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ENZYME entry: EC 5.4.99.45

Accepted Name
tRNA pseudouridine(38/39) synthase.
Alternative Name(s)
Pseudouridine synthase 3.
Reaction catalysed
tRNA uridine(38/39) <=> tRNA pseudouridine(38/39)
Comment(s)
  • The enzyme from Saccharomyces cerevisiae is active only toward uridine(38) and uridine(39), and shows no activity with uridine(40) (cf. EC 5.4.99.12).
  • In vitro the enzyme from mouse is active on uridine(39) and very slightly on uridine(38) (human tRNA(Leu)).
Cross-references
BRENDA5.4.99.45
EC2PDB5.4.99.45
ExplorEnz5.4.99.45
PRIAM enzyme-specific profiles5.4.99.45
KEGG Ligand Database for Enzyme Nomenclature5.4.99.45
IUBMB Enzyme Nomenclature5.4.99.45
IntEnz5.4.99.45
MEDLINEFind literature relating to 5.4.99.45
MetaCyc5.4.99.45
UniProtKB/Swiss-Prot
Q3SX07, PUS3_BOVIN;  Q9BZE2, PUS3_HUMAN;  Q9JI38, PUS3_MOUSE;  
P31115, PUS3_YEAST;  

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