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ENZYME entry: EC 5.99.1.3

Accepted Name
DNA topoisomerase (ATP-hydrolyzing).
Alternative Name(s)
DNA gyrase.
DNA topoisomerase II.
Type II DNA topoisomerase.
Reaction catalysed
ATP-dependent breakage, passage and rejoining of double-stranded DNA
Comment(s)
  • Can introduce negative superhelical turns into double-stranded circular DNA.
  • One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
Cross-references
PROSITEPDOC00160
BRENDA5.99.1.3
EC2PDB5.99.1.3
ExplorEnz5.99.1.3
PRIAM enzyme-specific profiles5.99.1.3
KEGG Ligand Database for Enzyme Nomenclature5.99.1.3
IUBMB Enzyme Nomenclature5.99.1.3
IntEnz5.99.1.3
MEDLINEFind literature relating to 5.99.1.3
MetaCyc5.99.1.3
UniProtKB/Swiss-Prot
P48369, GYRA_AERSA;  D5ECW5, GYRA_AMICL;  Q9CAF6, GYRA_ARATH;  
O50628, GYRA_BACHD;  P05653, GYRA_BACSU;  O51396, GYRA_BORBU;  
B2S0D7, GYRA_BORHD;  C0R046, GYRA_BRAHW;  P57277, GYRA_BUCAI;  
Q8K9W2, GYRA_BUCAP;  Q89AS3, GYRA_BUCBP;  P47235, GYRA_CAMFE;  
Q03470, GYRA_CAMJE;  Q9PKK4, GYRA_CHLMU;  Q9Z8R4, GYRA_CHLPN;  
O84192, GYRA_CHLTR;  P94605, GYRA_CLOAB;  D8K235, GYRA_DEHLB;  
C1CVF4, GYRA_DEIDV;  P0AES4, GYRA_ECOLI;  P35810, GYRA_FIBSS;  
Q0BST5, GYRA_GRABC;  P43700, GYRA_HAEIN;  P21557, GYRA_HALL2;  
Q18GY3, GYRA_HALWD;  Q9ZLD9, GYRA_HELPJ;  P48370, GYRA_HELPY;  
P14829, GYRA_KLEOX;  C5CHA8, GYRA_KOSOT;  Q1MQ89, GYRA_LAWIP;  
B0S912, GYRA_LEPBA;  C5C7X9, GYRA_MICLC;  B3PN30, GYRA_MYCA5;  
A0A0G2Q9F8, GYRA_MYCBP;  Q49166, GYRA_MYCFV;  P47719, GYRA_MYCGA;  
P47250, GYRA_MYCGE;  Q49467, GYRA_MYCGO;  Q49608, GYRA_MYCKA;  
Q57532, GYRA_MYCLE;  O33149, GYRA_MYCMA;  P22446, GYRA_MYCPN;  
P48354, GYRA_MYCS2;  Q59556, GYRA_MYCSM;  P9WG46, GYRA_MYCTO;  
P9WG47, GYRA_MYCTU;  P72065, GYRA_MYCXE;  P48371, GYRA_NEIGO;  
Q5YLB5, GYRA_NICBE;  A1SCM2, GYRA_NOCSJ;  Q7XZF7, GYRA_ORYSJ;  
P41513, GYRA_PECCA;  P48372, GYRA_PSEAE;  Q1RID9, GYRA_RICBR;  
Q92IZ6, GYRA_RICCN;  Q4UKM1, GYRA_RICFE;  P41080, GYRA_RICPR;  
Q68XG2, GYRA_RICTY;  P37411, GYRA_SALTY;  P0AES5, GYRA_SHIFL;  
P34030, GYRA_SPICI;  Q2FKQ0, GYRA_STAA3;  Q2G2Q0, GYRA_STAA8;  
Q5HJZ0, GYRA_STAAC;  Q932M0, GYRA_STAAM;  Q99XG5, GYRA_STAAN;  
Q6GKT9, GYRA_STAAR;  Q6GD84, GYRA_STAAS;  P20831, GYRA_STAAU;  
Q8NKW8, GYRA_STAAW;  P0C0Q9, GYRA_STAEP;  Q5HK04, GYRA_STAEQ;  
P0C0R0, GYRA_STAES;  P35885, GYRA_STRCO;  P50071, GYRA_STRNV;  
Q9L7Q5, GYRA_STRP1;  P0DG02, GYRA_STRP3;  Q5XC58, GYRA_STRP6;  
Q8P116, GYRA_STRP8;  P72524, GYRA_STRPN;  P0DG03, GYRA_STRPQ;  
Q8DPM2, GYRA_STRR6;  Q55738, GYRA_SYNY3;  O33926, GYRA_THEMA;  
Q5SIL4, GYRA_THET8;  O83051, GYRA_TREPA;  Q9PR63, GYRA_UREPA;  
Q44088, GYRB1_ACILW;  Q44272, GYRB2_ACILW;  Q94BZ7, GYRBM_ARATH;  
Q9SS38, GYRBP_ARATH;  P50074, GYRBR_STRNV;  P50075, GYRBS_STRNV;  
Q43907, GYRB_ACIBA;  Q44273, GYRB_ACIBZ;  Q43947, GYRB_ACICA;  
Q44271, GYRB_ACIG6;  Q44274, GYRB_ACIGI;  Q44065, GYRB_ACIHA;  
Q44081, GYRB_ACIJO;  Q44080, GYRB_ACIJU;  Q44270, GYRB_ACIPI;  
Q44278, GYRB_ACIS7;  Q44275, GYRB_ACIS8;  Q44276, GYRB_ACIS9;  
Q44277, GYRB_ACIVR;  O29720, GYRB_ARCFU;  Q9X3Y6, GYRB_BACAN;  
Q9X3Y3, GYRB_BACCE;  O50627, GYRB_BACHD;  Q9X3Y5, GYRB_BACMY;  
P05652, GYRB_BACSU;  P33769, GYRB_BORBU;  Q9ZFK1, GYRB_BORHE;  
P57126, GYRB_BUCAI;  P29435, GYRB_BUCAP;  Q89B37, GYRB_BUCBP;  
O87667, GYRB_CAMJE;  B8GXQ0, GYRB_CAUCN;  P0CAX1, GYRB_CAUCR;  
Q9FAX2, GYRB_CHIJA;  Q9PKK3, GYRB_CHLMU;  Q9Z8R3, GYRB_CHLPN;  
O84193, GYRB_CHLTR;  P94604, GYRB_CLOAB;  Q9LCK0, GYRB_CYTAU;  
Q9LCK1, GYRB_CYTHU;  P0AES7, GYRB_ECO57;  P0AES6, GYRB_ECOLI;  
Q9FAX1, GYRB_EISEL;  Q839Z1, GYRB_ENTFA;  P43701, GYRB_HAEIN;  
P21558, GYRB_HALL2;  D4GZ01, GYRB_HALVD;  Q9ZLX3, GYRB_HELPJ;  
P55992, GYRB_HELPY;  C5C7X8, GYRB_MICLC;  Q9ZAQ6, GYRB_MYCAT;  
A0A0G2Q9D6, GYRB_MYCBP;  P47720, GYRB_MYCGA;  P47249, GYRB_MYCGE;  
P43053, GYRB_MYCHP;  Q59533, GYRB_MYCLE;  Q9L7L3, GYRB_MYCPA;  
P22447, GYRB_MYCPN;  A0QNE0, GYRB_MYCS2;  P0C559, GYRB_MYCSM;  
A5TY73, GYRB_MYCTA;  P9WG44, GYRB_MYCTO;  P9WG45, GYRB_MYCTU;  
O33367, GYRB_MYXXA;  P22118, GYRB_NEIGO;  Q5YLB4, GYRB_NICBE;  
Q5NBJ3, GYRB_ORYSJ;  P22840, GYRB_PROMI;  Q9I7C2, GYRB_PSEAE;  
P13364, GYRB_PSEPU;  P31860, GYRB_RHOCA;  Q1RHT8, GYRB_RICBR;  
Q92H87, GYRB_RICCN;  Q4UKX5, GYRB_RICFE;  Q9ZCX2, GYRB_RICPR;  
Q68WF6, GYRB_RICTY;  P0A2I4, GYRB_SALTI;  P0A2I3, GYRB_SALTY;  
P0AES8, GYRB_SHIFL;  P34031, GYRB_SPICI;  Q2FKQ1, GYRB_STAA3;  
Q5HJZ1, GYRB_STAAC;  P66936, GYRB_STAAM;  P66937, GYRB_STAAN;  
Q6GKU0, GYRB_STAAR;  Q6GD85, GYRB_STAAS;  P0A0K8, GYRB_STAAU;  
P0A0K7, GYRB_STAAW;  Q5HK03, GYRB_STAEQ;  Q8CQK4, GYRB_STAES;  
P35886, GYRB_STRCO;  Q9A0L0, GYRB_STRP1;  P0DG04, GYRB_STRP3;  
Q5XD05, GYRB_STRP6;  Q8P1M4, GYRB_STRP8;  P0A4L9, GYRB_STRPN;  
P0DG05, GYRB_STRPQ;  P0A4M0, GYRB_STRR6;  P77966, GYRB_SYNY3;  
P77993, GYRB_THEMA;  Q5SHZ4, GYRB_THET8;  O87545, GYRB_TREDE;  
O08399, GYRB_TREPA;  Q9KVX3, GYRB_VIBCH;  O51859, GYRB_VIBPA;  
Q45066, PARC_BACSU;  O51066, PARC_BORBU;  O54478, PARC_CAUCR;  
O68891, PARC_CROSK;  P0AFI3, PARC_ECO57;  P0AFI2, PARC_ECOLI;  
P43702, PARC_HAEIN;  P47446, PARC_MYCGE;  P75352, PARC_MYCPN;  
P48374, PARC_NEIGO;  Q9HUK1, PARC_PSEAE;  Q59749, PARC_RHIME;  
Q1RGX8, PARC_RICBR;  Q92JH0, PARC_RICCN;  Q4UNA0, PARC_RICFE;  
Q9ZE79, PARC_RICPR;  Q68XU1, PARC_RICTY;  P26973, PARC_SALTY;  
P0AFI4, PARC_SHIFL;  Q2FYS4, PARC_STAA8;  Q5HG64, PARC_STAAC;  
Q931S2, PARC_STAAM;  Q93KF4, PARC_STAAN;  Q6GH50, PARC_STAAR;  
Q6G9K4, PARC_STAAS;  P0C1U9, PARC_STAAU;  Q8NWU8, PARC_STAAW;  
Q5HPI5, PARC_STAEQ;  Q8CSN8, PARC_STAES;  Q9L7Q4, PARC_STRP1;  
P0DG06, PARC_STRP3;  Q5XCJ9, PARC_STRP6;  Q8P1B3, PARC_STRP8;  
P72525, PARC_STRPN;  P0DG07, PARC_STRPQ;  P73077, PARC_SYNY3;  
Q59192, PARE_BACSU;  P94281, PARE_BARBK;  Q59189, PARE_BORBU;  
O54479, PARE_CAUCR;  P20083, PARE_ECOLI;  H7C794, PARE_ENTFA;  
A0A0J9WZF0, PARE_FRATH;  P43703, PARE_HAEIN;  P50028, PARE_MYCCT;  
Q59526, PARE_MYCGA;  P47445, PARE_MYCGE;  P78016, PARE_MYCPN;  
Q9HUJ8, PARE_PSEAE;  Q1RK03, PARE_RICBR;  Q92IW1, PARE_RICCN;  
Q4UKT4, PARE_RICFE;  Q9ZDU7, PARE_RICPR;  Q68XE1, PARE_RICTY;  
P0A2I6, PARE_SALTI;  P0A2I5, PARE_SALTY;  Q2FYS5, PARE_STAA8;  
Q5HG65, PARE_STAAC;  P66938, PARE_STAAM;  P66939, PARE_STAAN;  
Q6GH51, PARE_STAAR;  Q6G9K5, PARE_STAAS;  P0C1S7, PARE_STAAU;  
P0A0K9, PARE_STAAW;  Q5HPI6, PARE_STAEQ;  Q8CSN9, PARE_STAES;  
Q59961, PARE_STRPN;  Q9YCB6, RGYR1_AERPE;  O67037, RGYR1_AQUAE;  
Q97ZZ8, RGYR1_SULSO;  Q971T7, RGYR1_SULTO;  Q9YC75, RGYR2_AERPE;  
O67226, RGYR2_AQUAE;  Q97ZF5, RGYR2_SULSO;  Q975P6, RGYR2_SULTO;  
O29238, RGYR_ARCFU;  Q8R979, RGYR_CALS4;  Q58907, RGYR_METJA;  
Q9UZ86, RGYR_PYRAB;  Q8ZXT5, RGYR_PYRAE;  P95479, RGYR_PYRFU;  
O58530, RGYR_PYRHO;  Q08582, RGYR_SULAC;  P74759, RGYR_SULSH;  
Q6F598, RGYR_THEKO;  O51934, RGYR_THEMA;  Q9M4A2, SPO11_ARATH;  
Q9Y5K1, SPO11_HUMAN;  Q9WTK8, SPO11_MOUSE;  P23179, SPO11_YEAST;  
Q9M4A1, SPO12_ARATH;  O42130, TOP2A_CHICK;  P41515, TOP2A_CRIGR;  
P11388, TOP2A_HUMAN;  Q01320, TOP2A_MOUSE;  O46374, TOP2A_PIG;  
P41516, TOP2A_RAT;  O42131, TOP2B_CHICK;  Q64399, TOP2B_CRILO;  
Q02880, TOP2B_HUMAN;  Q64511, TOP2B_MOUSE;  P34534, TOP2M_CAEEL;  
P90520, TOP2M_DICDI;  P30182, TOP2_ARATH;  Q00942, TOP2_ASFB7;  
P0C9C2, TOP2_ASFK5;  P34203, TOP2_ASFM2;  P0C9C0, TOP2_ASFP4;  
P0C9C1, TOP2_ASFWA;  O16140, TOP2_BOMMO;  Q23670, TOP2_CAEEL;  
P87078, TOP2_CANAX;  O93794, TOP2_CANGA;  P27570, TOP2_CRIFA;  
Q55BP5, TOP2_DICDI;  P15348, TOP2_DROME;  Q196X4, TOP2_IIV3;  
Q9QSK1, TOP2_IIV6;  O61078, TOP2_LEICH;  Q5UQE6, TOP2_MIMIV;  
O24308, TOP2_PEA;  Q9Y8G8, TOP2_PENCH;  Q01879, TOP2_PICGU;  
P41001, TOP2_PLAFK;  P08096, TOP2_SCHPO;  P12531, TOP2_TRYBB;  
P30190, TOP2_TRYCR;  P06786, TOP2_YEAST;  O67108, TOP4A_AQUAE;  
O67137, TOP4B_AQUAE;  P07065, TOP5_BPT4;  Q9YE67, TOP6A_AERPE;  
Q9LZ03, TOP6A_ARATH;  O29322, TOP6A_ARCFU;  Q5V4R4, TOP6A_HALMA;  
B0R4D2, TOP6A_HALS3;  Q9HR32, TOP6A_HALSA;  A2BLE8, TOP6A_HYPBU;  
Q8TQF8, TOP6A_METAC;  Q468I6, TOP6A_METBF;  Q57815, TOP6A_METJA;  
Q8PUB7, TOP6A_METMA;  O27089, TOP6A_METTH;  Q3IPW7, TOP6A_NATPD;  
A2XFC1, TOP6A_ORYSI;  Q0DSV9, TOP6A_ORYSJ;  Q9V134, TOP6A_PYRAB;  
Q8U0K9, TOP6A_PYRFU;  O59209, TOP6A_PYRHO;  O05208, TOP6A_SULSH;  
Q971T1, TOP6A_SULTO;  Q5JH82, TOP6A_THEKO;  Q9YE64, TOP6B_AERPE;  
Q9C5V6, TOP6B_ARATH;  O29605, TOP6B_ARCFU;  Q5V4R5, TOP6B_HALMA;  
B0R4D3, TOP6B_HALS3;  Q9HR31, TOP6B_HALSA;  Q8TQF7, TOP6B_METAC;  
Q468I5, TOP6B_METBF;  Q12WQ0, TOP6B_METBU;  Q58434, TOP6B_METJA;  
Q8PUB8, TOP6B_METMA;  A4YHK7, TOP6B_METS5;  O27088, TOP6B_METTH;  
Q3IPW6, TOP6B_NATPD;  B8BDQ4, TOP6B_ORYSI;  Q6H442, TOP6B_ORYSJ;  
Q9V135, TOP6B_PYRAB;  Q8ZVM0, TOP6B_PYRAE;  Q8U0K8, TOP6B_PYRFU;  
O74020, TOP6B_PYRHO;  C3N5B3, TOP6B_SULIA;  C4KGX9, TOP6B_SULIK;  
C3MPN7, TOP6B_SULIL;  C3MYN1, TOP6B_SULIM;  C3NHT6, TOP6B_SULIN;  
C3NDW7, TOP6B_SULIY;  O05207, TOP6B_SULSH;  Q97ZF0, TOP6B_SULSO;  
Q971T2, TOP6B_SULTO;  C5A6R5, TOP6B_THEGJ;  Q5JH81, TOP6B_THEKO;  
B6YVS9, TOP6B_THEON;  C6A3G4, TOP6B_THESM;  P09176, TOPL_BPT4;  
A0QPN1, TOPOM_MYCS2;  A0QPN2, TOPON_MYCS2;  P23992, TOPS_BPT4;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.99.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.99.-.-
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