ENZYME entry: EC 5.5.1.15

Accepted Name
Terpentedienyl-diphosphate synthase.
Alternative Name(s)
Clerodadienyl diphosphate synthase.
Terpentedienol diphosphate synthase.
Reaction catalysed
Geranylgeranyl diphosphate <=> terpentedienyl diphosphate
Cofactor(s)
Magnesium.
Comment(s)
  • Contains a DXDD motif, which is a characteristic of diterpene cylases whose reactions are initiated by protonation at the 14,15-double bond of geranylgeranyl diphosphate (GGDP).
  • The triggering proton is lost at the end of the cyclization reaction.
  • The product of the reaction, terpentedienyl diphosphate, is the substrate for EC 4.2.3.36 and is a precursor of the diterpenoid antibiotic terpentecin.
Cross-references
BRENDA5.5.1.15
EC2PDB5.5.1.15
ExplorEnz5.5.1.15
PRIAM enzyme-specific profiles5.5.1.15
KEGG Ligand Database for Enzyme Nomenclature5.5.1.15
IUBMB Enzyme Nomenclature5.5.1.15
IntEnz5.5.1.15
MEDLINEFind literature relating to 5.5.1.15
MetaCyc5.5.1.15
UniProtKB/Swiss-Prot
Q9AJE4, CYC1_KITGR

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.5.1.-
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