ENZYME entry: EC 6.1.1.23

Accepted Name
Aspartate--tRNA(Asn) ligase.
Alternative Name(s)
Nondiscriminating aspartyl-tRNA synthetase.
Reaction catalysed
ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + aspartyl-tRNA(Asx)
Comment(s)
  • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
  • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
  • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
  • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
  • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
Cross-references
BRENDA6.1.1.23
EC2PDB6.1.1.23
ExplorEnz6.1.1.23
PRIAM enzyme-specific profiles6.1.1.23
KEGG Ligand Database for Enzyme Nomenclature6.1.1.23
IUBMB Enzyme Nomenclature6.1.1.23
IntEnz6.1.1.23
MEDLINEFind literature relating to 6.1.1.23
MetaCyc6.1.1.23

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