ENZYME entry: EC 5.99.1.2

Accepted Name
DNA topoisomerase.
Alternative Name(s)
DNA topoisomerase I.
Nicking-closing enzyme.
Omega-protein.
Relaxing enzyme.
Swivelase.
Type I DNA topoisomerase.
Untwisting enzyme.
Reaction catalysed
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining
Comment(s)
Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
Cross-references
PROSITEPDOC00159 ; PDOC00333
BRENDA5.99.1.2
EC2PDB5.99.1.2
ExplorEnz5.99.1.2
PRIAM enzyme-specific profiles5.99.1.2
KEGG Ligand Database for Enzyme Nomenclature5.99.1.2
IUBMB Enzyme Nomenclature5.99.1.2
IntEnz5.99.1.2
MEDLINEFind literature relating to 5.99.1.2
MetaCyc5.99.1.2
UniProtKB/Swiss-Prot
P13658, MBEA_ECOLX;  P07112, MOBA2_ECOLX;  Q7T6X9, TOP1E_MIMIV;  
Q969P6, TOP1M_HUMAN;  Q8R4U6, TOP1M_MOUSE;  A9Q1D5, TOP1M_PANTR;  
Q6IM78, TOP1M_RAT;  Q5UQB5, TOP1P_MIMIV;  Q9PHK2, TOP1P_XYLFA;  
Q9YB01, TOP1_AERPE;  O66893, TOP1_AQUAE;  P30181, TOP1_ARATH;  
O28469, TOP1_ARCFU;  P40114, TOP1_BACAN;  Q9KA23, TOP1_BACHD;  
P34184, TOP1_BACPE;  P39814, TOP1_BACSU;  O51768, TOP1_BORBU;  
P57371, TOP1_BUCAI;  Q8K9P7, TOP1_BUCAP;  O17966, TOP1_CAEEL;  
Q9PLZ2, TOP1_CAMJE;  Q00313, TOP1_CANAX;  Q7YR26, TOP1_CHLAE;  
Q07050, TOP1_CRIGR;  P93119, TOP1_DAUCA;  Q54RC3, TOP1_DICDI;  
P30189, TOP1_DROME;  P06612, TOP1_ECOLI;  P46155, TOP1_ENTAE;  
O34204, TOP1_FERIS;  P43012, TOP1_HAEIN;  Q9ZMV7, TOP1_HELPJ;  
P55991, TOP1_HELPY;  P11387, TOP1_HUMAN;  Q9CG80, TOP1_LACLA;  
Q59046, TOP1_METJA;  O27661, TOP1_METTH;  Q04750, TOP1_MOUSE;  
P0A621, TOP1_MYCBO;  Q9JN65, TOP1_MYCGA;  P47368, TOP1_MYCGE;  
O69548, TOP1_MYCLE;  P78032, TOP1_MYCPN;  P9WG48, TOP1_MYCTO;  
P9WG49, TOP1_MYCTU;  Q9CN30, TOP1_PASMU;  Q9HZJ5, TOP1_PSEAE;  
Q9UYS8, TOP1_PYRAB;  O73954, TOP1_PYRFU;  O58356, TOP1_PYRHO;  
Q9WUL0, TOP1_RAT;  P16472, TOP1_RFVKA;  Q1RIM1, TOP1_RICBR;  
Q92IH1, TOP1_RICCN;  Q4UM42, TOP1_RICFE;  Q9ZDK2, TOP1_RICPR;  
Q68X45, TOP1_RICTY;  P0A2I2, TOP1_SALTI;  P0A2I1, TOP1_SALTY;  
P07799, TOP1_SCHPO;  Q2FHI8, TOP1_STAA3;  Q2FZ32, TOP1_STAA8;  
Q2YXL8, TOP1_STAAB;  Q5HGI2, TOP1_STAAC;  Q99UM1, TOP1_STAAM;  
Q7A5Y5, TOP1_STAAN;  Q6GHI5, TOP1_STAAR;  Q6G9W3, TOP1_STAAS;  
Q06AK7, TOP1_STAAU;  Q8NWZ9, TOP1_STAAW;  Q5HPU2, TOP1_STAEQ;  
Q8CSU3, TOP1_STAES;  Q4L5V2, TOP1_STAHJ;  Q49X35, TOP1_STAS1;  
Q9X909, TOP1_STRCO;  P34185, TOP1_SYNE7;  P73810, TOP1_SYNY3;  
Q9HM08, TOP1_THEAC;  P46799, TOP1_THEMA;  O83409, TOP1_TREPA;  
P41511, TOP1_USTMA;  Q76ZS7, TOP1_VACCA;  P68697, TOP1_VACCC;  
P68698, TOP1_VACCW;  P32989, TOP1_VAR67;  Q9KRB2, TOP1_VIBCH;  
P41512, TOP1_XENLA;  Q9PEV8, TOP1_XYLFA;  Q87AQ6, TOP1_XYLFT;  
P04786, TOP1_YEAST;  Q9X3X7, TOP1_ZYMMO;  Q9LVP1, TOP3A_ARATH;  
Q9NG98, TOP3A_DROME;  Q13472, TOP3A_HUMAN;  O70157, TOP3A_MOUSE;  
C7J0A2, TOP3A_ORYSJ;  F4ISQ7, TOP3B_ARATH;  O96651, TOP3B_DROME;  
O95985, TOP3B_HUMAN;  Q9Z321, TOP3B_MOUSE;  Q0J0S6, TOP3B_ORYSJ;  
A0R979, TOP3_BACAH;  Q81Z97, TOP3_BACAN;  Q73E74, TOP3_BACC1;  
Q81IH1, TOP3_BACCR;  Q63GK5, TOP3_BACCZ;  Q6HP19, TOP3_BACHK;  
Q65N90, TOP3_BACLD;  Q5WAX6, TOP3_BACSK;  P96583, TOP3_BACSU;  
O61660, TOP3_CAEEL;  Q8T2T7, TOP3_DICDI;  P14294, TOP3_ECOLI;  
P43704, TOP3_HAEIN;  Q9CP53, TOP3_PASMU;  Q8Z6F5, TOP3_SALTI;  
P40687, TOP3_SALTY;  O60126, TOP3_SCHPO;  Q2FEN5, TOP3_STAA3;  
Q2FW03, TOP3_STAA8;  P0C2W6, TOP3_STAAB;  Q5HDV4, TOP3_STAAC;  
Q99S17, TOP3_STAAM;  Q7A455, TOP3_STAAN;  Q6GEH9, TOP3_STAAR;  
Q6G767, TOP3_STAAS;  Q7A075, TOP3_STAAW;  Q5HLZ4, TOP3_STAEQ;  
Q8CRF7, TOP3_STAES;  Q4L8B8, TOP3_STAHJ;  Q49ZH2, TOP3_STAS1;  
Q9KQF5, TOP3_VIBCH;  P13099, TOP3_YEAST;  P14565, TRAI1_ECOLI;  
P22706, TRAI2_ECOLX;  

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.99.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.99.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.-.-.-