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ENZYME entry: EC 18.104.22.168
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|Nondiscriminating glutamyl-tRNA synthetase.|
|ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)|
- When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as
- It has, however, diminished discrimination, so that it can also form
- This relaxation of specificity has been found to result from the
absence of a loop in the tRNA that specifically recognizes the third
position of the anticodon.
- This accounts for the ability of this enzyme in, for example,
Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and
tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
- The ability of this enzyme to recognize both tRNA(Glu) and one of the
tRNA(Gln) isoacceptors derives from their sharing a major identity
element, a hypermodified derivative of U34 (5-methylaminomethyl-2-
- The glutamyl-tRNA(Gln) is not used in protein synthesis until it is
converted by EC 22.214.171.124 into glutaminyl-tRNA(Gln).
|PRIAM enzyme-specific profiles||126.96.36.199|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.52|
|IUBMB Enzyme Nomenclature||184.108.40.206|
|MEDLINE||Find literature relating to 220.127.116.11|
entries corresponding to 6.1.1.-
entries corresponding to 6.1.-.-
entries corresponding to 6.-.-.-