ENZYME entry: EC

Accepted Name
Aspartate--tRNA(Asn) ligase.
Alternative Name(s)
Nondiscriminating aspartyl-tRNA synthetase.
Reaction catalysed
ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)
  • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC
  • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
  • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
  • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
  • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC into asparaginyl-tRNA(Asn).
PRIAM enzyme-specific profiles6.1.1.23
KEGG Ligand Database for Enzyme Nomenclature6.1.1.23
IUBMB Enzyme Nomenclature6.1.1.23
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-