ID   5.6.2.1
DE   DNA topoisomerase.
AN   DNA topoisomerase I.
AN   nicking-closing enzyme.
AN   omega-protein.
AN   relaxing enzyme.
AN   swivelase.
AN   type I DNA topoisomerase.
AN   untwisting enzyme.
CA   ATP-independent breakage of single-stranded DNA, followed by passage and
CA   rejoining.
CC   -!- These enzymes bring about the conversion of one topological isomer of
CC       DNA into another, e.g., the relaxation of superhelical turns in DNA,
CC       the interconversion of simple and knotted rings of single-stranded
CC       DNA, and the intertwisting of single-stranded rings of complementary
CC       sequences, cf. EC 5.6.2.2.
CC   -!- Formerly EC 5.99.1.2.
DR   P13658, MBEA_ECOLX ;  P07112, MOBA2_ECOLX;  P30181, TOP1A_ARATH;
DR   Q9FJ79, TOP1B_ARATH;  Q7T6X9, TOP1E_MIMIV;  Q969P6, TOP1M_HUMAN;
DR   Q8R4U6, TOP1M_MOUSE;  A9Q1D5, TOP1M_PANTR;  Q6IM78, TOP1M_RAT  ;
DR   Q5UQB5, TOP1P_MIMIV;  Q9PHK2, TOP1P_XYLFA;  Q9YB01, TOP1_AERPE ;
DR   P34184, TOP1_ALKPO ;  O66893, TOP1_AQUAE ;  O28469, TOP1_ARCFU ;
DR   P40114, TOP1_BACAN ;  P39814, TOP1_BACSU ;  O51768, TOP1_BORBU ;
DR   P57371, TOP1_BUCAI ;  Q8K9P7, TOP1_BUCAP ;  O17966, TOP1_CAEEL ;
DR   Q9PLZ2, TOP1_CAMJE ;  A0A0L0P4F8, TOP1_CANAR ;  Q00313, TOP1_CANAX ;
DR   Q7YR26, TOP1_CHLAE ;  Q07050, TOP1_CRIGR ;  P93119, TOP1_DAUCA ;
DR   Q54RC3, TOP1_DICDI ;  P30189, TOP1_DROME ;  P06612, TOP1_ECOLI ;
DR   O34204, TOP1_FERIS ;  P43012, TOP1_HAEIN ;  Q9KA23, TOP1_HALH5 ;
DR   Q9ZMV7, TOP1_HELPJ ;  P55991, TOP1_HELPY ;  P11387, TOP1_HUMAN ;
DR   P46155, TOP1_KLEAE ;  Q9CG80, TOP1_LACLA ;  Q59046, TOP1_METJA ;
DR   O27661, TOP1_METTH ;  A0A7H0DN83, TOP1_MONPV ;  Q04750, TOP1_MOUSE ;
DR   P0A621, TOP1_MYCBO ;  Q9JN65, TOP1_MYCGA ;  P47368, TOP1_MYCGE ;
DR   O69548, TOP1_MYCLE ;  P78032, TOP1_MYCPN ;  A0R5D9, TOP1_MYCS2 ;
DR   A5U8X0, TOP1_MYCTA ;  P9WG48, TOP1_MYCTO ;  P9WG49, TOP1_MYCTU ;
DR   Q9CN30, TOP1_PASMU ;  Q9HZJ5, TOP1_PSEAE ;  Q9UYS8, TOP1_PYRAB ;
DR   O73954, TOP1_PYRFU ;  O58356, TOP1_PYRHO ;  Q9WUL0, TOP1_RAT   ;
DR   P16472, TOP1_RFVKA ;  Q1RIM1, TOP1_RICBR ;  Q92IH1, TOP1_RICCN ;
DR   Q4UM42, TOP1_RICFE ;  Q9ZDK2, TOP1_RICPR ;  Q68X45, TOP1_RICTY ;
DR   P0A2I2, TOP1_SALTI ;  P0A2I1, TOP1_SALTY ;  P07799, TOP1_SCHPO ;
DR   Q2FHI8, TOP1_STAA3 ;  Q2FZ32, TOP1_STAA8 ;  Q2YXL8, TOP1_STAAB ;
DR   Q5HGI2, TOP1_STAAC ;  Q99UM1, TOP1_STAAM ;  Q7A5Y5, TOP1_STAAN ;
DR   Q6GHI5, TOP1_STAAR ;  Q6G9W3, TOP1_STAAS ;  Q06AK7, TOP1_STAAU ;
DR   Q8NWZ9, TOP1_STAAW ;  Q5HPU2, TOP1_STAEQ ;  Q8CSU3, TOP1_STAES ;
DR   Q4L5V2, TOP1_STAHJ ;  Q49X35, TOP1_STAS1 ;  Q9X909, TOP1_STRCO ;
DR   P34185, TOP1_SYNE7 ;  P73810, TOP1_SYNY3 ;  Q9HM08, TOP1_THEAC ;
DR   P46799, TOP1_THEMA ;  O83409, TOP1_TREPA ;  P41511, TOP1_USTMA ;
DR   Q76ZS7, TOP1_VACCA ;  P68697, TOP1_VACCC ;  P68698, TOP1_VACCW ;
DR   P32989, TOP1_VAR67 ;  Q9KRB2, TOP1_VIBCH ;  P41512, TOP1_XENLA ;
DR   Q9PEV8, TOP1_XYLFA ;  Q87AQ6, TOP1_XYLFT ;  P04786, TOP1_YEAST ;
DR   Q9X3X7, TOP1_ZYMMO ;  Q9LVP1, TOP3A_ARATH;  Q9NG98, TOP3A_DROME;
DR   Q13472, TOP3A_HUMAN;  O70157, TOP3A_MOUSE;  C7J0A2, TOP3A_ORYSJ;
DR   F4ISQ7, TOP3B_ARATH;  O96651, TOP3B_DROME;  O95985, TOP3B_HUMAN;
DR   Q9Z321, TOP3B_MOUSE;  Q0J0S6, TOP3B_ORYSJ;  A0R979, TOP3_BACAH ;
DR   Q81Z97, TOP3_BACAN ;  Q73E74, TOP3_BACC1 ;  Q81IH1, TOP3_BACCR ;
DR   Q63GK5, TOP3_BACCZ ;  Q6HP19, TOP3_BACHK ;  Q65N90, TOP3_BACLD ;
DR   P96583, TOP3_BACSU ;  O61660, TOP3_CAEEL ;  A0A0L0P6P7, TOP3_CANAR ;
DR   Q8T2T7, TOP3_DICDI ;  P14294, TOP3_ECOLI ;  P43704, TOP3_HAEIN ;
DR   Q9CP53, TOP3_PASMU ;  Q8Z6F5, TOP3_SALTI ;  P40687, TOP3_SALTY ;
DR   O60126, TOP3_SCHPO ;  Q5WAX6, TOP3_SHOC1 ;  Q2FEN5, TOP3_STAA3 ;
DR   Q2FW03, TOP3_STAA8 ;  P0C2W6, TOP3_STAAB ;  Q5HDV4, TOP3_STAAC ;
DR   Q99S17, TOP3_STAAM ;  Q7A455, TOP3_STAAN ;  Q6GEH9, TOP3_STAAR ;
DR   Q6G767, TOP3_STAAS ;  Q7A075, TOP3_STAAW ;  Q5HLZ4, TOP3_STAEQ ;
DR   Q8CRF7, TOP3_STAES ;  Q4L8B8, TOP3_STAHJ ;  Q49ZH2, TOP3_STAS1 ;
DR   Q9KQF5, TOP3_VIBCH ;  P13099, TOP3_YEAST ;  P14565, TRAI1_ECOLI;
DR   P22706, TRAI2_ECOLX;
//