ID   5.99.1.3
DE   DNA topoisomerase (ATP-hydrolyzing).
AN   DNA gyrase.
AN   DNA topoisomerase II.
AN   Type II DNA topoisomerase.
CA   ATP-dependent breakage, passage and rejoining of double-stranded DNA.
CC   -!- Can introduce negative superhelical turns into double-stranded
CC       circular DNA.
CC   -!- One unit has nicking-closing activity, and another catalyzes super-
CC       twisting and hydrolysis of ATP (cf. EC 5.99.1.2).
PR   PROSITE; PDOC00160;
DR   P48369, GYRA_AERSA ;  D5ECW5, GYRA_AMICL ;  O67108, GYRA_AQUAE ;
DR   Q9CAF6, GYRA_ARATH ;  O50628, GYRA_BACHD ;  P05653, GYRA_BACSU ;
DR   O51396, GYRA_BORBU ;  B2S0D7, GYRA_BORHD ;  C0R046, GYRA_BRAHW ;
DR   P57277, GYRA_BUCAI ;  Q8K9W2, GYRA_BUCAP ;  Q89AS3, GYRA_BUCBP ;
DR   P47235, GYRA_CAMFE ;  Q03470, GYRA_CAMJE ;  Q9PKK4, GYRA_CHLMU ;
DR   Q9Z8R4, GYRA_CHLPN ;  O84192, GYRA_CHLTR ;  P94605, GYRA_CLOAB ;
DR   D8K235, GYRA_DEHLB ;  C1CVF4, GYRA_DEIDV ;  P0AES4, GYRA_ECOLI ;
DR   P41513, GYRA_ERWCA ;  P35810, GYRA_FIBSS ;  Q0BST5, GYRA_GRABC ;
DR   P43700, GYRA_HAEIN ;  P21557, GYRA_HALL2 ;  Q18GY3, GYRA_HALWD ;
DR   Q9ZLD9, GYRA_HELPJ ;  P48370, GYRA_HELPY ;  P14829, GYRA_KLEOX ;
DR   C5CHA8, GYRA_KOSOT ;  Q1MQ89, GYRA_LAWIP ;  B0S912, GYRA_LEPBA ;
DR   B3PN30, GYRA_MYCA5 ;  Q49166, GYRA_MYCFV ;  P47719, GYRA_MYCGA ;
DR   P47250, GYRA_MYCGE ;  Q49467, GYRA_MYCGO ;  Q49608, GYRA_MYCKA ;
DR   Q57532, GYRA_MYCLE ;  O33149, GYRA_MYCMA ;  P22446, GYRA_MYCPN ;
DR   P48354, GYRA_MYCS2 ;  Q07702, GYRA_MYCTU ;  P72065, GYRA_MYCXE ;
DR   P48371, GYRA_NEIGO ;  Q5YLB5, GYRA_NICBE ;  A1SCM2, GYRA_NOCSJ ;
DR   Q7XZF7, GYRA_ORYSJ ;  P48372, GYRA_PSEAE ;  Q1RID9, GYRA_RICBR ;
DR   Q92IZ6, GYRA_RICCN ;  Q4UKM1, GYRA_RICFE ;  P41080, GYRA_RICPR ;
DR   Q68XG2, GYRA_RICTY ;  P37411, GYRA_SALTY ;  P0AES5, GYRA_SHIFL ;
DR   P34030, GYRA_SPICI ;  Q2FKQ0, GYRA_STAA3 ;  Q2G2Q0, GYRA_STAA8 ;
DR   Q5HJZ0, GYRA_STAAC ;  Q932M0, GYRA_STAAM ;  Q99XG5, GYRA_STAAN ;
DR   Q6GKT9, GYRA_STAAR ;  Q6GD84, GYRA_STAAS ;  P20831, GYRA_STAAU ;
DR   Q8NKW8, GYRA_STAAW ;  P0C0Q9, GYRA_STAEP ;  Q5HK04, GYRA_STAEQ ;
DR   P0C0R0, GYRA_STAES ;  P35885, GYRA_STRCO ;  Q9L7Q5, GYRA_STRP1 ;
DR   P0DG02, GYRA_STRP3 ;  Q5XC58, GYRA_STRP6 ;  Q8P116, GYRA_STRP8 ;
DR   P72524, GYRA_STRPN ;  P0DG03, GYRA_STRPQ ;  Q8DPM2, GYRA_STRR6 ;
DR   P50071, GYRA_STRSH ;  Q55738, GYRA_SYNY3 ;  O33926, GYRA_THEMA ;
DR   O83051, GYRA_TREPA ;  Q9PR63, GYRA_UREPA ;  Q44088, GYRB1_ACILW;
DR   Q44272, GYRB2_ACILW;  Q94BZ7, GYRBM_ARATH;  Q9SS38, GYRBP_ARATH;
DR   P50074, GYRBR_STRSH;  P50075, GYRBS_STRSH;  Q43907, GYRB_ACIBA ;
DR   Q43947, GYRB_ACICA ;  Q44270, GYRB_ACIG3 ;  Q44271, GYRB_ACIG6 ;
DR   Q44273, GYRB_ACIGA ;  Q44274, GYRB_ACIGB ;  Q44065, GYRB_ACIHA ;
DR   Q44081, GYRB_ACIJO ;  Q44080, GYRB_ACIJU ;  Q44277, GYRB_ACIS6 ;
DR   Q44278, GYRB_ACIS7 ;  Q44275, GYRB_ACIS8 ;  Q44276, GYRB_ACIS9 ;
DR   O67137, GYRB_AQUAE ;  O29720, GYRB_ARCFU ;  Q9X3Y6, GYRB_BACAN ;
DR   Q9X3Y3, GYRB_BACCE ;  O50627, GYRB_BACHD ;  Q9X3Y5, GYRB_BACMY ;
DR   P05652, GYRB_BACSU ;  P94281, GYRB_BARBK ;  P33769, GYRB_BORBU ;
DR   Q9ZFK1, GYRB_BORHE ;  P57126, GYRB_BUCAI ;  P29435, GYRB_BUCAP ;
DR   Q89B37, GYRB_BUCBP ;  O87667, GYRB_CAMJE ;  B8GXQ0, GYRB_CAUCN ;
DR   P0CAX1, GYRB_CAUCR ;  Q9FAX2, GYRB_CHIJA ;  Q9PKK3, GYRB_CHLMU ;
DR   Q9Z8R3, GYRB_CHLPN ;  O84193, GYRB_CHLTR ;  P94604, GYRB_CLOAB ;
DR   Q9LCK0, GYRB_CYTAU ;  Q9LCK1, GYRB_CYTHU ;  P0AES7, GYRB_ECO57 ;
DR   P0AES6, GYRB_ECOLI ;  Q9FAX1, GYRB_FLEEL ;  P43701, GYRB_HAEIN ;
DR   P21558, GYRB_HALL2 ;  D4GZ01, GYRB_HALVD ;  Q9ZLX3, GYRB_HELPJ ;
DR   P55992, GYRB_HELPY ;  Q9ZAQ6, GYRB_MYCAT ;  P50028, GYRB_MYCCT ;
DR   P47720, GYRB_MYCGA ;  P47249, GYRB_MYCGE ;  P43053, GYRB_MYCHP ;
DR   Q59533, GYRB_MYCLE ;  Q9L7L3, GYRB_MYCPA ;  P22447, GYRB_MYCPN ;
DR   A0QNE0, GYRB_MYCS2 ;  P0C559, GYRB_MYCSM ;  A5TY73, GYRB_MYCTA ;
DR   P0C5C5, GYRB_MYCTU ;  O33367, GYRB_MYXXA ;  P22118, GYRB_NEIGO ;
DR   Q5YLB4, GYRB_NICBE ;  Q5NBJ3, GYRB_ORYSJ ;  P22840, GYRB_PROMI ;
DR   Q9I7C2, GYRB_PSEAE ;  P13364, GYRB_PSEPU ;  P31860, GYRB_RHOCA ;
DR   Q1RHT8, GYRB_RICBR ;  Q92H87, GYRB_RICCN ;  Q4UKX5, GYRB_RICFE ;
DR   Q9ZCX2, GYRB_RICPR ;  Q68WF6, GYRB_RICTY ;  P0A2I4, GYRB_SALTI ;
DR   P0A2I3, GYRB_SALTY ;  P0AES8, GYRB_SHIFL ;  P34031, GYRB_SPICI ;
DR   Q2FKQ1, GYRB_STAA3 ;  Q5HJZ1, GYRB_STAAC ;  P66936, GYRB_STAAM ;
DR   P66937, GYRB_STAAN ;  Q6GKU0, GYRB_STAAR ;  Q6GD85, GYRB_STAAS ;
DR   P0A0K8, GYRB_STAAU ;  P0A0K7, GYRB_STAAW ;  Q5HK03, GYRB_STAEQ ;
DR   Q8CQK4, GYRB_STAES ;  P35886, GYRB_STRCO ;  Q9A0L0, GYRB_STRP1 ;
DR   P0DG04, GYRB_STRP3 ;  Q5XD05, GYRB_STRP6 ;  Q8P1M4, GYRB_STRP8 ;
DR   P0A4L9, GYRB_STRPN ;  P0DG05, GYRB_STRPQ ;  P0A4M0, GYRB_STRR6 ;
DR   P77966, GYRB_SYNY3 ;  P77993, GYRB_THEMA ;  O87545, GYRB_TREDE ;
DR   O08399, GYRB_TREPA ;  Q9KVX3, GYRB_VIBCH ;  O51859, GYRB_VIBPA ;
DR   Q9YCB6, RGYR1_AERPE;  O67037, RGYR1_AQUAE;  Q97ZZ8, RGYR1_SULSO;
DR   Q971T7, RGYR1_SULTO;  Q9YC75, RGYR2_AERPE;  O67226, RGYR2_AQUAE;
DR   Q97ZF5, RGYR2_SULSO;  Q975P6, RGYR2_SULTO;  O29238, RGYR_ARCFU ;
DR   Q58907, RGYR_METJA ;  Q9UZ86, RGYR_PYRAB ;  Q8ZXT5, RGYR_PYRAE ;
DR   P95479, RGYR_PYRFU ;  O58530, RGYR_PYRHO ;  Q6F598, RGYR_PYRKO ;
DR   Q08582, RGYR_SULAC ;  P74759, RGYR_SULSH ;  O51934, RGYR_THEMA ;
DR   Q8R979, RGYR_THETN ;  O42130, TOP2A_CHICK;  P41515, TOP2A_CRIGR;
DR   P11388, TOP2A_HUMAN;  Q01320, TOP2A_MOUSE;  O46374, TOP2A_PIG  ;
DR   P41516, TOP2A_RAT  ;  O42131, TOP2B_CHICK;  Q64399, TOP2B_CRILO;
DR   Q02880, TOP2B_HUMAN;  Q64511, TOP2B_MOUSE;  P34534, TOP2M_CAEEL;
DR   P90520, TOP2M_DICDI;  P30182, TOP2_ARATH ;  Q00942, TOP2_ASFB7 ;
DR   P0C9C2, TOP2_ASFK5 ;  P34203, TOP2_ASFM2 ;  P0C9C0, TOP2_ASFP4 ;
DR   P0C9C1, TOP2_ASFWA ;  O16140, TOP2_BOMMO ;  Q23670, TOP2_CAEEL ;
DR   P87078, TOP2_CANAX ;  O93794, TOP2_CANGA ;  P27570, TOP2_CRIFA ;
DR   Q55BP5, TOP2_DICDI ;  P15348, TOP2_DROME ;  Q196X4, TOP2_IIV3  ;
DR   Q9QSK1, TOP2_IIV6  ;  O61078, TOP2_LEICH ;  Q5UQE6, TOP2_MIMIV ;
DR   O24308, TOP2_PEA   ;  Q9Y8G8, TOP2_PENCH ;  Q01879, TOP2_PICGU ;
DR   P41001, TOP2_PLAFK ;  P08096, TOP2_SCHPO ;  P12531, TOP2_TRYBB ;
DR   P30190, TOP2_TRYCR ;  P06786, TOP2_YEAST ;  P07065, TOP5_BPT4  ;
DR   Q9YE67, TOP6A_AERPE;  O29322, TOP6A_ARCFU;  Q5V4R4, TOP6A_HALMA;
DR   B0R4D2, TOP6A_HALS3;  Q9HR32, TOP6A_HALSA;  A2BLE8, TOP6A_HYPBU;
DR   Q8TQF8, TOP6A_METAC;  Q468I6, TOP6A_METBF;  Q57815, TOP6A_METJA;
DR   Q8PUB7, TOP6A_METMA;  O27089, TOP6A_METTH;  Q3IPW7, TOP6A_NATPD;
DR   Q9V134, TOP6A_PYRAB;  Q8U0K9, TOP6A_PYRFU;  O59209, TOP6A_PYRHO;
DR   Q5JH82, TOP6A_PYRKO;  O05208, TOP6A_SULSH;  Q971T1, TOP6A_SULTO;
DR   Q9YE64, TOP6B_AERPE;  Q9C5V6, TOP6B_ARATH;  O29605, TOP6B_ARCFU;
DR   Q5V4R5, TOP6B_HALMA;  B0R4D3, TOP6B_HALS3;  Q9HR31, TOP6B_HALSA;
DR   Q8TQF7, TOP6B_METAC;  Q468I5, TOP6B_METBF;  Q12WQ0, TOP6B_METBU;
DR   Q58434, TOP6B_METJA;  Q8PUB8, TOP6B_METMA;  A4YHK7, TOP6B_METS5;
DR   O27088, TOP6B_METTH;  Q3IPW6, TOP6B_NATPD;  Q9V135, TOP6B_PYRAB;
DR   Q8ZVM0, TOP6B_PYRAE;  Q8U0K8, TOP6B_PYRFU;  O74020, TOP6B_PYRHO;
DR   Q5JH81, TOP6B_PYRKO;  C3N5B3, TOP6B_SULIA;  C4KGX9, TOP6B_SULIK;
DR   C3MPN7, TOP6B_SULIL;  C3MYN1, TOP6B_SULIM;  C3NHT6, TOP6B_SULIN;
DR   C3NDW7, TOP6B_SULIY;  O05207, TOP6B_SULSH;  Q97ZF0, TOP6B_SULSO;
DR   Q971T2, TOP6B_SULTO;  C5A6R5, TOP6B_THEGJ;  B6YVS9, TOP6B_THEON;
DR   C6A3G4, TOP6B_THESM;  P09176, TOPL_BPT4  ;  P23992, TOPS_BPT4  ;
//