;  
B8E6N4, TRUB_SHEB2;  A3D7K4, TRUB_SHEB5;  A6WRG6, TRUB_SHEB8;  
A9KZW9, TRUB_SHEB9;  Q12QH9, TRUB_SHEDO;  Q086H0, TRUB_SHEFN;  
B0TQA0, TRUB_SHEHH;  A3QGU3, TRUB_SHELP;  A8H738, TRUB_SHEPA;  
A4Y9B8, TRUB_SHEPC;  B8CKH5, TRUB_SHEPW;  A0KTZ8, TRUB_SHESA;  
Q0HLF9, TRUB_SHESM;  Q0HXR3, TRUB_SHESR;  A1RGX7, TRUB_SHESW;  
B1KRQ8, TRUB_SHEWM;  Q31W45, TRUB_SHIBS;  Q32BG7, TRUB_SHIDS;  
Q0T0B5, TRUB_SHIF8;  Q83MJ8, TRUB_SHIFL;  Q3YX75, TRUB_SHISS;  
A6UF31, TRUB_SINMW;  Q2NW21, TRUB_SODGM;  Q01SZ5, TRUB_SOLUE;  
A7X1Q5, TRUB_STAA1;  A6U190, TRUB_STAA2;  Q2FHG7, TRUB_STAA3;  
Q2G2Q3, TRUB_STAA8;  A5ISF5, TRUB_STAA9;  Q2YXP5, TRUB_STAAB;  
Q5HGG0, TRUB_STAAC;  A6QGH0, TRUB_STAAE;  P65854, TRUB_STAAM;  
P65855, TRUB_STAAN;  Q6GHG4, TRUB_STAAR;  Q6G9U2, TRUB_STAAS;  
A8Z3V1, TRUB_STAAT;  Q8NWZ0, TRUB_STAAW;  Q5HPS0, TRUB_STAEQ;  
Q8CMM6, TRUB_STAES;  Q4L5X4, TRUB_STAHJ;  Q49X59, TRUB_STAS1;  
Q3K189, TRUB_STRA1;  P65856, TRUB_STRA3;  P65857, TRUB_STRA5;  
Q82K56, TRUB_STRAW;  Q9Z528, TRUB_STRCO;  A8AX28, TRUB_STRGC;  
B1VYN2, TRUB_STRGG;  Q8DU15, TRUB_STRMU;  P65858, TRUB_STRP1;  
Q04KA7, TRUB_STRP2;  P0DD48, TRUB_STRP3;  Q5XBX7, TRUB_STRP6;  
P65859, TRUB_STRP8;  Q1JBI5, TRUB_STRPB;  Q1JLG7, TRUB_STRPC;  
Q1JGK3, TRUB_STRPD;  Q1J6C1, TRUB_STRPF;  A2RE90, TRUB_STRPG;  
Q48TB3, TRUB_STRPM;  Q97QJ3, TRUB_STRPN;  P0DD49, TRUB_STRPQ;  
Q8CWR2, TRUB_STRR6;  A3CMF2, TRUB_STRSV;  Q5LZV2, TRUB_STRT1;  
Q5M4G2, TRUB_STRT2;  Q30TG2, TRUB_SULDN;  A6Q784, TRUB_SULNB;  
Q980C3, TRUB_SULSO;  Q975L5, TRUB_SULTO;  Q67P83, TRUB_SYMTH;  
Q2LWU1, TRUB_SYNAS;  Q8KIY0, TRUB_SYNE7;  A0LHM2, TRUB_SYNFM;  
Q5N5A0, TRUB_SYNP6;  A5GN82, TRUB_SYNPW;  P59884, TRUB_SYNPX;  
Q0I7Z1, TRUB_SYNS3;  Q0AYI5, TRUB_SYNWW;  P74696, TRUB_SYNY3;  
Q9HIT4, TRUB_THEAC;  Q8CWM3, TRUB_THEEB;  Q47RU8, TRUB_THEFY;  
C5A255, TRUB_THEGJ;  Q5JJE8, TRUB_THEKO;  A6LLV6, TRUB_THEM4;  
Q9WZW0, TRUB_THEMA;  B6YSP4, TRUB_THEON;  A5IIS7, TRUB_THEP1;  
Q72GS9, TRUB_THET2;  Q5SLS6, TRUB_THET8;  Q8RA40, TRUB_THETN;  
Q97BU9, TRUB_THEVO;  Q31GK3, TRUB_THICR;  Q3SKX3, TRUB_THIDA;  
C4L8X2, TRUB_TOLAT;  Q73NP8, TRUB_TREDE;  O83859, TRUB_TREPA;  
B2S4C6, TRUB_TREPS;  Q112N2, TRUB_TRIEI;  Q820Z5, TRUB_TROW8;  
Q820Y5, TRUB_TROWT;  B1GZN9, TRUB_UNCTG;  B1AIZ3, TRUB_UREP2;  
Q9PQD7, TRUB_UREPA;  B5ZBG4, TRUB_UREU1;  A1WLI1, TRUB_VEREI;  
A5F928, TRUB_VIBC3;  A7MZI3, TRUB_VIBCB;  Q9KU78, TRUB_VIBCH;  
C3LSQ0, TRUB_VIBCM;  Q5E7L3, TRUB_VIBF1;  B5FA81, TRUB_VIBFM;  
Q87M04, TRUB_VIBPA;  B7VJH5, TRUB_VIBSL;  Q8DBV8, TRUB_VIBVU;  
Q7MI11, TRUB_VIBVY;  Q8D2X8, TRUB_WIGBR;  B3CM19, TRUB_WOLPP;  
Q7M9J1, TRUB_WOLSU;  Q8PJ57, TRUB_XANAC;  Q3BRP7, TRUB_XANC5;  
Q4UWA0, TRUB_XANC8;  B0RRB6, TRUB_XANCB;  Q8P7U9, TRUB_XANCP;  
Q2P0X3, TRUB_XANOM;  Q5GXV1, TRUB_XANOR;  Q9PGR1, TRUB_XYLFA;  
Q87EV2, TRUB_XYLFT;  A1JIX1, TRUB_YERE8;  O34273, TRUB_YEREN;  
A7FMS0, TRUB_YERP3;  Q1CC09, TRUB_YERPA;  Q8ZBC4, TRUB_YERPE;  
Q1CEL5, TRUB_YERPN;  A4TRI1, TRUB_YERPP;  Q66F58, TRUB_YERPS;  
Q5NQ30, TRUB_ZYMMO;  

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