ENZYME entry: EC 5.5.1.16

Accepted Name
Halimadienyl-diphosphate synthase.
Alternative Name(s)
Tuberculosinol diphosphate synthase.
Reaction catalysed
Geranylgeranyl diphosphate <=> tuberculosinyl diphosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • Found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity.
  • The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).
Cross-references
BRENDA5.5.1.16
EC2PDB5.5.1.16
ExplorEnz5.5.1.16
PRIAM enzyme-specific profiles5.5.1.16
KEGG Ligand Database for Enzyme Nomenclature5.5.1.16
IUBMB Enzyme Nomenclature5.5.1.16
IntEnz5.5.1.16
MEDLINEFind literature relating to 5.5.1.16
MetaCyc5.5.1.16
UniProtKB/Swiss-Prot
O50406, DITCY_MYCTU

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