ENZYME entry: EC 6.1.1.10

Accepted Name
Methionine--tRNA ligase.
Alternative Name(s)
Methionine translase.
Methionyl-transfer ribonucleate synthetase.
Methionyl-transfer ribonucleic acid synthetase.
Methionyl-transfer RNA synthetase.
Methionyl-tRNA synthetase.
MetRS.
Reaction catalysed
ATP + L-methionine + tRNA(Met) <=> AMP + diphosphate + L-methionyl-tRNA(Met)
Comment(s)
In those organisms producing N-formylmethionyl-tRNA(fMet) for translation initiation, this enzyme also recognizes the initiator tRNA(fMet) and catalyzes the formation of L-methionyl-tRNA(fMet), the substrate for EC 2.1.2.9.
Cross-references
PROSITEPDOC00161
BRENDA6.1.1.10
EC2PDB6.1.1.10
ExplorEnz6.1.1.10
PRIAM enzyme-specific profiles6.1.1.10
KEGG Ligand Database for Enzyme Nomenclature6.1.1.10
IUBMB Enzyme Nomenclature6.1.1.10
IntEnz6.1.1.10
MEDLINEFind literature relating to 6.1.1.10
MetaCyc6.1.1.10
UniProtKB/Swiss-Prot
A8ZQ66, SYM1_ACAM1;  A8MG12, SYM1_ALKOO;  A0RKM3, SYM1_BACAH;  
Q81W03, SYM1_BACAN;  Q72Y44, SYM1_BACC1;  Q81JA8, SYM1_BACCR;  
Q6HBM0, SYM1_BACHK;  A9FBU8, SYM1_SORC5;  Q81XF9, SYM2_BACAN;  
Q815U6, SYM2_BACCR;  Q2T9L8, SYMC_BOVIN;  Q20970, SYMC_CAEEL;  
Q54X95, SYMC_DICDI;  Q8SQW5, SYMC_ENCCU;  P56192, SYMC_HUMAN;  
Q68FL6, SYMC_MOUSE;  C4V943, SYMC_NOSCE;  Q9UUF2, SYMC_SCHPO;  
Q6PF21, SYMC_XENLA;  P00958, SYMC_YEAST;  A6H7E1, SYMM_BOVIN;  
O74634, SYMM_CANAX;  Q54MZ8, SYMM_DICDI;  Q9VFL5, SYMM_DROME;  
Q96GW9, SYMM_HUMAN;  Q499X9, SYMM_MOUSE;  Q9C2H9, SYMM_NEUCR;  
O14000, SYMM_SCHPO;  Q90YI3, SYMM_TAKRU;  Q7T0Z0, SYMM_XENLA;  
P22438, SYMM_YEAST;  A1TTU1, SYM_ACIAC;  Q6FE36, SYM_ACIAD;  
B9MEX0, SYM_ACIET;  B7J7Y5, SYM_ACIF2;  B5ENA8, SYM_ACIF5;  
A1WBH1, SYM_ACISJ;  A3MZ70, SYM_ACTP2;  B3H0J7, SYM_ACTP7;  
B0BTA2, SYM_ACTPJ;  A6VQD5, SYM_ACTSZ;  A0KKF6, SYM_AERHH;  
Q9YCY3, SYM_AERPE;  Q8UFA2, SYM_AGRT5;  Q0VP51, SYM_ALCBS;  
B6EIY5, SYM_ALISL;  Q0AAG6, SYM_ALKEH;  O67298, SYM_AQUAE;  
Q9SVN5, SYM_ARATH;  O28819, SYM_ARCFU;  Q5P239, SYM_AROAE;  
A1KAG3, SYM_AZOSB;  C1DEF4, SYM_AZOVD;  C3P025, SYM_BACAA;  
C3LD96, SYM_BACAC;  B7JEJ3, SYM_BACC0;  B7INU9, SYM_BACC2;  
C1EYD5, SYM_BACC3;  B7HD62, SYM_BACC4;  B7HVW2, SYM_BACC7;  
B9J4E0, SYM_BACCQ;  Q5L7I8, SYM_BACFN;  Q64MP7, SYM_BACFR;  
Q9KGK8, SYM_BACHD;  P37465, SYM_BACSU;  Q8A3M1, SYM_BACTN;  
A6KYR3, SYM_BACV8;  A9VP41, SYM_BACWK;  Q1LT75, SYM_BAUCH;  
Q6MMA3, SYM_BDEBA;  C5C046, SYM_BEUC1;  B8DT48, SYM_BIFA0;  
A1A3N3, SYM_BIFAA;  P59076, SYM_BIFLO;  B7GP85, SYM_BIFLS;  
Q7VRX4, SYM_BLOFL;  Q492J8, SYM_BLOPB;  Q2KYS4, SYM_BORA1;  
Q0SMS1, SYM_BORAP;  Q7WP45, SYM_BORBR;  Q44951, SYM_BORBU;  
B7J2F0, SYM_BORBZ;  B5RME0, SYM_BORDL;  Q660T5, SYM_BORGA;  
B2S0T6, SYM_BORHD;  Q7W1D8, SYM_BORPA;  Q7W0F7, SYM_BORPE;  
B5RPT6, SYM_BORRA;  A1R019, SYM_BORT9;  Q8YH17, SYM_BRUME;  
P59078, SYM_BRUSU;  B8D8R1, SYM_BUCA5;  P57210, SYM_BUCAI;  
Q9ZHD7, SYM_BUCAP;  B8D715, SYM_BUCAT;  Q89AX4, SYM_BUCBP;  
B1YUT2, SYM_BURA4;  Q1BUH6, SYM_BURCA;  B1JWS3, SYM_BURCC;  
A0K9L0, SYM_BURCH;  B4E8E0, SYM_BURCJ;  Q0BCT3, SYM_BURCM;  
Q39DV4, SYM_BURL3;  A9AHJ8, SYM_BURM1;  A3MLM5, SYM_BURM7;  
A2SAF7, SYM_BURM9;  Q62LE0, SYM_BURMA;  A1V5W0, SYM_BURMS;  
A3NSL6, SYM_BURP0;  Q3JUY1, SYM_BURP1;  A3N6Y1, SYM_BURP6;  
Q63W90, SYM_BURPS;  Q2T087, SYM_BURTA;  A4JGW6, SYM_BURVG;  
Q143I7, SYM_BURXL;  A8MA54, SYM_CALMQ;  Q8RDD1, SYM_CALS4;  
Q9PP85, SYM_CAMJE;  B8H5U4, SYM_CAUCN;  Q9A884, SYM_CAUCR;  
B0T3J0, SYM_CAUSK;  A9WKM1, SYM_CHLAA;  Q5L5M3, SYM_CHLAB;  
B8G6F7, SYM_CHLAD;  Q3AQR4, SYM_CHLCH;  Q822N0, SYM_CHLCV;  
Q255A6, SYM_CHLFF;  B3ECI3, SYM_CHLL2;  Q9PL07, SYM_CHLMU;  
A1BF81, SYM_CHLPD;  Q9Z959, SYM_CHLPN;  B9LDY3, SYM_CHLSY;  
B0B9D9, SYM_CHLT2;  B3QT85, SYM_CHLT3;  Q3KMZ0, SYM_CHLTA;  
B0BB18, SYM_CHLTB;  P59077, SYM_CHLTE;  O84035, SYM_CHLTR;  
Q1QVN7, SYM_CHRSD;  Q7NYR7, SYM_CHRVO;  A8AEB2, SYM_CITK8;  
Q97EW5, SYM_CLOAB;  Q8XHG1, SYM_CLOPE;  Q899D9, SYM_CLOTE;  
Q480H5, SYM_COLP3;  Q6NIA5, SYM_CORDI;  Q8FR00, SYM_COREF;  
A4QCN5, SYM_CORGB;  Q8NRZ4, SYM_CORGL;  Q4JU18, SYM_CORJK;  
C4LHI6, SYM_CORK4;  B1VFI1, SYM_CORU7;  B6J4V8, SYM_COXB1;  
B6J3N7, SYM_COXB2;  A9KDF8, SYM_COXBN;  A9NA60, SYM_COXBR;  
Q83B24, SYM_COXBU;  A7MHL3, SYM_CROS8;  Q0K7K0, SYM_CUPNH;  
Q474X7, SYM_CUPPJ;  B3R678, SYM_CUPTR;  Q11RM3, SYM_CYTH3;  
Q47IK0, SYM_DECAR;  Q3Z9G6, SYM_DEHM1;  A5FS74, SYM_DEHMB;  
Q3ZZB2, SYM_DEHMC;  Q9RUF3, SYM_DEIRA;  A5EY62, SYM_DICNV;  
A8LIJ9, SYM_DINSH;  A7ZNT3, SYM_ECO24;  B7UFD1, SYM_ECO27;  
B7MEG9, SYM_ECO45;  B7L9Y6, SYM_ECO55;  Q8X7E7, SYM_ECO57;  
B5YV64, SYM_ECO5E;  B7NPL8, SYM_ECO7I;  B7MX36, SYM_ECO81;  
B7M4V9, SYM_ECO8A;  C4ZSJ8, SYM_ECOBW;  B1X7K4, SYM_ECODH;  
A8A1X8, SYM_ECOHS;  A1ACX8, SYM_ECOK1;  Q0TFX8, SYM_ECOL5;  
Q8FFX8, SYM_ECOL6;  B1IYW7, SYM_ECOLC;  P00959, SYM_ECOLI;  
B7NCE4, SYM_ECOLU;  B6HYV5, SYM_ECOSE;  B1LN54, SYM_ECOSM;  
Q1R9V8, SYM_ECOUT;  A4WCF6, SYM_ENT38;  Q837B3, SYM_ENTFA;  
B2VIF6, SYM_ERWT9;  B7LV75, SYM_ESCF3;  A5FLM7, SYM_FLAJ1;  
A6GVQ2, SYM_FLAPJ;  Q14GV0, SYM_FRAT1;  A7NAE2, SYM_FRATF;  
Q2A4Y6, SYM_FRATH;  A0Q556, SYM_FRATN;  Q0BNA8, SYM_FRATO;  
Q5NFE7, SYM_FRATT;  A4IXI6, SYM_FRATW;  Q8RE57, SYM_FUSNN;  
P23920, SYM_GEOSE;  A0M5Z9, SYM_GRAFK;  Q7VMC9, SYM_HAEDU;  
Q4QJZ5, SYM_HAEI8;  A5UBS8, SYM_HAEIE;  A5UF42, SYM_HAEIG;  
P43828, SYM_HAEIN;  B8F3E3, SYM_HAEPS;  Q2SKU2, SYM_HAHCH;  
A1WUY7, SYM_HALHL;  Q5V1B3, SYM_HALMA;  B8D274, SYM_HALOH;  
Q9HSA4, SYM_HALSA;  Q18JV4, SYM_HALWD;  C4K759, SYM_HAMD5;  
Q9ZKG9, SYM_HELPJ;  P56127, SYM_HELPY;  A4G3S6, SYM_HERAR;  
Q0I3W7, SYM_HISS1;  B0UV72, SYM_HISS2;  A2BLU2, SYM_HYPBU;  
Q0C161, SYM_HYPNA;  Q5R0G6, SYM_IDILO;  A8ABN0, SYM_IGNH4;  
A6SX05, SYM_JANMA;  Q28MK0, SYM_JANSC;  A6W6U1, SYM_KINRD;  
B5XP89, SYM_KLEP3;  A6TBK7, SYM_KLEP7;  B1L7J9, SYM_KORCO;  
Q9CHE0, SYM_LACLA;  Q88Z97, SYM_LACPL;  Q5X105, SYM_LEGPA;  
A5II55, SYM_LEGPC;  Q5ZRJ9, SYM_LEGPH;  Q5WST1, SYM_LEGPL;  
B0SHA8, SYM_LEPBA;  Q04Q66, SYM_LEPBJ;  Q054R6, SYM_LEPBL;  
B0SQX5, SYM_LEPBP;  B1XWM2, SYM_LEPCP;  Q72MR4, SYM_LEPIC;  
Q8EZD6, SYM_LEPIN;  Q92F90, SYM_LISIN;  Q724N6, SYM_LISMF;  
Q8YAF2, SYM_LISMO;  A0L8S1, SYM_MAGSM;  Q65S22, SYM_MANSM;  
A1TZ66, SYM_MARHV;  Q0ANL8, SYM_MARMM;  A6UUN1, SYM_META3;  
Q8TIU5, SYM_METAC;  A7I6H7, SYM_METB6;  Q46F18, SYM_METBF;  
Q12UQ9, SYM_METBU;  Q60CR0, SYM_METCA;  Q1H2F4, SYM_METFK;  
Q2FU77, SYM_METHJ;  Q58659, SYM_METJA;  Q8TX28, SYM_METKA;  
A2SRE2, SYM_METLZ;  A4FZL1, SYM_METM5;  A6VIW5, SYM_METM7;  
Q8PYJ4, SYM_METMA;  A3CX39, SYM_METMJ;  Q6M0E5, SYM_METMP;  
B8GFL4, SYM_METPE;  A2SEY3, SYM_METPP;  A5UJ98, SYM_METS3;  
A4YI01, SYM_METS5;  Q2NI31, SYM_METST;  O26687, SYM_METTH;  
A0B7K2, SYM_METTP;  A6URW2, SYM_METVS;  Q5UR82, SYM_MIMIV;  
P59952, SYM_MYCBO;  P47267, SYM_MYCGE;  Q9CD55, SYM_MYCLE;  
P75091, SYM_MYCPN;  Q50319, SYM_MYCPU;  P9WFU4, SYM_MYCTO;  
P9WFU5, SYM_MYCTU;  Q1D8K2, SYM_MYXXD;  Q74MZ1, SYM_NANEQ;  
Q3IT47, SYM_NATPD;  Q5F585, SYM_NEIG1;  A9LZS9, SYM_NEIM0;  
Q9JWP0, SYM_NEIMA;  Q9K1Q0, SYM_NEIMB;  A1KR57, SYM_NEIMF;  
Q0AES9, SYM_NITEC;  Q82WP0, SYM_NITEU;  Q2Y7P0, SYM_NITMU;  
Q3JCG5, SYM_NITOC;  A1SGG5, SYM_NOCSJ;  Q8Z068, SYM_NOSS1;  
P59079, SYM_OCEIH;  Q9ZTS1, SYM_ORYSJ;  A6LFP0, SYM_PARD8;  
A1B3P3, SYM_PARDP;  Q6MDG0, SYM_PARUW;  P57838, SYM_PASMU;  
Q6D7B6, SYM_PECAS;  C6DCI4, SYM_PECCP;  Q3B3N3, SYM_PELLD;  
B4SGQ6, SYM_PELPB;  Q7N6J6, SYM_PHOLL;  Q6LSZ7, SYM_PHOPR;  
Q6L1M5, SYM_PICTO;  A1VKF9, SYM_POLNA;  Q12F12, SYM_POLSJ;  
B2RHF5, SYM_PORG3;  Q7MXK7, SYM_PORGI;  Q6A707, SYM_PROAC;  
B4ESY6, SYM_PROMH;  A4SE77, SYM_PROVI;  Q48LT7, SYM_PSE14;  
Q15UM1, SYM_PSEA6;  A6V1U3, SYM_PSEA7;  B7UWJ8, SYM_PSEA8;  
Q02QX1, SYM_PSEAB;  Q9HYC7, SYM_PSEAE;  Q1IDZ3, SYM_PSEE4;  
Q4K758, SYM_PSEF5;  C3KBZ7, SYM_PSEFS;  Q3IL10, SYM_PSEHT;  
A4XS54, SYM_PSEMY;  A5VZI8, SYM_PSEP1;  Q3K7L0, SYM_PSEPF;  
B0KUD8, SYM_PSEPG;  Q88NV7, SYM_PSEPK;  B1J1D1, SYM_PSEPW;  
Q87XN0, SYM_PSESM;  Q4ZPK6, SYM_PSEU2;  A4VJ05, SYM_PSEU5;  
Q4FRS8, SYM_PSYA2;  Q1QAD0, SYM_PSYCK;  A1SVA5, SYM_PSYIN;  
A5WG58, SYM_PSYWF;  Q9V011, SYM_PYRAB;  Q8ZU56, SYM_PYRAE;  
A4WKG3, SYM_PYRAR;  A3MVB7, SYM_PYRCJ;  Q8U221, SYM_PYRFU;  
O58721, SYM_PYRHO;  A1RRE2, SYM_PYRIL;  B1YAZ7, SYM_PYRNV;  
Q1LJN4, SYM_RALME;  Q8XWT9, SYM_RALSO;  Q98MV8, SYM_RHILO;  
Q92PX0, SYM_RHIME;  Q7URP3, SYM_RHOBA;  Q21TB9, SYM_RHOFT;  
A3PLG8, SYM_RHOS1;  Q3J0T3, SYM_RHOS4;  A4WV24, SYM_RHOS5;  
B9KKH3, SYM_RHOSK;  Q1RJZ5, SYM_RICBR;  Q92GS6, SYM_RICCN;  
Q4UMX2, SYM_RICFE;  Q9ZCP0, SYM_RICPR;  Q68W54, SYM_RICTY;  
A7NND5, SYM_ROSCS;  Q166L9, SYM_ROSDO;  A5UUW9, SYM_ROSS1;  
Q1AST1, SYM_RUBXD;  Q5LTL1, SYM_RUEPO;  Q1GEI7, SYM_RUEST;  
A1AWL4, SYM_RUTMC;  Q21I21, SYM_SACD2;  A4F7W6, SYM_SACEN;  
B5EXZ5, SYM_SALA4;  A8M218, SYM_SALAI;  A9MKV0, SYM_SALAR;  
Q57MI5, SYM_SALCH;  B5FMX1, SYM_SALDC;  B5R0E7, SYM_SALEP;  
B5RBZ5, SYM_SALG2;  B4T9X0, SYM_SALHS;  B4SXY7, SYM_SALNS;  
Q5PJ43, SYM_SALPA;  A9N7I2, SYM_SALPB;  C0Q0Y1, SYM_SALPC;  
B5BE81, SYM_SALPK;  Q2S2A3, SYM_SALRD;  B4TNL2, SYM_SALSV;  
Q8Z5C3, SYM_SALTI;  A4X307, SYM_SALTO;  Q8ZNN4, SYM_SALTY;  
A8GC37, SYM_SERP5;  A1S798, SYM_SHEAM;  B8E958, SYM_SHEB2;  
A3D5E5, SYM_SHEB5;  A6WP56, SYM_SHEB8;  A9L4F6, SYM_SHEB9;  
Q12MI8, SYM_SHEDO;  Q081H3, SYM_SHEFN;  B0TJ05, SYM_SHEHH;  
A3QD92, SYM_SHELP;  Q8EDX2, SYM_SHEON;  A8H3V2, SYM_SHEPA;  
A4Y7K8, SYM_SHEPC;  A0KW24, SYM_SHESA;  A8FWN7, SYM_SHESH;  
Q0HJN6, SYM_SHESM;  Q0HVY2, SYM_SHESR;  A1RIY0, SYM_SHESW;  
B1KQM2, SYM_SHEWM;  B2TVX7, SYM_SHIB3;  Q323B4, SYM_SHIBS;  
Q32EI8, SYM_SHIDS;  Q0T324, SYM_SHIF8;  Q83KH0, SYM_SHIFL;  
Q3Z096, SYM_SHISS;  Q2NUD0, SYM_SODGM;  Q5HII6, SYM_STAAC;  
P67578, SYM_STAAM;  P67579, SYM_STAAN;  Q6GJI1, SYM_STAAR;  
Q6GBZ8, SYM_STAAS;  Q8NY00, SYM_STAAW;  Q5HRR5, SYM_STAEQ;  
Q8CQU3, SYM_STAES;  Q4L3E7, SYM_STAHJ;  Q49UZ9, SYM_STAS1;  
Q82F60, SYM_STRAW;  Q9F2I9, SYM_STRCO;  B4SRG1, SYM_STRM5;  
B2FPT0, SYM_STRMK;  Q9A178, SYM_STRP1;  P0DG48, SYM_STRP3;  
Q5XDK8, SYM_STRP6;  C1C727, SYM_STRP7;  Q8P298, SYM_STRP8;  
P67580, SYM_STRPN;  P0DG49, SYM_STRPQ;  B2IQ55, SYM_STRPS;  
P67581, SYM_STRR6;  Q4J8M3, SYM_SULAC;  C3MW97, SYM_SULIM;  
Q9UWW2, SYM_SULSO;  Q971C1, SYM_SULTO;  Q55729, SYM_SYNY3;  
Q9HJ12, SYM_THEAC;  P59081, SYM_THEEB;  Q47SZ0, SYM_THEFY;  
Q5JDZ7, SYM_THEKO;  O33925, SYM_THEMA;  B6YUN0, SYM_THEON;  
A1RXT9, SYM_THEPD;  B9KZR0, SYM_THERP;  P23395, SYM_THET8;  
Q979B7, SYM_THEVO;  Q31GU1, SYM_THICR;  Q3SKG8, SYM_THIDA;  
C4LEX5, SYM_TOLAT;  Q73NT9, SYM_TREDE;  O83776, SYM_TREPA;  
Q0W0H2, SYM_UNCMA;  Q9PQU6, SYM_UREPA;  A1WRC4, SYM_VEREI;  
A5CWL9, SYM_VESOH;  A5F2P8, SYM_VIBC3;  A7MZT3, SYM_VIBCB;  
Q9KT69, SYM_VIBCH;  Q5E3Z7, SYM_VIBF1;  B5FG53, SYM_VIBFM;  
Q87N07, SYM_VIBPA;  B7VLW8, SYM_VIBTL;  Q8D8F2, SYM_VIBVU;  
Q7MM14, SYM_VIBVY;  Q8D219, SYM_WIGBR;  Q8PMP0, SYM_XANAC;  
Q3BVP1, SYM_XANC5;  Q4USM5, SYM_XANC8;  B0RWA1, SYM_XANCB;  
Q8PAY7, SYM_XANCP;  Q2P4E9, SYM_XANOM;  B2SRQ4, SYM_XANOP;  
Q5H1J3, SYM_XANOR;  B2I7S0, SYM_XYLF2;  Q9PFV8, SYM_XYLFA;  
B0U472, SYM_XYLFM;  Q87B68, SYM_XYLFT;  A1JTX6, SYM_YERE8;  
A7FJJ6, SYM_YERP3;  Q1C9T8, SYM_YERPA;  B2JZK3, SYM_YERPB;  
Q8ZG01, SYM_YERPE;  A9R2M7, SYM_YERPG;  Q1CGU4, SYM_YERPN;  
A4TKM9, SYM_YERPP;  Q66C72, SYM_YERPS;  B1JPY8, SYM_YERPY;  

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